Protective effect of aminoguanidine against cyclophosphamide-induced oxidative stress and renal damage in rats

Abraham, Premila; Rabi, Suganthy

doi:10.1179/174329211x12968219310837

Cited by 32 publications

(19 citation statements)

References 44 publications

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“…For evaluating the antioxidant activity in renal tissue, we measured the renal GSH level, SOD, GPx and CAT activity. Earlier studies have demonstrated that CPinduced nephrotoxicity is associated with depletion of renal antioxidant enzymes such as CAT, SOD, GPx and GSH [5,49]. Our results are in line with the previous studies indicating that a decrease in renal antioxidant enzymes is apparent in treatment with CP.…”

Section: Discussionsupporting

confidence: 93%

Pretreatment with melatonin protects against cyclophosphamide‐induced oxidative stress and renal damage in mice

Goudarzi

Khodayar

Tabatabaei

et al. 2017

Fundamemntal Clinical Pharma

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Cyclophosphamide (CP) is widely used in treatment of different cancers. Nephrotoxicity is one of the dose-limiting side effects of CP. This study was carried out to investigate the effect of melatonin (MEL) on CP-induced nephrotoxicity in mice. In this study, 50 Swiss albino mice (20-25 g) were randomly divided into five groups. Mice were pretreated with MEL intraperitoneally (i.p) in doses of 5, 10 and 20 mg/kg for five consecutive days, and CP (200 mg/kg, i.p) was administrated on the 5th day 1 h after the last dose of MEL. Then on day 6, blood samples were collected to determine serum creatinine (Cr) and blood urea nitrogen (BUN) levels. The kidneys were used for histological examination, biochemical assays and real-time PCR studies. Malondialdehyde (MDA), glutathione (GSH), protein carbonyl (PC), nitric oxide (NO) level, catalase (CAT), superoxide dismutase (SOD), glutathione peroxidase (GPx) and myeloperoxidase (MPO) activity were assessed in renal tissue. In addition, the expression of SOD2 and PGx1 was measured using real-time PCR method in renal tissue. Results showed that CP administration significantly increases Cr, BUN, MDA, PC, NO level and MPO activity. It also decreases renal GSH level, SOD, GPx and CAT activity. Pretreatment with MEL (especially 20 mg/kg, i.p.) for 5 days prevented these changes; however, it did not affect the SOD activity. Our results revealed that MEL might be useful for prevention of the nephrotoxicity induced by CP through ameliorative effects on biochemical indices and oxidative stress parameters.

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Section: Discussionsupporting

confidence: 93%

Pretreatment with melatonin protects against cyclophosphamide‐induced oxidative stress and renal damage in mice

Goudarzi

Khodayar

Tabatabaei

et al. 2017

Fundamemntal Clinical Pharma

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“…The OS induced by CP in testicular tissue of treated rats in this study was agreed with that previously demonstrated by Abraham and Rabi [22] and Nitharwal et al [23] who concluded that exposure of rats to CP can disrupt the reduction-oxidation (redox) balance in the tissues leading to oxidative stress. Our results are comparable with Ilbey et al [24] who reported that treatment with the anticancer CP resulted in elevated levels of MDA due to the excessive generation of free radicals and reduced levels of GSH, CAT and SOD activities in testis.…”

Section: Discussionsupporting

confidence: 92%

Ameliorative Effects of Curcumin-Zinc Oxide Nanoparticles Conjugate on Cyclophosphamide-Induced Infertility in Male Rats

Ahmad

El-Aziz

El-Emam

2019

Zagazig Veterinary Journal

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The present study aimed to investigate the ameliorative effects of Curcumin-ZnO NPs conjugate on testicular tissue damage induced by the anticancer cyclophosphamide. Seventy adult male albino rats weighing 150±15g were used in this study; 10 of them served as a control and 60 rats were intraperitoneal injected with cyclophosphamide at a dose of 30 mg/kg BW every other alternative day for 14 days. They were subdivided into CP group, CP + Curcumin NPs (15 mg/kg B.W), CP + ZnO NPs (10 mg/kg B.W), CP + Curcumin-ZnO NPs conjugate (10 mg/kg B.W), CP + Curcumin-ZnO NPs conjugate (15 mg/kg BW) and CP + Curcumin-ZnO NPs conjugate (20 mg/kg B.W) group. All treatments were given for 30 days. The results reported that curcumin-ZnO NPs conjugate treatment at doses of 15 and 20 mg/kg BW exhibited significant increase in sperm motility percent, sperm count, testicular antioxidant enzymes activities and serum testosterone and FSH levels and significant decrease in sperm abnormalities percent compared to cyclophosphamide treated rats. It was concluded that curcumin-ZnO NPs conjugate at doses of 15 and 20 mg/kg B.W ameliorate the testicular tissue damage induced by the anticancer cyclophosphamide.

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“…Aminoguanidine can primarily scavenge reactive dicarbonyl precursors to AGEs and inhibit the formation of AGEs . It may also inhibit lipid peroxidation and protein oxidation, and protect the activities of antioxidant enzymes including GPx, catalase and GSTase and also MPO, thus preventing inflammation damage . Besides, aminoguanidine also improves neutrophil migration into diabetic wound.…”

Section: Introductionmentioning

confidence: 99%

AGEs and chronic subclinical inflammation in diabetes: disorders of immune system

Jiang

Ren

et al. 2015

Diabetes Metabolism Res

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Chronic subclinical inflammation represents a risk factor of type 2 diabetes and several diabetes complications, including neuropathy and atherosclerosis including macro-vasculopathy and micro-vasculopathy. However, the inflammatory response in the diabetic wound was shown to be remarkably hypocellular, unregulated and ineffective. Advanced glycation end products (AGEs) and one of its receptors, RAGE, were involved in inducing chronic immune imbalance in diabetic patients. Such interactions attracts immune cell into diffused glycated tissue and activates these cells to induce inflammatory damage, but disturbs the normal immune rhythm in diabetic wound. Traditional measurements of AGEs are high-performance liquid chromatography and immunohistochemistry staining, but their application faces the limitations including complexity, cost and lack of reproducibility. A new noninvasive method emerged in 2004, using skin autofluorescence as indicator for AGEs accumulation. It had been reported to be informative in evaluating the chronic risk of diabetic patients. Studies have indicated therapeutic potentials of anti-AGE recipes. These recipes can reduce AGE absorption/de novo formation, block AGE-RAGE interaction and arrest downstream signaling after RAGE activation.

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Protective effect of aminoguanidine against cyclophosphamide-induced oxidative stress and renal damage in rats

Abstract: The results of the present study reveal that AG can prevent CP-induced renal damage by inhibiting oxidative stress. Thus, AG may be useful for prevention of the nephrotoxicity of CP.

Cited by 32 publications

References 44 publications

Pretreatment with melatonin protects against cyclophosphamide‐induced oxidative stress and renal damage in mice

Pretreatment with melatonin protects against cyclophosphamide‐induced oxidative stress and renal damage in mice

Ameliorative Effects of Curcumin-Zinc Oxide Nanoparticles Conjugate on Cyclophosphamide-Induced Infertility in Male Rats

AGEs and chronic subclinical inflammation in diabetes: disorders of immune system

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