Protective Effect of Acorus calamus LINN on Free Radical Scavengers and Lipid Peroxidation in Discrete Regions of Brain against Noise Stress Exposed Rat

Manikandan, S.; Srikumar, Ramakrishnan; Parthasarathy, Narayanaperumal Jeya; Devi, Rathinasamy Sheela

doi:10.1248/bpb.28.2327

Cited by 82 publications

(62 citation statements)

References 35 publications

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“…As reported earlier 51,15 , the LPO in the noise stress exposed animals in this study was also observed to increase significantly from the controls which was prevented by the administration of AC as well as α-asarone.…”

Section: Two Subsets Of T Helper Cells (Th Cells) Namelysupporting

confidence: 89%

“…The rhizome of Acorus calamus Linn. has been studied to possess cardioprotective 13 , anti ulcer effects 14 , antistress and antioxidant property 15 , antidiarrhoeal 16 , dyslipidemic 17 , 20 . It has been reported to prevent tonic clonic and partial seizures in mice 21 , to exert beneficial effect in tibial and sural nerve transection induced neuropathic pain in rats 22 and vascular relaxant effect 23 .…”

Section: Introductionmentioning

confidence: 99%

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Effect of Acorus Calamus Linn. And Its Active Principle on Noise Stress-Induced Changes on Immune System

Subramanian

2012

Int J of Biomed & Adv Res

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Noise is an inevitable everyday stressor in our lives and is detrimental to our immune system. The aim of the present study was to investigate the potential of ethyl acetate extract of Acorus Calamus (AC) and its active component, α-asarone on the noise stress induced changes on immune system of Wistar albino rats. Noise stress of 100dB for 4h/day for 30 days was employed in this study to observe the effect of stress on immune system and the dosage of AC and α-asarone used were 50 mg / Kg b.wt and 9mg/Kg b.wt respectively for 45 days. Sheep red blood cells (5 × 10 9 cells/ml) were used to immunize the animals. Six different groups were used: Control Immunized, AC treated immunized, α-asarone treated immunized, Noise stress immunized, AC treated stress immunized, α-asarone treated stress immunized groups. The immune status was assessed by the serum cytokine levels of IL-2, IL-4, IFN-γ and the CD4, CD8 T cell lymphocyte phenotype in spleen while biochemical markers of oxidative stress-LPO, GSH in spleen and corticosterone in plasma were estimated in the immune challenged animals. Results showed that noise stress significantly increased the lipid peroxidation and corticosterone level with concomitant depletion of GSH in the immunized rats. Noise stress significantly suppressed the CD4 and CD8 T cells in spleen and the cytokines IL2, IFN-γ and enhanced IL4 levels in the serum. The supplementation with AC as well as α-asarone prevents the noise stress induced changes in the antioxidant as well as immune status in rats. This study concludes that AC restores the noise stress induced changes which may be due to its active principle α-asarone.

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Section: Two Subsets Of T Helper Cells (Th Cells) Namelysupporting

confidence: 89%

Section: Introductionmentioning

confidence: 99%

Effect of Acorus Calamus Linn. And Its Active Principle on Noise Stress-Induced Changes on Immune System

Subramanian

2012

Int J of Biomed & Adv Res

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“…Czyrak's study confirmed that monoamine neurotransmitters play an essential role in LM and are also involved in memory retrieval 26) . Moreover, alterations in brain monoamine neurotransmitter release are associated with brain injury and cognitive impairment 27) . Acute or sub-chronic noise exposures were both found to change the level of biogenic amines in discrete regions of the rat brain 17,26) .…”

Section: Discussionmentioning

confidence: 99%

Recovery of Chronic Noise Exposure Induced Spatial Learning and Memory Deficits in Young Male Sprague‐Dawley Rats

