Protective effect of baicalein against endotoxic shock in rats in vivo and in vitro

Baicalein, an active component of Scutellaria baicalensis Georgi, improves cardiac contractile function in endotoxaemic rats via induction of heme oxygenase-1 and suppression of inflammatory responses

“…In a previous study, we showed that baicalein improves circulatory failure and the survival rate in septic rats (Cheng et al, 2007). Here, we further investigated the cardioprotective effect of baicalein during endotoxaemia, which may directly contribute to prevention of circulatory failure.…”

“…The dose of baicalein used was based on our previous study on sepsis (Cheng et al, 2007). Bacterial LPS (Escherichia coli serotype 0127:B8, L3127) and baicalein were obtained from Sigma Chemical Company (St. Louis, MO, USA).…”

“…In an in vitro study, baicalein suppressed the LPS-induced production of NO in RAW264.7 mouse macrophages (Wakabayashi, 1999). Recently, we reported that baicalein reduces plasma NO levels in vivo in septic rats, leading to improved vasoreactivity, blood pressure and survival rate (Cheng et al, 2007). However, it is uncertain whether the beneficial effect of baicalein on cardiac contractile function directly contributes to the prevention of circulatory failure.…”

Changes in intestinal mucosal immune barrier in rats withendotoxemia

“…In accordance with the study of Cheng et al [13] , endotoxemia was induced by a single caudal venous injection of LPS at 10 mg/kg, while control animals received caudal venous injections of saline. Ten animals were sacrificed in each group at each time point (2, 6, 12 and 24 h) after LPS infusion.…”

Eriodictyol, a Plant Flavonoid, Attenuates LPS-Induced Acute Lung Injury Through Its Antioxidative and Antiinflammatory Activity

“…The survival rate, which was strongly indicative of the protective effect of eriodictyol on LPS-induced ALI, was examined in differentially treated ALI mice as previously described (31). It was found that, compared with the LPS-induced or vehicle-treated ALI groups, the survival rate of the LPS-induced ALI mice was significantly improved following eriodictyol administration (Fig.…”