Protective Effect of Brazilian Propolis against Liver Damage with Cholestasis in Rats Treated with<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M1"><mml:mrow><mml:mi mathvariant="bold-italic">α</mml:mi></mml:mrow></mml:math>-Naphthylisothiocyanate

Nakamura, Tadashi; Ohta, Yoshiji; Ohashi, Koji; Ikeno, Kumiko; Watanabe, Rie; Tokunaga, Kenji; Harada, Nobuhiro

doi:10.1155/2013/302720

Cited by 14 publications

(22 citation statements)

References 57 publications

(93 reference statements)

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“…PP also contains various organic compounds such as phenols, tannins, polysaccharides, terpenes, aromatic acids, and aldehydes (Nakamura et al 2013). On the other hand, hyperammoniemia is accompanied with increased blood brain barrier permeability to the proinflammatory cytokines which induce the expression of iNOS.…”

Section: Discussionmentioning

confidence: 99%

“…PP also contains various organic compounds such as phenols, tannins, polysaccharides, terpenes, aromatic acids, and aldehydes (Nakamura et al 2013). The hepatoprotectivity of PP was previously explained by its potent inhibitory effects on CYP2E1, a CYP450 isoform that plays a major role in the metabolism of endogenous compounds as well as xenobiotics (Ryu et al 2016).…”

Section: Discussionmentioning

confidence: 99%

“…PP is characterized by its unique chemical constituents that target numerous biochemical and genetic pathways. The anti-inflammatory and oxyradical scavenging properties of PP attribute to its wide range of biological activities (Nakamura et al 2013). …”

Section: Introductionmentioning

confidence: 99%

“…This hepato-protection may be attributed to its several pharmacological actions due to its ability to inhibit lipid peroxidation (Nakamura et al 2013). However, it is still unclear whether PP exerts protective effects against hepatic encephalopathy in rats.…”

Section: Introductionmentioning

confidence: 99%

“…The anti-inflammatory and oxyradical scavenging properties of PP attribute to its wide range of biological activities (Nakamura et al 2013). Oral administration of PP and its main constituent was shown to be protective against acute liver damage induced by various hepatotoxicants such as carbon tetrachloride, alcohol, D-galactosamine and acetaminophen (Ramadan et al 2015;Seo et al 2003).This hepato-protection may be attributed to its several pharmacological actions due to its ability to inhibit lipid peroxidation (Nakamura et al 2013). However, it is still unclear whether PP exerts protective effects against hepatic encephalopathy in rats.…”

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confidence: 99%

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Hepato- and neuro-protective influences of biopropolis on thioacetamide-induced acute hepatic encephalopathy in rats

Mostafa

Salama

Abdel-Rahman

et al. 2017

Can. J. Physiol. Pharmacol.

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Hepatic encephalopathy (HE) is a neuropsychiatric syndrome ultimately occurs as a complication of acute or chronic liver failure; accompanied by hyperammonemia. This study aimed to evaluate the potential of biopropolis as a hepato and neuroprotective agent using thioacetamide (TAA)-induced acute HE in rats as a model. Sixty Wistar rats were divided into five groups: Group 1 (normal control) received only saline and paraffin oil.Group 2 (hepatotoxic control) received TAA (300 mg/kg, once). Groups 3, 4 and 5 received TAA followed by vitamin E (100 mg/kg) and biopropolis (100 and 200 mg/kg), respectively, daily for 30 days. Evidences of hepatic encephalopathy were clearly detected in TAA-hepatotoxic group including significant elevation in the serum level of ammonia, liver functions, increased oxidative stress in liver and brain, apoptotic DNA fragmentation and overexpression of iNOS gene in brain tissue. The findings for groups administered biopropolis, highlighted its efficacy as a hepato and neuro-protectant through improving the liver functions, oxidative status and DNA fragmentation as well as suppressing the brain expression of iNOS gene. In conclusion, bioproplois, at a dose of 200 mg/kg/day protected against TAA-induced HE through its antioxidant and antiapoptotic influence; therefore, it can be used as a protective natural product.Keywords: Biopropolis; hepatic encephalopathy; thioacetamide; iNOS; vitamin E. IntroductionHepatic encephalopathy (HE) is a neuropsychiatric syndrome resulting from acute or chronic liver failure (Lizardi-Cervera et al. 2003). HE affects a huge number of patients worldwide leading to a mortality rate of 50 to 90% (Raghavan and Marik 2006). HE causes a wide range of clinical manifestations, including psychomotor dysfunctions, sensory abnormalities, poor concentration, increased reaction time and impaired memory. Patients commonly develop stupor, coma and death in severe cases.The mechanism of HE has not been fully explained. However, hyper-ammonemia has been suggested to play the main role in HE pathogenesis and to be responsible for the direct and indirect alterations in cerebral metabolism and hence encephalopathy (Frederick 2011;Mustafa et al. 2013).Thioacetamide (TAA) is used to induce an experimental rat model mimicking acute hepatic failure and HE. This model has been validated to be a satisfactory model of HE (Avraham et al. 2006). TAA undergoes extensive metabolism to highly reactive metabolites that binds to liver macromolecules resulting in hepatic necrosis, hyperammonemia (Swapna et al. 2006) and extensive oxidative stress (Sathyasaikumar et al. 2007). Studies demonstrated that centrilobular necrosis is apparent after single dose of TAA, while cirrhosis, liver cell adenomas and liver cancer usually develop after chronic administration (Waters et al. 2005).Oxidative stress has long been involved in the pathogenesis of acute and chronic liver damage in many conditions such as toxin exposures, bile duct obstruction, excess alcoholism, liver ischemia, and viral inf...

