Protective effect of Alpha‐Linolenic acid on Lipopolysaccharide‐Induced Orchitis in mice

Ok, Fesih; Kaplan, Halil Mahir; Kizilgok, Bahattin; Demir, Erkan

doi:10.1111/and.13667

Cited by 14 publications

(10 citation statements)

References 23 publications

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“…47 Furthermore, ALA can inhibit the translocation of NF-κB and the phosphorylation of MAPK, and finally reduced the expression of inflammatory factors such as cyclooxygenase-2 (COX-2) and TNF-α. 48 These results are also similar to the finding in the present research that ALA as the main component can inhibit the inflammatory cytokine (IL-6 and TNF-α) release in the inflammation cell model.…”

Section: Discussionsupporting

confidence: 92%

The fatty acid profiles of mixed fermented milk and its anti-inflammation properties in an LPS-induced RAW264.7 cell model

et al. 2022

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Section: Discussionsupporting

confidence: 92%

The fatty acid profiles of mixed fermented milk and its anti-inflammation properties in an LPS-induced RAW264.7 cell model

et al. 2022

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“…For the DSS‐induced ulcerative colitis mice, ALA (30–60 mg/kg) also reduced the expression of IL‐6, COX‐2, TNF‐α, and M1‐positive macrophages (J. Kim et al, 2020; Reifen, Karlinsky, Stark, Berkovich, & Nyska, 2015). Also, ALA (10–200 mg/kg) improved LPS‐induced orchitis and cystitis in mice through the reduced expression of IL‐6, TNF‐α, COX‐2, PLA 2 , and iNOS by inhibiting the activation of the NF‐κB signaling pathway (Kapl, Ok, & Demir, 2017; Ok, Kaplan, Kizilgok, & Demir, 2020). ALA (360–1800 mg/kg) improved lung injury in LPS‐induced mice by reducing the infiltration of total cells and neutrophils, increasing the number of macrophages, and inhibiting the expression of TNF‐α, IL‐6, and IL‐1β (Zhu et al, 2020).…”

Section: Pharmacological Effectsmentioning

confidence: 99%

The review of alpha‐linolenic acid: Sources, metabolism, and pharmacology

Yuan

Xie

Huang

et al. 2021

Phytotherapy Research

129

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α‐linolenic acid (ALA, 18:3n‐3) is a carboxylic acid composed of 18 carbon atoms and three cis double bonds, and is an essential fatty acid indispensable to the human body. This study aims to systematically review related studies on the dietary sources, metabolism, and pharmacological effects of ALA. Information on ALA was collected from the internet database PubMed, Elsevier, ResearchGate, Web of Science, Wiley Online Library, and Europe PMC using a combination of keywords including “pharmacology,” “metabolism,” “sources.” The following findings are mainly contained. (a) ALA can only be ingested from food and then converted into eicosapentaenoic acid and docosahexaenoic acid in the body. (b) This conversion process is relatively limited and affected by many factors such as dose, gender, and disease. (c) Pharmacological research shows that ALA has the anti‐metabolic syndrome, anticancer, antiinflammatory, anti‐oxidant, anti‐obesity, neuroprotection, and regulation of the intestinal flora properties. (d) There are the most studies that prove ALA has anti‐metabolic syndrome effects, including experimental studies and clinical trials. (e) The therapeutic effect of ALA will be affected by the dosage. In short, ALA is expected to treat many diseases, but further high quality studies are needed to firmly establish the clinical efficacy of ALA.

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“…Likewise, linolenic acid (V83) was assumed to be transformed into methyl linolenate (V82) by esterification reaction during stir-frying [ 38 ]. Previous study has reported that linolenic acid shows bioactivities such as anti-inflammatory and antioxidant effects [ 40 ]. Therefore, it might be also related to the disappearance or significant decrease of linolenic acid ( Table 2 ) and efficacy changing under the stir-fry processing of SS.…”

Section: Resultsmentioning

confidence: 99%

The Potential Transformation Mechanisms of the Marker Components of Schizonepetae Spica and Its Charred Product

Liu

Ying

et al. 2020

Molecules

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Schizonepetae Spica (SS) is commonly used for treating colds, fevers, bloody stool and metrorrhagia in China. To treat colds and fevers, traditional Chinese medicine doctors often use raw SS, while to treat bloody stool and metrorrhagia, they usually use Schizonepetae Spica Carbonisata (SSC; raw SS processed by stir-frying until carbonization). However, there have been limited investigations designed to uncover the mechanism of stir-fry processing. In the present study, a method combining gas chromatography-mass spectrometry (GC-MS) and high-performance liquid chromatography (HPLC) was developed for the comprehensive analysis of the chemical profiles of SS and SSC samples. Principal component analysis of the GC-MS data demonstrated that there were 16 significant differences in volatile compounds between the SS and SSC samples. The simultaneous quantification of six nonvolatile compounds was also established based on HPLC, and remarkable differences were found between the two products. These changes were probably responsible for the various pharmacological effects of SS and SSC as well as the observed hepatotoxicity. Finally, the mechanisms could be rationalized by deducing possible reactions involved in the transformation of these marker components. This work reports a new strategy to reveal the chemical transformation of SS during stir-fry processing.

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Protective effect of Alpha‐Linolenic acid on Lipopolysaccharide‐Induced Orchitis in mice

Cited by 14 publications

References 23 publications

The fatty acid profiles of mixed fermented milk and its anti-inflammation properties in an LPS-induced RAW264.7 cell model

The fatty acid profiles of mixed fermented milk and its anti-inflammation properties in an LPS-induced RAW264.7 cell model

The review of alpha‐linolenic acid: Sources, metabolism, and pharmacology

The Potential Transformation Mechanisms of the Marker Components of Schizonepetae Spica and Its Charred Product

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