Chen

Yan

Jiang

et al. 2011

Journal of Occupational Health

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Objective: Noise has always been an important environmental public health issue for mankind. Although reports exist on hippocampaldependent spatial learning and memory (LM) impairment due to noise, there are only a few studies that have examined the effects of recovery from noise stress on LM impairments. Therefore, the present study investigated the effects of recovery from chronic noise exposure on LM deficits. Materials and Methods: In this study, the detrimental effects of noise stress on young male rats in the Morris water maze (MWM) were investigated at 1, 10, 20, 30, and 40 days after the discontinuation of chronic noise exposure of 80 dB or 100 dB for 4 h per day, for 30 days. The levels of monoamine neurotransmitters in the hippocampus were also evaluated by HPLC-EC at the end of each behavioral test. Results: Statistical analysis revealed that rats in the noise-treated groups failed to reach the same level of performance as the controls in the MWM. Further, the levels of dopamine (DA), norepinephrine (NE) and 5-hydroxytryptamine (5-HT) were significantly decreased in the hippocampus after noise exposure. However, the reduction in monoamine levels and impaired water maze performance recovered over time, so that by 30th day after cessation of noise exposure the 80 dB group showed no performance difference from the controls, and by 40th day, the 100 dB group also showed no performance difference from the control. Conclusion:Our findings suggest that noise impaired LM in young male rats and reduced monoamine neurotransmitters in the hippocampus. However, the noise-induced water maze deficits recovered over time, and the concurrent restoration of hippocampal monoamine neurotransmitter levels suggest that they are involved in LM impairments. (J Occup Health 2011; 53: 157-163)

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“…Noise exposure firstly increases levels of ROS such as superoxide radicals, hydroxyl radicals and hydrogen peroxide (13). Long-term exposure to noise can produce excessive free radicals and reduce antioxidant status such as superoxide dismutase (SOD), catalase (CAT), glutathione (GSH) (14). Malondialdehyde (MDA) which is an indicator of lipid peroxidation processes, increases during oxidative stress.…”

Section: Introductionmentioning

confidence: 99%

Oxidative stress indices in rats’ lung tissues following simultaneous exposure to noise and styrene

Haghighat

Khavanin

Allameh

2017

JOHE

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Received: April 2017, Accepted: May 2017 Background: Simultaneous exposure to noise and organic solvents such as styrene is an indispensable part of today's industries. Numerous studies were done related to ototoxic effects of coexposure to noise and styrene while some evidences showed the adverse effects of such exposure on other organs. In this study, we aimed to assess the subacute effects of combined exposure to noise and styrene on rats' lung tissue. Materials and Methods: Twenty-four Wistar male rats were divided in four groups including: A) control, B) rats exposed to 100 dB octave band of noise, C) rats exposed to 750 ppm styrene alone, and D) rats exposed to combination of 100 dB noise and 750 ppm styrene. Following the last day of exposure, the rats were euthanized and their lung tissues were excised, homogenized and assayed for biological analysis of malondialdehyde (MDA), glutathione (GSH), catalase (CAT) and superoxide dismutase (SOD). The results were analyzed using SPSS software. Results: MDA increased significantly (P < 0.001) at the end of experiment in the group exposed to styrene and noise-styrene. GSH concentrations decreased significantly in styrene and noise-styrene group (P < 0.001). SOD (P < 0.001) and CAT (P < 0.05) activities were determined to be significantly lower for the styrene and noise-styrene groups compared to the control group. Conclusions: In conclusion, our results indicated that exposure to combination of noise and styrene caused oxidative stress, increased lipid peroxidation, and antioxidant depletion. These results appear to support the fact that co-exposure to noise and styrene might cause oxidative stress-induced damage to the lung tissue. Since simultaneous exposure to noise and styrene has an additive effect in this regard, further studies are necessary to be carried out on the effects of noise and organic solvents coexposure.

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Protective Effect of Acorus calamus LINN on Free Radical Scavengers and Lipid Peroxidation in Discrete Regions of Brain against Noise Stress Exposed Rat

Cited by 82 publications

References 35 publications

Effect of Acorus Calamus Linn. And Its Active Principle on Noise Stress-Induced Changes on Immune System

Effect of Acorus Calamus Linn. And Its Active Principle on Noise Stress-Induced Changes on Immune System

Recovery of Chronic Noise Exposure Induced Spatial Learning and Memory Deficits in Young Male Sprague‐Dawley Rats

Oxidative stress indices in rats’ lung tissues following simultaneous exposure to noise and styrene

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