Protective and Therapeutic Effects of Licorice in Rats With Acute Tubular Necrosis

Aksoy, Nurten; Doğan, Yunus; İriadam, Mehmet; Bıtıren, Muharrem; Uzer, Elmas; Ozgonul, Abdullah; Aksoy, Şahin

doi:10.1053/j.jrn.2011.07.002

Cited by 18 publications

(9 citation statements)

References 28 publications

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Section: Discussionmentioning

confidence: 99%

“…Acute kidney damage is often treated using G. glabra , which stimulates increased aldosterone and cortisone production from the adrenal cortex—hormones, which alleviate stress and exhaustion (Aksoy et al., 2012). Glycyrrhiza glabra has long been used in traditional medical contexts, especially Chinese medicine, in the treatment of kidney‐related disorders (Aksoy et al., 2012), and its nephroprotective effects are well‐established. Studies have identified G. glabra 's protective effect to be related to its antioxidant properties (Ju et al., 2017), which is in line with this study's finding of GPX and SOD restoration following G. glabra administration.…”

Section: Discussionmentioning

confidence: 99%

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Ameliorative impacts of Glycyrrhiza glabra root extract against nephrotoxicity induced by gentamicin in mice

Nassan

Soliman

Aldhahrani

et al. 2021

Food Science & Nutrition

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Gentamicin is an effective antibiotic that has been used worldwide for many years. While considered an essential medicine by the WHO, gentamicin can also lead to severe kidney damage. This study explored the ameliorative effects of Glycyrrhiza glabra root extract on gentamicin‐induced renal injury in mice. Four groups of n = 7 mice were used: (a) control; (b) G. glabra‐only; (c) gentamicin‐only; and (d) gentamicin plus G. glabra. Kidney samples were tested for: antioxidant enzyme activity (superoxide dismutase [SOD] and glutathione peroxidase [Gpx]); expression of HO‐1 and nuclear factor erythroid 2‐related factor 2 genes; expression of Cox‐2 and Bax; cytokine levels (IL‐1β, and IL‐6); histopathological anomalies; and standard renal functional component levels (creatinine, urea, and blood urea nitrogen). The effects of gentamicin were generally reversed or normalized following treatment with G. glabra root extract. Gentamicin decreased Gpx and SOD parameters and increased IL‐1 β and IL‐6 levels, but these returned to normal in the G. glabra‐treated group. Gentamicin upregulated tissue levels of Cox‐2 and Bax, and downregulated HO‐1 and Nrf‐2 expression but again, and these levels returned to normal in the group treated with G. glabra. Mice that had received gentamicin exhibited acute renal blood vessel congestion, focal interstitial round cell aggregation, and hydropic degeneration of renal tubular epithelium. However, those that had also received G. glabra showed a normal histopathology. Findings from this study indicate that in mouse models, gentamicin‐induced kidney damage can be reversed or ameliorated by administering G. glabra, so it can be considered as an effective complimentary therapy.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Ameliorative impacts of Glycyrrhiza glabra root extract against nephrotoxicity induced by gentamicin in mice

Nassan

Soliman

Aldhahrani

et al. 2021

Food Science & Nutrition

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“…San Ren Tang (three-kernels decoction) is composed of eight compounds (Table 1), which are used to promote urination and may have anti-inflammatory effects. [44][45][46][47][48] Wei Ling Tang is composed of 11 compounds that are used to promote urination, [49][50][51] decrease nephrocalcinosis and crystal formation, 43 provide antioxidation [52][53][54][55][56] and are anti-inflammatory. [57][58][59] Neither of these herbal preparations induced a diuresis or decreased urinary saturation for calcium oxalate or struvite.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of three herbal compounds used for the management of lower urinary tract disease in healthy cats: a pilot study

Daniels¹,

Bartges

Raditic

et al. 2017

Journal of Feline Medicine and Surgery

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“…In general, four types of herbal medicine exist: Asian, European, Indigenous, and Neo-Western. The Asian and European systems go back thousands of years, appear in pharmacopoeia, and with such a tradition of use, are better understood than those of indigenous origins that are often only orally recorded [5]. Pharmacopoeia is an official book published usually under the jurisdiction of the government and which contains a list of drugs, their formulas, and methods of identification, requirements and tests for their strength and purity, and other related information.…”

Section: Introductionmentioning

confidence: 99%

Medicinal Plant Poisoning and Herb-Drug Interaction: A Review

Mistry¹,

Singh²,

Patel³

et al. 2021

JASR

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It is estimated that three quarters of the earth populace rely on herbal and conventional medicine as an origin for principal health care. Therefore, it is one of the most important and challenging errands for scientists working in drug research to examine the effectiveness of herbal medicine, to divide constructive from adverse effects, to recognize active ideology in medicinal plants and to ban poisonous plants or contaminations from herbal mixtures. In the present review, some problems are critically discussed. Botanical misidentification or mislabeling of plant material can play a role for toxic reactions in humans. Some plant descriptions in traditional herbal medicine (e.g. traditional Chinese medicine) have changed over time, which may lead to unintended intoxication by using incorrect plants. A difficulty is also the contamination of herbals with microorganisms, fungal toxins such as aflatoxin, with pesticides and heavy metals. Unprincipled processing, which differs from safe traditional preparation represents one more potential source for herbal poisoning. Unwanted effects of herbal products may also expand by the interaction of herbs with conventional drugs upon associated intake. The art of herbal medicine is to divide pharmacologically and therapeutically prec ious herbal drugs from harmful and toxic ones and to expand combinations of medicinal plants as safe and efficient herbal remedies. Standardization and strict control measures are essential to monitor sustainable high quality of herbal products and to exclude contaminations that badly affect patients consuming herbal medicine.

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Protective and Therapeutic Effects of Licorice in Rats With Acute Tubular Necrosis

Abstract: Licorice ameliorates GM-induced nephrotoxicity and oxidative damage by scavenging oxygen free radicals, decreasing LPO, and improving antioxidant defense.

Cited by 18 publications

References 28 publications

Ameliorative impacts of Glycyrrhiza glabra root extract against nephrotoxicity induced by gentamicin in mice

Ameliorative impacts of Glycyrrhiza glabra root extract against nephrotoxicity induced by gentamicin in mice

Evaluation of three herbal compounds used for the management of lower urinary tract disease in healthy cats: a pilot study

Medicinal Plant Poisoning and Herb-Drug Interaction: A Review

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