Protective effect of atorvastatin on d-galactose-induced aging model in mice

Kaviani, Elham; Rahmani, Mohammadreza; Kaeidi, Ayat; Shamsizadeh, Ali; Allahtavakoli, M; Mozafari, Nazanin; Fatemi, Iman

doi:10.1016/j.bbr.2017.07.029

Cited by 46 publications

(42 citation statements)

References 60 publications

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“…This suggests that the beneficial effects of CAW may not be restricted to the hippocampus as both the hippocampus and cortex are known to play an important role in object recognition memory (Aggleton, Albasser, Aggleton, Poirier, & Pearce, ; Buckmaster, Eichenbaum, Amaral, Suzuki, & Rapp, ; Clark, Zola, & Squire, ; Hammond, Tull, & Stackman, ). Age‐related impairments in object recognition are seen in both rodents and humans (Diaz et al., ; Kaviani et al., ; Li et al., ; Merriman, Ondřej, Roudaia, O'Sullivan, & Newell, ; Singh & Thakur, ). While to our knowledge this is the first report of Centella asiatica affecting recognition memory in aged rodents, it has been demonstrated that performance in the NORT is improved following administration of other polyphenol‐containing plant extracts (Carey et al., ; Matias et al., ; Nam et al., ; Yu et al., ).…”

Section: Discussionmentioning

confidence: 99%

Centella asiatica increases hippocampal synaptic density and improves memory and executive function in aged mice

et al. 2018

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Introduction Centella asiatica is a plant used for centuries to enhance memory. We have previously shown that a water extract of Centella asiatica (CAW) attenuates age‐related spatial memory deficits in mice and improves neuronal health. Yet the effect of CAW on other cognitive domains remains unexplored as does its mechanism of improving age‐related cognitive impairment. This study investigates the effects of CAW on a variety of cognitive tasks as well as on synaptic density and mitochondrial and antioxidant pathways.MethodsTwenty‐month‐old CB6F1 mice were treated with CAW (2 mg/ml) in their drinking water for 2 weeks prior to behavioral testing. Learning, memory, and executive function were assessed using the novel object recognition task (NORT), object location memory task (OLM), and odor discrimination reversal learning (ODRL) test. Tissue was collected for Golgi analysis of spine density as well as assessment of mitochondrial, antioxidant, and synaptic proteins.ResultsCAW improved performance in all behavioral tests suggesting effects on hippocampal and cortical dependent memory as well as on prefrontal cortex mediated executive function. There was also an increase in synaptic density in the treated animals, which was accompanied by increased expression of the antioxidant response gene NRF2 as well as the mitochondrial marker porin.ConclusionsThese data show that CAW can increase synaptic density as well as antioxidant and mitochondrial proteins and improve multiple facets of age‐related cognitive impairment. Because mitochondrial dysfunction and oxidative stress also accompany cognitive impairment in many pathological conditions this suggests a broad therapeutic utility of CAW.

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Section: Discussionmentioning

confidence: 99%

Centella asiatica increases hippocampal synaptic density and improves memory and executive function in aged mice

et al. 2018

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“…At the end to the test, the apparatus was cleaned up with a 5% ethanol solution. Anxiety‐like behavior was assessed through two parameters: percentage of time spent on the open arms (OAT%) and the percentage of entries into the open arms (OAE%; any increase in the OAT% and/or OAE% was considered as anxiolytic‐like behavior) …”

Section: Methodsmentioning

confidence: 99%

Pro‐neurocognitive and anti‐sarcopenic benefits of one‐year metformin therapy in ovariectomized aged mice

Zakeri

Fatemi

Kaeidi

et al. 2019

Clin Exp Pharma Physio

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Health promotion and healthy nutrition significantly increased life expectancy around the world. Aging is associated with an increase in age-related diseases. The use of metformin (Met) as an anti-aging drug has recently been proposed based on its widespread use in clinical practice. Reports have shown that Met acts as an antiaging agent. In this study, the effects of long-term, 1 year, Met administration on aging-related behaviors and longevity in ovariectomized mice was studied. Met (1 and 10 mg/kg, daily) was administered orally in ovariectomized mice. The anxiety-like behavior, working memory, and physical strength were measured through elevated plus maze, Y-maze, vertical grid holding, and the obligatory swimming capacity tests.Brains were harvested to measure brain-derived neurotrophic factor (BDNF) level.Also, the Kaplan-Meier survival curves were used to show differences and similarities in survival patterns. Met (10 mg/kg) decreased anxiety-like behaviors as well as increased muscle strength and working memory in the ovariectomized mice. Moreover, Met increased the physical strength and longevity as well as the level of BDNF in the ovariectomized mice. Our results indicate that Met administration can be an effective strategy for having a healthy aging in the absence of female gonadal hormones and reverses deleterious effects of ovariectomy-induced aging possibly through BDNF. K E Y W O R D Saging, brain-derived neurotrophic factor, metformin, ovariectomy

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“…d ‐gal was dissolved in a controlled volume of mice drinking water. d ‐gal was administered at the dose of 500 mg/kg in 10 ml drinking water for 6 weeks . Met was freshly prepared in standard drinking water (10 mL/kg) and administered orally once a day .…”

Section: Methodsmentioning

confidence: 99%

Metformin ameliorates the age‐related changes of d‐galactose administration in ovariectomized mice

Fatemi

Heydari

Kaeidi

et al. 2018

Fundamemntal Clinical Pharma

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Metformin (Met) has been shown to have pleiotropic effects such as neuroprotective, antioxidant, and anti-inflammatory properties making that a potential candidate for the treatment of central nervous system (CNS) disorders. This study was designed to investigate the possible effect of Met on the d-galactose (d-gal)-induced aging in ovariectomized mice. The female mice underwent bilateral ovariectomy. d-gal was administered orally at a dose of 500 mg/kg, and Met was administrated orally at doses of 1 and 10 mg/kg for 6 weeks. Anxiety-like behavior was evaluated by the elevated plus-maze. Physical power was assessed by vertical grid holding test and forced swimming capacity test. The brains were assessed for the level of superoxide dismutase (SOD) and brain-derived neurotrophic factor (BDNF). Ovariectomy caused anxiety and declined the physical power as well as BDNF and SOD levels. d-gal administration in ovariectomized mice exacerbated these deleterious effects. Met hampered the anxiety-like behavior and strengthened the physical power of d-gal-treated ovariectomized mice. Met also increased the SOD and BDNF levels in the brains of d-gal-treated ovariectomized animals. Based on the obtained results, we suggest Met administration as a novel therapeutic approach for the treatment of age-related conditions in the absence of female sex hormones.

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Protective effect of atorvastatin on d-galactose-induced aging model in mice

Cited by 46 publications

References 60 publications

Centella asiatica increases hippocampal synaptic density and improves memory and executive function in aged mice

Centella asiatica increases hippocampal synaptic density and improves memory and executive function in aged mice

Pro‐neurocognitive and anti‐sarcopenic benefits of one‐year metformin therapy in ovariectomized aged mice

Metformin ameliorates the age‐related changes of d‐galactose administration in ovariectomized mice

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