Protective Effect and Mechanism of Placenta Extract on Liver

Abstract

The placenta contains multiple biologically active substances, which exert antioxidation, anti-inflammatory, immunomodulatory, and delayed aging effects. Its extract can improve hepatic morphology and function: on the one hand, it can reduce liver interstitial collagen deposition, lipogenesis, and inflammatory cell infiltration and improve fibrosis; on the other hand, it can prevent hepatocellular degeneration by scavenging reactive oxygen species (ROS) and inhibiting inflammatory cytokine production, further improve hepatocyte apoptosis and necrosis, and promote hepatocyte regeneration, making it a promising liver-protective agent. Current research on placenta extract (PE) mainly focuses on treating a specific type of liver injury, and there are no systematic reports. Therefore, this review comprehensively summarizes the treatment reports of PE on liver injury and analyzes its mechanism of action.

The human neuroprotective placental protein composition suppressing tinnitus and restoring auditory brainstem response in a rodent model of sodium salicylate-induced ototoxicity

“…Human placenta extracts (HPEs) are obtained by lysing human placental tissues collected at full-term delivery. According to the data obtained from various research studies, HPEs possess anti-inflammatory, analgesic [ 50 ], antioxidant, antiapoptotic [ 51 , 52 ], cytoprotective and radioprotective [ 53 ], and anti-allergic properties and express hormonal activity [ 54 ], as well as stimulate proliferation and regenerative processes [ 55 ]. Based on such studies that showed the multi-potent features of HPEs, and the pathophysiology of tinnitus, as a complex medical condition with no standard treatment, we hypothesized that placenta extract might be able to reverse salicylate-induced changes.…”