Protective Effect of Artemisia judaica against Doxorubicin-Induced Toxicity in Mice

Ahmed, Ehab A.; Mabrouk, Dalia M.; Hassanane, Mahrousa M.; Khalil, Wagdy K. B.

doi:10.9734/arrb/2017/35990

Cited by 8 publications

(8 citation statements)

References 27 publications

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“…Moreover, the cytotoxic activity of the alcoholic crude extract was previously reported against hepatocellular carcinoma (HepG2), breast cancer (MCF-7), and colon tumor (LoVo) cell lines. This was explained through its ability to inhibit cell proliferation, angiogenesis, and inflammation in addition to its a beneficial protective effect against doxorubicin-induced toxicity in mice [ 15 , 16 , 17 , 18 , 19 ]. Both the ethyl acetate and petroleum ether fractions exhibited remarkable renal protective activity in hyperlipidemic and hyperglycemic rats [ 20 ].…”

Section: Introductionmentioning

confidence: 99%

In Vitro and In Vivo Studies of Anti-Lung Cancer Activity of Artemesia judaica L. Crude Extract Combined with LC-MS/MS Metabolic Profiling, Docking Simulation and HPLC-DAD Quantification

et al. 2021

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Artemisia judaica L. (Family: Asteraceae) exhibited antioxidant, anti-inflammatory, and antiapoptotic effects. The in vitro cytotoxic activity of A. judaica ethanolic extract was screened against a panel of cancer cell lines. The results revealed its cytotoxic activity against a lung cancer (A549) cell line with a promising IC50 of 14.2 μg/mL compared to doxorubicin as a standard. This was confirmed through the downregulation of antiapoptotic genes, the upregulation of proapoptotic genes, and the cell cycle arrest at the G2/M phase. Further in vivo study showed that a solid tumor mass was significantly reduced, with a tumor inhibition ratio of 54% relative to doxorubicin therapy in a Xenograft model. From a chemical point of view, various classes of natural products have been identified by liquid chromatography combined with tandem mass spectrometry (LC-MS/MS). The docking study of the detected metabolites approved their cytotoxic activity through their virtual binding affinity towards the cyclin-dependent kinase 2 (CDK-2) and epidermal growth factor receptor (EGFR) active sites. Finally, A. judaica is a fruitful source of polyphenols that are well-known for their antioxidant and cytotoxic activities. As such, the previously reported polyphenols with anti-lung cancer activity were quantified by high-performance liquid chromatography coupled with a diode array detector (HPLC-DAD). Rutin, quercetin, kaempferol, and apigenin were detected at concentrations of 6 mg/gm, 0.4 mg/gm, 0.36 mg/gm, and 3.9 mg/gm of plant dry extract, respectively. It is worth noting that kaempferol and rutin are reported for the first time. Herein, A. judaica L. may serve as an adjuvant therapy or a promising source of leading structures in drug discovery for lung cancer treatment.

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Section: Introductionmentioning

confidence: 99%

In Vitro and In Vivo Studies of Anti-Lung Cancer Activity of Artemesia judaica L. Crude Extract Combined with LC-MS/MS Metabolic Profiling, Docking Simulation and HPLC-DAD Quantification

et al. 2021

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“…E. spinosus is a perennial spiny herb; its preparations were used in traditional medicine as an abortifacient, anti-diabetic and diuretic and to improve blood circulation [35]. A. judaica is a perennial aromatic shrub commonly used as an anti-helminthic and reported to have anti-microbial, anti-inflammatory, anti-oxidant [36] and anti-diabetic effects [37]. No previous studies have investigated the anti-protozoal potential of these herbs on Blastocystis spp.…”

Section: Introductionmentioning

confidence: 99%

Anti-Blastocystis Activity In Vitro of Egyptian Herbal Extracts (Family: Asteraceae) with Emphasis on Artemisia judaica

