Protective effect and mechanism of Schistosoma japonicum soluble egg antigen against type 1 diabetes in NOD mice

Wang, Lixia; Gao, Yan-ru; Pan, Qun; Tang, Chaoliang; Zhang, Ronghui; Li, Yanhong; Zheng, Chunlan

doi:10.1007/s13410-021-00970-4

Cited by 2 publications

(2 citation statements)

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“…In total, 29 studies compared baseline measures of diabetes or pancreatic inflammation in those with and without helminth infection. Seventeen studies (59%; 11 animal, 6 human) reported lower measures of diabetes or pancreatic inflammation [14,25,32,68,[72][73][74][75][76][77][78][79][80][81][82][83][84], 6 (21%; all human) demonstrated higher measures of these factors [6,[85][86][87][88][89], and 5 (17%; all human) showed no association with respect to helminth infections [53,58,59,71,90]. In the final study there was no difference in hemoglobin A1c or fasting glucose regardless of helminth infection or antiretroviral status among HIV-infected individuals, while among HIV-uninfected individuals, soil-transmitted helminth (STH) infection was inversely associated with hemoglobin A1c (5.2% vs. 5.5% in STH-uninfected controls) after adjustment for age and sex [69].…”

Section: Helminths and Diabetesmentioning

confidence: 99%

“…In comparison to the 6 human studies, 11 animal studies with mouse models using Schistosoma species (n = 7), Fasciola hepatica (n = 2), and filarial species (n = 2) also documented lower measures of diabetes or pancreatic inflammation among helminth-infected animals [72,[75][76][77][78][79][80][81][82][83][84]. Seven of 11 documented histopathological changes of the pancreas in mice and found that helminth infection was associated with less pancreatic inflammation, degradation, and other architectural changes in mice who were infected or exposed to helminth antigens as compared to uninfected mice [72,[76][77][78][79][80][81].…”

Section: Helminths and Diabetesmentioning

confidence: 99%

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Effects of helminths and anthelmintic treatment on cardiometabolic diseases and risk factors: A systematic review

et al. 2023

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Background Globally, helminth infections and cardiometabolic diseases often overlap in populations and individuals. Neither the causal relationship between helminth infections and cardiometabolic diseases nor the effect of helminth eradication on cardiometabolic risk have been reviewed systematically in a large number of human and animal studies. Methods We conducted a systematic review assessing the reported effects of helminth infections and anthelmintic treatment on the development and/or severity of cardiometabolic diseases and risk factors. The search was limited to the most prevalent human helminths worldwide. This study followed PRISMA guidelines and was registered prospectively in PROSPERO (CRD42021228610). Searches were performed on December 10, 2020 and rerun on March 2, 2022 using Ovid MEDLINE ALL (1946 to March 2, 2022), Web of Science, Cochrane Library, Global Index Medicus, and Ovid Embase (1974 to March 2, 2022). Randomized clinical trials, cohort, cross-sectional, case-control, and animal studies were included. Two reviewers performed screening independently. Results Eighty-four animal and human studies were included in the final analysis. Most studies reported on lipids (45), metabolic syndrome (38), and diabetes (30), with fewer on blood pressure (18), atherosclerotic cardiovascular disease (11), high-sensitivity C-reactive protein (hsCRP, 5), and non-atherosclerotic cardiovascular disease (4). Fifteen different helminth infections were represented. On average, helminth-infected participants had less dyslipidemia, metabolic syndrome, diabetes, and atherosclerotic cardiovascular disease. Eleven studies examined anthelmintic treatment, of which 9 (82%) reported post-treatment increases in dyslipidemia, metabolic syndrome, and diabetes or glucose levels. Results from animal and human studies were generally consistent. No consistent effects of helminth infections on blood pressure, hsCRP, or cardiac function were reported except some trends towards association of schistosome infection with lower blood pressure. The vast majority of evidence linking helminth infections to lower cardiometabolic diseases was reported in those with schistosome infections. Conclusions Helminth infections may offer protection against dyslipidemia, metabolic syndrome, diabetes, and atherosclerotic cardiovascular disease. This protection may lessen after anthelmintic treatment. Our findings highlight the need for mechanistic trials to determine the pathways linking helminth infections with cardiometabolic diseases. Such studies could have implications for helminth eradication campaigns and could generate new strategies to address the global challenge of cardiometabolic diseases.

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