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

mentioning

confidence: 99%

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Hepato- and neuro-protective influences of biopropolis on thioacetamide-induced acute hepatic encephalopathy in rats

Mostafa

Salama

Abdel-Rahman

et al. 2017

Can. J. Physiol. Pharmacol.

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Recent advances and opportunities related to the use of bee products in food processing

Kieliszek

Piwowarek

Kot

et al. 2023

Food Science & Nutrition

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One of the oldest examples of the existence of beekeeping is the murals from the Araña Cave in Spain, which show people collecting honey from the nest of untamed bees. In ancient times, honey was used as a medicine and also to embalm corpses. During Greek feasts, it was an indispensable part of the menu. However, the greatest boom in beekeeping took place in ancient Rome, where hives made of straw and clay were found, dating back to 900 B.C. (Kritsky, 2017). The Egyptians placed a vessel filled with a "golden drink" in the tombs of the pharaohs, which showed that it was indeed considered something special. In the beginning, people discovered that honey collected by bees can be found in the hollows of trees. They climbed these trees, taking the honey from the bees-the result of their hard work. Then, they started to breed bees, building their nests in the hollows of old trees, the so-called beehives. Shortly thereafter, they noticed that you can only relocate the part of the tree to the field where the hollow is located, and then you will not have to climb to ensure you have constant access to this valuable product. Over time, people, thinking

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Protective effects of propolis on hepatic steatosis and fibrosis among patients with nonalcoholic fatty liver disease (NAFLD) evaluated by real‐time two‐dimensional shear wave elastography: A randomized clinical trial

Soleimani

Rezaie

Rajabzadeh

et al. 2020

Phytotherapy Research

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Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease, while no drugs have been approved for its treatment. The pieces of evidence indicate that propolis as a novel anti-inflammatory agent might be a promising candidate to treat NAFLD. We aimed to evaluate the efficacy of propolis on hepatic steatosis and fibrosis in patients with NAFLD. This randomized clinical trial was conducted on 54 patients with NAFLD. Patients were randomly assigned to receive propolis tablets at a dose of 250 mg twice daily for 4 months or placebo. The improvement in hepatic steatosis and fibrosis was evaluated using two-dimensional shear wave elastography. Improvement in the hepatic steatosis was significantly higher in the propolis group than the placebo group, even after adjustment for baseline value and changes in weight, energy intake, and physical activity (odds ratio [OR]: 5.67; 95% confidence intervals [CI]: 1.41-22.8; p = .014). A significant reduction was observed on the liver stiffness in the propolis group (−0.65 ± 0.56 kPa; p = .001), whereas it increased in the placebo group (0.27 ± 0.59 kPa; p = .037). Also, the intake of propolis significantly decreased high-sensitivity C-reactive protein (hs-CRP) levels compared with the placebo group (−0.371; 95%CI: −0.582 to −0.16 mg/L; p = .01). Changes in serum levels of fasting blood sugar, alanine aminotransferase, aspartate aminotransferase,

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Protective Effect of Brazilian Propolis against Liver Damage with Cholestasis in Rats Treated withα-Naphthylisothiocyanate

Cited by 14 publications

References 57 publications

Hepato- and neuro-protective influences of biopropolis on thioacetamide-induced acute hepatic encephalopathy in rats

Hepato- and neuro-protective influences of biopropolis on thioacetamide-induced acute hepatic encephalopathy in rats

Recent advances and opportunities related to the use of bee products in food processing

Protective effects of propolis on hepatic steatosis and fibrosis among patients with nonalcoholic fatty liver disease (NAFLD) evaluated by real‐time two‐dimensional shear wave elastography: A randomized clinical trial

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