Mokhtar

Ahmed

Eltamany

et al. 2019

IJERPH

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Achillea fragrantissima (Forssk.) Sch. Bip. (known as Qaysoom), Echinops spinosus L. (known as Shoak Elgamal) and Artemisia judaica L. (known Shih Baladi) are members of the Asteraceae family known for their traditional medical use in Egypt. The ethanol extracts of these plants were evaluated for their efficacy against a protozoan parasite (Blastocystis). Two different molecular subtypes of Blastocystis were used (ST1 and ST3). Significant growth inhibition of Blastocystis was observed when exposed to both A. judaica (99.3%) and A. fragrantissima (95.6%) with minimal inhibitory concentration (MIC90) at 2000 µg/mL. Under the effect of the extracts, changes in Blastocystis morphology were noted, with the complete destruction of Blastocystis forms after 72 h with the dose of 4000 µg/mL. Different subtypes displayed different responses to the herbal extracts tested. ST1 exhibited significantly different responses to the herbal extracts compared to ST3. A. judaica was selected as the herb of choice considering all of its variables and because of its effective action against Blastocystis. It was then exposed to further fractionation and observation of its effect on ST1 and ST3. Solvent portioned fractions (dichloromethane (DCM), ethyl acetate (EtOAc) and n-hexane) in A. judaica were found to be the potent active fractions against both of the Blastocystis subtypes used.

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“…These findings are in agreement with previous reports which showed that A. Judaica protected against organs damage and cellular enzymes leakage in rodents through its membrane-stabilizing property . 8,19,39 The protective effect of A. judaica against diabetes-mediated cardiac injury was further confirmed by the histological findings. H&E stained sections in the heart of both control ( Figure 3A) and A. judaicaadministrated rats ( Figure 3B) showed normal morphological features microscopically.…”

Section: A Judaica Protects Against Hyperglycaemia-induced Cardiac Imentioning

confidence: 79%

“…Remarkably, A. judaica treatment attenuated MDA and boosted antioxidants in the hearts of diabetic rats. In this context, A. judaica attenuated hyperglycaemia 8,35 and doxorubicin 19 induced tissue injury by suppressing lipid peroxidation and restoration of endogenous antioxidants. 17 These findings indicate that A. judaica could protect against cardiac injury by attenuating oxidative stress, which could be attributed to its antioxidant and antiperoxidative properties.…”

Section: A Judaica Attenuates Myocardial Oxidative Stress In Diabetimentioning

confidence: 99%

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Artemisia judaica Attenuates Hyperglycaemia-Mediated Oxidative Stress and Cardiac Injury in Streptozotocin-Induced Diabetic Rats

2020

TJNPR

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Diabetes mellitus (DM) is a metabolic disorder characterised by hyperglycaemia and associated with numerous acute and chronic complications such as nephropathy, retinopathy and cardiomyopathy. Diabetic cardiomyopathy (DCM) as one of the common long-term diabetic consequences involves various pathological changes in the myocardium that eventually lead to heart failure. 1,2 Hyperglycaemia-mediated oxidative stress plays a crucial role in the pathophysiological mechanisms underlying myocardial damage in diabetic cardiomyopathy. 2,3 Excess reactive oxygen species (ROS) stimulate the inflammatory process and apoptotic death pathways activation eventually culminating in myocardial damage and development of DCM. 3-5 Therefore, scavenging of ROS by antioxidants has gained much attention as a promising approach to attenuate DCM and other diabetes complications which are mediated by oxidative damage. Artemisia judaica L. (A. judaica) belongs to the family Asteraceae and Artemisia genera which are widely used in folk medicine being recommended by Bedouins in Middle Eastern countries where it is known by the Arabic name "Al-ba'atharan". 6 Traditionally, it is widely used for the treatment of gastro-intestinal disorders, heart diseases, erectile dysfunction, diabetes mellitus, wound healing, and inflammatory related diseases such as arthritis. 7 Extracts and isolated compounds from A. judaica have exhibited various biological and

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Protective Effect of Artemisia judaica against Doxorubicin-Induced Toxicity in Mice

Cited by 8 publications

References 27 publications

In Vitro and In Vivo Studies of Anti-Lung Cancer Activity of Artemesia judaica L. Crude Extract Combined with LC-MS/MS Metabolic Profiling, Docking Simulation and HPLC-DAD Quantification

In Vitro and In Vivo Studies of Anti-Lung Cancer Activity of Artemesia judaica L. Crude Extract Combined with LC-MS/MS Metabolic Profiling, Docking Simulation and HPLC-DAD Quantification

Anti-Blastocystis Activity In Vitro of Egyptian Herbal Extracts (Family: Asteraceae) with Emphasis on Artemisia judaica

Artemisia judaica Attenuates Hyperglycaemia-Mediated Oxidative Stress and Cardiac Injury in Streptozotocin-Induced Diabetic Rats

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