Protective effect of adenosine and nicotinamide against audiogenic seizure

Maître, Michel; Ciesielski, L; Lehmann, Alice; Kempf, E.; Mandel, P.

doi:10.1016/0006-2952(74)90054-9

Cited by 166 publications

(37 citation statements)

References 14 publications

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“…The purine produces marked sedation (24,(39)(40)(41) and anticonvulsant activity (40). In addition, administration of adenosine analogues to animals produces analgesia (24,42,43).…”

Section: Discussionmentioning

confidence: 99%

Multiple components of the A1 adenosine receptor-adenylate cyclase system are regulated in rat cerebral cortex by chronic caffeine ingestion.

Ramkumar¹,

Bumgarner²,

Jacobson³

et al. 1988

J. Clin. Invest.

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“…The purine produces marked sedation (24,(39)(40)(41) and anticonvulsant activity (40). In addition, administration of adenosine analogues to animals produces analgesia (24,42,43).…”

Section: Discussionmentioning

confidence: 99%

Multiple components of the A1 adenosine receptor-adenylate cyclase system are regulated in rat cerebral cortex by chronic caffeine ingestion.

Ramkumar¹,

Bumgarner²,

Jacobson³

et al. 1988

J. Clin. Invest.

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“…In in vitro studies, adenosine depresses seizure activity in hippocampal slices (Dunwiddie, 1980). While in rodents, adenosine and its analogues protect against audiogenic (Maitre et al, 1974), chemically induced (Marangos et al, 1990;Petersen, 1991) and kindled seizures (Dragunow and Goddard, 1984). Rapid elevations in brain levels of adenosine have also been reported after experimental seizures (Schultz and Lowenstein, 1978;Winn et al, 1980) and postseizures in epileptic patients (During and Spencer, 1992).…”

Section: Discussionmentioning

confidence: 99%

“…Besides having a role in many inhibitory central mechanisms, adenosine has also been implicated in arrest of seizures. The anticonvulsant action of adenosine and its analogues has been showed both in vivo (Maitre et al, 1974;Petersen, 1991) and in vitro (Dunwiddie, 1980) studies on rodents. In addition, it has been observed that the levels of endogenous adenosine were dramatically elevated in the brain following seizures (Chin, 1989).…”

Section: Introductionmentioning

confidence: 99%

Effects of Tianeptine on Onset Time of Pentylenetetrazole-Induced Seizures in Mice: Possible Role of Adenosine A1 Receptors

Uzbay

Kayır

Ceyhan

2006

Neuropsychopharmacol

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Depression is a common psychiatric problem in epileptic patients. Thus, it is important that an antidepressant agent has anticonvulsant activity. This study was organized to investigate the effects of tianeptine, an atypical antidepressant, on pentylenetetrazole (PTZ)-induced seizure in mice. A possible contribution of adenosine receptors was also evaluated. Adult male Swiss-Webster mice (25-35 g) were subjects. PTZ (80 mg/kg, i.p.) was injected to mice 30 min after tianeptine (2.5-80 mg/kg, i.p.) or saline administration. The onset times of 'first myoclonic jerk' (FMJ) and 'generalized clonic seizures' (GCS) were recorded. Duration of 600 s was taken as a cutoff time in calculation of the onset time of the seizures. To evaluate the contribution of adenosine receptors in the effect of tianeptine, a nonspecific adenosine receptor antagonist caffeine, a specific A 1 receptor antagonist 8-cyclopentyl-1,3-dipropylxanthine (DPCPX), a specific A2 A receptor antagonist 8-(3-chlorostyryl) caffeine (CSC) or their vehicles were administered to the mice 15 min before tianeptine (80 mg/kg) or saline treatments. Tianeptine (40 and 80 mg/kg) pretreatment significantly delayed the onset time of FMJ and GCS. Caffeine (10-60 mg/kg, i.p.) dose-dependently blocked the retarding effect of tianeptine (80 mg/kg) on the onset times of FMJ and GCS. DPCPX (20 mg/kg) but not CSC (1-8 mg/kg) blocked the effect of tianeptine (80 mg/kg) on FMJ. Our results suggest that tianeptine delayed the onset time of PTZ-induced seizures via adenosine A 1 receptors in mice. Thus, this drug may be a useful choice for epileptic patients with depression.

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“…Adenosine and its receptors have wide-spread distribution in the nervous system, and receptor activation is associated with both presynaptic and postsynaptic inhibitory effects (Kuroda and McIlwain, 1977;Stone, 1981;Bender et al, 1981;Pull and McIlwain, 1974. A variety of seizure models indicate that stable adenosine analogs have potent anticonvulsant effects (Albertson et al (1983); Rosen and Berman, 1985;Dragunow and Goddard, 1985;Maitre et al, 1974;Dunwiddie and Worth, 1982;Murray et al, 1985;Burley and Ferrendelli, 1984;Turski et al, 1985).…”

Section: Damd17-88-c-8023mentioning

confidence: 99%

Regional Blood-Brain Barrier Responses to Central Cholinergic Activity

Goldman¹,

Berman²

1991

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Protective effect of adenosine and nicotinamide against audiogenic seizure

Cited by 166 publications

References 14 publications

Multiple components of the A1 adenosine receptor-adenylate cyclase system are regulated in rat cerebral cortex by chronic caffeine ingestion.

Multiple components of the A1 adenosine receptor-adenylate cyclase system are regulated in rat cerebral cortex by chronic caffeine ingestion.

Effects of Tianeptine on Onset Time of Pentylenetetrazole-Induced Seizures in Mice: Possible Role of Adenosine A1 Receptors

Regional Blood-Brain Barrier Responses to Central Cholinergic Activity

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