Protective effect of antioxidants on pulmonary endothelial function after cardiopulmonary bypass

Angdin, Monika; Settergren, G.; Starkopf, Joel; Zilmer, Mihkel; Zilmer, Kersti; Vaage, Jarle

doi:10.1016/s1053-0770(03)00053-3

Cited by 38 publications

(21 citation statements)

References 24 publications

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“…In the absence of functional parameters of pulmonary function such as pulmonary index or aleveolararterial oxygen tension difference (A-aDO2), this too seems speculative but our observations are strengthened by previous studies, which have shown that antioxidants, such as allopurinol, protect the lungs by decreasing pulmonary endothelial dysfunction after CPB [10].…”

Section: Discussionmentioning

confidence: 46%

Effect of preoperative administration of allopurinol in patients undergoing surgery for valvular heart diseases☆

Talwar

Sandeep

Choudhary

et al. 2010

European Journal of Cardio-Thoracic Surgery

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The administration of allopurinol prior to OHS for valvular heart diseases is associated with increased conversion and maintenance to normal sinus rhythm, reduced inotropic score and a reduction in the duration of mechanical ventilation and hospital stay. There was, however, no significant difference in the blood levels of CPK-MB and troponin T and a large sample size is required to assess this further.

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Section: Discussionmentioning

confidence: 46%

Effect of preoperative administration of allopurinol in patients undergoing surgery for valvular heart diseases☆

Talwar

Sandeep

Choudhary

et al. 2010

European Journal of Cardio-Thoracic Surgery

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“…Kretzschmar M, et al 7 had studied the effect of NAC (150mg/kg) on ischemiareperfusion syndrome in patients undergoing abdominal aortic aneurysmectomy and concluded that mean PAP in the control group were significantly higher when compared to the NAC treated group. Angdin et al, 29 had demonstrated that thiol supplementation with NAC reduces endothelial dysfunction and thereby improves endothelium dependant vasodilation.…”

Section: Discussionmentioning

confidence: 99%

Effect of N - Acetylcysteine on Pulmonary Function in Patients Undergoing Off Pump Coronary Artery Bypass Grafting

Jalakandan¹,

Bhaskaran²

2015

jemds

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OBJECTIVE:Postoperative lung injury is one of the most frequent complications of cardiac surgery. Increasingly used Off Pump Coronary Artery Bypass Grafting (OPCABG) has significantly reduced the oxidative stress and the inflammatory response associated with the use of cardiopulmonary bypass (CPB). However, OPCABG is also associated with significant oxidative stress and its related complications. The present study is a prospective, randomized, double blind investigating the effects of N-acetylcysteine (NAC), a potent anti-oxidant on pulmonary functions in patients undergoing OPCABG. METHODS: Fifty patients undergoing elective OPCABG were randomized into two groups. Group A (n=25), the control group received 200ml of Normal saline immediately following induction whereas Group B (n=25), the study group received 150mg/kg of NAC in 200ml of Normal saline at the same time. Pulmonary Capillary Wedge Pressure (PCWP), Pulmonary Artery Pressure (PAP), Dynamic lung compliance (C Dyn), Static lung compliance (C Stat), Alveolar -arterial oxygen gradient (A-a Do2) were measured immediately following induction, after admission into ICU, and then 4 th hourly till extubation. Malondialdehyde (MDA) and Glutathione (GSH) levels were assayed once immediately following induction and again immediately after shifting to ICU. RESULTS: Demographic profile, pre-incision clinical and biochemical values were comparable in both the groups. PCWP, PAP-Diastole were lower and C Dyn and C Stat were significantly higher in study group when compared to control group. No difference in PAP-Systole was found. Both the groups had increased A-a Do2, but the increase was significantly lower in the study group. At the end of surgery, MDA levels were significantly raised in control group (p<0.001) whereas its levels were maintained in study group (p<0.569). GSH levels were significantly decreased in control group (p<0.001) whereas its levels were significantly increased in study group (p<0.001). CONCLUSION: OPCABG was associated with significant oxidative response but the administration of NAC attenuates this stress response by replenishing the GSH stores. NAC improves pulmonary function in terms of increased compliance and increased systemic oxygenation.

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“…Protein measurements and oxidative stress indexes were determined according to the method documented in previous studies [21][22][23][24][25][26][27]. The myeloperoxidase (MPO) activity is expressed as U/g wet tissue.…”

Section: Assays Of Oxidative Stress Markersmentioning

confidence: 99%

“…However, most of them investigated liver IR, toxic drug induced hepatic injury, or acute inflammation models [11-13, 21, 22, 26]. Furthermore, several recent clinical trials concentrated on the effects of NAC and melatonin in CPB patients, and their results were encouraging [23,27,28]. However, such clinical trials could not provide the morphology of tissues because of ethics restriction and some uncontrolled influencing factors.…”

Section: Figmentioning

confidence: 99%

Protective Effects of Melatonin and N-Acetylcysteine on Hepatic Injury in a Rat Cardiopulmonary Bypass Model

Huang

Yin

Zhu

et al. 2007

Journal of Surgical Research

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Protective effect of antioxidants on pulmonary endothelial function after cardiopulmonary bypass

Cited by 38 publications

References 24 publications

Effect of preoperative administration of allopurinol in patients undergoing surgery for valvular heart diseases☆

Effect of preoperative administration of allopurinol in patients undergoing surgery for valvular heart diseases☆

Effect of N - Acetylcysteine on Pulmonary Function in Patients Undergoing Off Pump Coronary Artery Bypass Grafting

Protective Effects of Melatonin and N-Acetylcysteine on Hepatic Injury in a Rat Cardiopulmonary Bypass Model

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