Protective effect of Aquilegia vulgaris (L.) on APAP-induced oxidative stress in rats

Protective effects of IranianAchillea wilhelmsiiessential oil on acetaminophen-induced oxidative stress in rat liver

“…These results confirmed the role of APAP metabolism in increasing the oxidative stress leading to oxidative stress/antioxidants statue imbalance (Dai et al, 2006;Jodynis-Liebert et al, 2005;Kumari & Kakkar, 2012). The toxicity of APAP is related to its bioactivation by cytochrome P450 to the electrophilic metabolite N-acetyl parabenzoquinone imine (NAPQI).…”

“…Other studies also indicated that essential oils could modulate the oxidative stress/antioxidant statues. Protective effect of Aquilegia vulgaris L. (Ranunculaceae) on APAP-induced oxidative stress in rats is mediated by amelioration of microsomal LP and restoring antioxidant enzymes activity (Jodynis-Liebert et al, 2005). Lupeol, a triterpene, when co-administered with APAP, effectively reduces oxidative stress and prevents APAP-induced hepatotoxicity by inhibiting critical control points of apoptosis (Kumari & Kakkar, 2012).…”

Hepatoprotective effects of Iranian Hypericum scabrum essential oils against oxidative stress induced by acetaminophen in rats

“…The protective effects of quercetin and curcumin on paracetamol-induced liver injury in the rat through modulating the oxidative stress/ antioxidant parameters has also been reported (Yousef et al 2010). The protective effect of Aquilegia vulgaris (L.) on APAP-induced oxidative stress in rats was mediated by amelioration of microsomal lipid peroxidation and restoring the antioxidant enzymes activity (Jodynis-Liebert et al 2005). These data were confirmed by histopathological examinations (Fig.…”

Effect of Aquilegia vulgaris (L.) ethyl ether extract on liver antioxidant defense system in rats

“…Another theory states that NAPQI is an oxidizing agent that depletes GSH, a cellular protectant against reactive oxygen species (ROS), thus leading to oxidative stress [29]. Our previous investigation has demonstrated that the ethanol and ethyl acetate extracts as well as isocytisoside obtained from A. vulgaris attenuated the effects of APAP-and CCl 4 -induced hepatic injury by restoring the activity of most of the antioxidant enzymes and by inhibiting microsomal lipid peroxidation [13,14]. The present study was undertaken to evaluate the potential protective effect of ethyl ether extract from Aquilegia vulgaris on APAP-induced hepatotoxicity in rats.…”

“…The predominant compound was 4'-methoxy-5,7-dihydroxyflavone 6-C-glucopyranoside (isocytisoside) [6]. Our previous studies have demonstrated that ethanol and ethyl acetate extracts, and isocytisoside isolated from A. vulgaris attenuated the effects of CCl 4 -and APAP-induced hepatic injury by restoring the activity of most of the antioxidant enzymes and by inhibiting microsomal lipid peroxidation [13,14]. The present study was undertaken to evaluate the potential protective effects of ether ethyl extract from A. vulgaris on APAP-induced hepatotoxicity.…”