Protective effect of calpeptin on acrylamide-induced microtubule injury in sciatic nerve

Guan, Qiangdong; Su, Benyu; Wei, Xiaomin; Wang, Shue; Wang, Miaomiao; Liu, Ning; Jiang, Wenchong; Xu, Menglong; Sung, Yunsick

doi:10.1016/j.tox.2018.08.002

Cited by 14 publications

(7 citation statements)

References 42 publications

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“…In current experimental model, the validity of ACR-induced neurotoxicity was verified by two well defined evidences, i. e. decrease in body weight gain (Crofton et al, 1996;Lopachin et al, 2008;Ghareeb et al, 2010;Guano et al, 2018) and impairment of the cholinergic function, decrease in the activity of AChE (Antonio et al, 2003, Yousef andEl-Demerdash., 2006).…”

Section: Discussionmentioning

confidence: 77%

Contribution of Amyloid β-Peptides To Acrylamide-Induced Toxicity In Rat Brain Tissue

Özer¹,

Türkoğlu²

2019

Adv. Anim. Vet. Sci.

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Section: Discussionmentioning

confidence: 77%

Contribution of Amyloid β-Peptides To Acrylamide-Induced Toxicity In Rat Brain Tissue

Özer¹,

Türkoğlu²

2019

Adv. Anim. Vet. Sci.

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“…The doses of AA and allicin reagents were chosen according to the previous literature. 23,24 After 1 week of adaptation period, SD rats in the CON group were orally administered saline twice daily and two hours apart. The AA30 group was administrated with saline; the ALL25, ALL50, and ALLC50 groups were gavaged with allicin.…”

Section: ■ Materials and Methodsmentioning

confidence: 99%

“…Allicin was dissolved in saline to form stable emulsions of 25 and 50 mg/kg, respectively, which were then stored at 4 °C for later use. The doses of AA and allicin reagents were chosen according to the previous literature. , …”

Section: Methodsmentioning

confidence: 99%

Allicin Ameliorates Intestinal Barrier Damage via Microbiota-Regulated Short-Chain Fatty Acids-TLR4/MyD88/NF-κB Cascade Response in Acrylamide-Induced Rats

Yuan

Lü

Nan

et al. 2021

J. Agric. Food Chem.

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Acrylamide (AA) is a heat-induced toxicant, which can cause severe damage to health. In the present study, SD rats were used to investigate the potential therapeutic effects of allicin dietary supplementation in the rats with AA-induced intestinal injury. The elevated expression of occludin, claudin-1, zonula occludens-1 (ZO-1), mucin 2, and mucin 3 indicated that oral allicin alleviated the intestinal epithelial barrier breakage induced by AA, compared with the AA-treated group. In the gut microbiota, Bacteroides, Escherichia_Shigella, Dubosiella, and Alloprevotella related to the synthesis of short-chain fatty acids (SCFAs) were negatively affected by AA, while allicin regulated cascade response of the microbiota-SCFAs signaling to reverse the reduction of acetic acid and propionic acid by AA treatment. Allicin also dramatically down-regulated the expression of Toll-like receptor 4 (TLR4), myeloid differentiation factor 88 (MyD88), NF-κB signaling pathway proteins, and proinflammatory cytokines by promoting the production of SCFAs in AA-treated rats. Allicin relieved the intestinal barrier injury and inflammation caused by AA as evidenced by the regulation cascade response of the microbiota-SCFAs-TLR4/MyD88/NF-κB signaling pathway. In conclusion, allicin is highly effective in the treatment and prevention of AA-induced intestinal injury.

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“…Acrylamide (ACR) is widely used industrially, as in synthesis of the dyes and cosmetic manufacturing …”

Section: Introductionmentioning

confidence: 99%

Hypolipidemic and hepatoprotective synergistic effects of selenium nanoparticles and vitamin. E against acrylamide‐induced hepatic alterations in male albino mice

Hamza

Altalhi

Gobouri

et al. 2020

Applied Organom Chemis

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The potential benefit of selenium nanoparticles (SeNPs) and vitamin E (Vit.E) that they are potent antioxidants , they were used as antioxidants against acrylamide (ACR) hepatotoxicity, ACR is found in the starchy foods that had been heated for long periods in high degrees above 120°C. So the aim of the current study was to elucidate the antihyperlipidemic and hepatoprotective effects of either SeNPs and/or Vit.E against ACR toxicity, SeNPs were characterized by SEM, EDX, TEM and they proved their spherical nanostructure. Zeta potential value was –22.9 mv with particle size with a diameter range (48.75‐67.24 nm) which proved the high stability of the used SeNPs. Seven groups of male mice were used: group I was control,group II ACR,group III was treated with SeNPs, IV group was received Vit.E and groups V,VI received ACR plus SeNPs and ACR plus Vit.E, group VII was given combination of SeNPs and Vit.E plus ACR,So,The effect of SeNPs and/or Vit.E were monitored against ACR hepatotoxicity and hyperlipidemia. ACR administration afforded significant elevation in the hepatic enzymes with severe alterations in the lipid metabolism. These findings clarified the efficacy of SeNPs and Vit.E by declining the high hepatic enzymes activities induced by ACR along with improving the lipid profile, elevation of the antioxidant enzymes (SOD,CAT and GRx), reduction of MDA level, improving histological and ultrastructutral hepatic tissues and restoration of most normal structures that were damaged in ACR group. So, SeNPs and/or Vit.E were proved to enhance the hepatic antioxidant capacities.

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Protective effect of calpeptin on acrylamide-induced microtubule injury in sciatic nerve

Cited by 14 publications

References 42 publications

Contribution of Amyloid β-Peptides To Acrylamide-Induced Toxicity In Rat Brain Tissue

Contribution of Amyloid β-Peptides To Acrylamide-Induced Toxicity In Rat Brain Tissue

Allicin Ameliorates Intestinal Barrier Damage via Microbiota-Regulated Short-Chain Fatty Acids-TLR4/MyD88/NF-κB Cascade Response in Acrylamide-Induced Rats

Hypolipidemic and hepatoprotective synergistic effects of selenium nanoparticles and vitamin. E against acrylamide‐induced hepatic alterations in male albino mice

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