PROTECTIVE AND THERAPEUTIC EFFECTS OF OLIVE OIL AND FICUS CARICA AS NATURAL ANTIOXIDANTS ON SOME BIOCHEMICAL PARAMETERS IN LIVER OF Γ-Irradiated MALE ALBINO RATS

Antioxidant and Hepatoprotective Effects of Fig Fruit Extract with Olive Oil and Date-Palm Fruit Extract on Hepatic Toxicity of Oral Subchronic Exposure to Some Nanoparticles in Wistar Rats

“…Te oxidative damage to cells caused an alteration in both lipid bilayer fuidity and permeability properties [35]. In agreement with the present results, there was a directly proportional relationship between TBARS and the oxidative stress that caused biochemical alterations in diferent parameters [36,37]. Te increased TBARS after SiO 2 NPs, Al 2 O 3 NPs, or ZnONPs administration could be attributed to the produced ROS that interacts with the phospholipids portion of the cell membrane and initiates the lipid peroxidation chain reaction [23,32].…”

The beneficial effect of natural antioxidants from olive oil with fig and date palm fruit extracts on biochemical and hematological parameters in rats treated with doxorubicin and γ-radiation

“…OFD is rich in polyphenolic substances, which have received widespread attention because of their potential for preventing some common chronic diseases. Polyphenols are reported to have antiinflammatory, antioxidant, antidiabetic, and hepatoprotective effects (Bashandy et al 2014;El Arem et al 2014).…”

“…This was demonstrated by significantly ameliorated oxidative stress markers (TBARS, GSH, and NO) in the liver tissue compared with the DOX-treated and (or) R-treated rats. This might be a result of the protective action of OFD active ingredients modifying membrane organization and their ability to scavenge oxidation-initiating agents (Bashandy et al 2014;Fathy et al 2018). The antioxidant effect of OFD is mainly due to phenolic compounds, which are able to donate a hydrogen atom to the free radicals, thus stopping the chain reaction propagation during the lipid peroxidation process (Sanchez-Mareno et al 1998).…”

“…The chronic administration of plant extracts might augment the major cellular endogenous antioxidants, and is identified as a promising approach to combat oxidative stress (Bashandy et al 2014;Fathy et al 2017b). The major benefit of the Mediterranean diet is its high level of antioxidants derived from fruits and vegetables, including olive oil, figs, and date palm fruits, which contribute antioxidant vitamins, minerals, flavonoids, and polyphenol content (Solomon et al 2006).…”

“…The major benefit of the Mediterranean diet is its high level of antioxidants derived from fruits and vegetables, including olive oil, figs, and date palm fruits, which contribute antioxidant vitamins, minerals, flavonoids, and polyphenol content (Solomon et al 2006). In addition, mixed plant extracts showed a higher diversity of polyphenols resulting in greater stability and bioaccessibility of antioxidants compared with a single fruit extract (Bashandy et al 2014;Kamiloglu et al 2014;Fathy et al 2018).…”