Protective effect and induction of DNA repair by Myrciaria cauliflora seed extract and pedunculagin on cyclophosphamide-induced genotoxicity

Abstract

Ellagitannins are well-known antioxidants in medicinal plants, foods, and edible fruits, particularly in Myrciaria cauliflora (jabuticaba). Thus, this study aimed to evaluate the protective effects of jabuticaba seed extract (JSE) and pedunculagin using in vivo micronucleus test and comet assay in mouse bone marrow cells, in combination with cyclophosphamide (CP), a bioreductive alkylating agent. The ellagitannin composition of JSE was determined by HPLC/PDA, with castalagin, vescalagin, and pedunculagin as the main compounds (124.4, 45.5, and 15.6mg/g dw, respectively). Results from pre- and co- treatments with JSE or pedunculagin clearly showed their protective action against CP-induced micronuclei and DNA damage. The effects of both tannins in post-treatments with CP suggested they influence DNA repair systems. These findings indicate that JSE and pedunculagin possess chemopreventive as well as DNA repair-inducing properties.

Tannins inhibit SARS‐CoV‐2 through binding with catalytic dyad residues of 3CL pro : An in silico approach with 19 structural different hydrolysable tannins

“…This molecule is not inhibitor of HERG l and HERG ll that means it is not harmful to cardiac muscles (heart muscles). Previously, pedunculagin, tercatain, and castalin which could be extracted from pomegranates, walnut, Indian gooseberry, oak wood, leaves of Melaleuca quinquenervia, Terminalia catappa , and Combretum glutinosum showed antiviral activity and other biological activities (Chang et al., 1995; Silva et al., 2016; Zuo, LI, Chen, & Xu, 2005). In a related study, Park et al.…”

“…Continued biological activities (Chang et al, 1995;Silva et al, 2016;Zuo, LI, Chen, & Xu, 2005). In a related study, Park et al 2017 Figure S1a).…”

Phytochemistry and medicinal properties of Psidium guajava L. leaves: A review

“…The Fig. 1 shows some of the important phytochemicals found in guava leaves [Phenolic (gallic acid (8)), Flavonoid (quercetin (9)), Ellagitannins (corilagin (10)), Tannin (pedunculagin (11)) and Terpenoid (β-caryophyllene (12)) respectively.…”

Antihypertensive Effects of Brazilian Fruits

“…In addition to these nutrients, fruits contain secondary metabolites such as phenolic acids, anthocyanins and flavonoids that have many beneficial effects on the body (Aune et al, 2017). Thus, by having these qualities, there is a potential for fruits to act as adjuvants in the treatment of various diseases (Dametto et al, 2017;dos Reis et al, 2018;Johnston, 2009;Silva et al, 2016;Vasudevan et al, 2009). Brazil has a large land area and a great diversity, which is favorable to the discovery of natural products with biological activity (Valli et al, 2018).…”