Protective effect of Canna indica on cerebral ischemia-reperfusion injury in rats

Talluri, Mallikarjuna Rao; Killari, K. N.; Manepalli, N.V.S. Viswanadha Murthy; Konduri, Prasad; Bandaru, Kiran Kumar

doi:10.1016/j.anres.2018.03.007

Cited by 4 publications

(2 citation statements)

References 43 publications

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“…It was proved by many researchers that natural antioxidants give promising results in stroke and related disorders. For example, hexahydrocurcumin, Canna indica, Danshen, quercetin, and vitamin E attenuate cerebral ischemic reperfusion injury in animals through antioxidants activity 44,45,46 .…”

Section: Discussionmentioning

confidence: 99%

Protective Effect of Ethanolic Extract From the Root of Argyreia Speciosa Against Global Cerebral Ischemic Reperfusion Injury in Rats

Jaiswal

Tailang

2018

J. Drug Delivery Ther.

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Cerebral stroke is the principal reason of death without effective treatment in the world and recognized as the common cause of disability. Argyreia speciosa (Linn.f.) (Convolvulaceae, Synonyms: Argyreia nervosa) is widely distributed plant species in India. It is commonly known as Elephant creeper and Vryddhadaru. A. speciosa is a very valuable plant in the Ayurvedic system. In 'Rasayan' drug it has been used for the treatment of various neurological diseases. Its root taste is bitter and having the multiple uses like as a brain tonic, nootropic, anti-anxiety and anticonvulsant activity. The current study, plan to investigate the neuroprotective effect of ethanolic extract of A. speciosa root (ASEE) in a validate rat model of stroke known as global cerebral ischemic reperfusion injury (GCIRI). We divided 36 male Wistar rats to six experimental groups (n= 6). The group-I considered as sham control (no GCIRI), Group-II saline treated GCIRI, Group-III, IV, and V received ASEE (100, 200 and 400 mg/kg, p.o.) for 7 days prior to the induction of GCIRI while Group-VI termed as standard and it received quercetin (20 mg/kg, i.p.) 30 min prior induction of GCIRI. GCIRI produced the significant neurological deficit, sensorimotor dysfunction, decrease neurobehavioral parameters, increased cerebral infarction area and brain edema as compared with sham control rats. Seven days of pretreatment with ASEE markedly attenuates all the changes caused by GCIRI to the normal level. Our results proved that ASEE possess the protective effect on GCIRI induced stroke and aforementioned neuroprotection may be due to its antioxidant and anti-inflammatory property. Keywords: Brain stroke, BCCAO, Antioxidants, Neuroprotection, Argyreia speciosa

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Section: Discussionmentioning

confidence: 99%

Protective Effect of Ethanolic Extract From the Root of Argyreia Speciosa Against Global Cerebral Ischemic Reperfusion Injury in Rats

Jaiswal

Tailang

2018

J. Drug Delivery Ther.

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“…Previous studies showed that the extract of edible canna root and rhizomes exhibited antinociceptive, anthelmintic (Nirmal et al 2007), antimicrobial (George 2014), antidiabetic, and antilipidemic activities (Subhash et al 2017). Edible canna demonstrated its ability to protect against oxidative-stress-induced ischemia in the rat (Talluri et al 2017). The anticancer activity of edible canna was studied in previous research.…”

Section: Introductionmentioning

confidence: 99%

Phytochemical analysis and cytotoxic activities of two distinct cultivars of Ganyong rhizomes (Canna indica) against the WiDr colon cancer cell line

et al. 2020

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Abstract. Ifandari, Widyarini S, Nugroho LH, Pratiwi R. 2020. Phytochemical analysis and cytotoxic activities of two distinct cultivars of Ganyong rhizomes (Canna indica) against the WiDr colon cancer cell line. Biodiversitas 21: 1660-1669. Canna indica L is an edible plant with high nutrient content and positive health benefits. In Indonesia, edible canna is divided into two cultivar groups: red edible canna and green edible canna. Canna indica L. is investigated in this study as a potential medicinal plant for colon cancer in WiDr cell lines. The phytochemical contents of two distinct cultivars of edible canna (known in Indonesia as ganyong), namely red edible canna and green edible canna. These two discrete samples were extracted by using two different solvents, dichloromethane and ethanol, followed by evaluation using Fourier-transform infrared (FTIR) spectroscopy in order to detected functional group. In the analysis of the composition of the elements of chemical compounds, the samples subsequently injected into the liquid chromatography−high-resolution mass spectrometry (LC-HRMS). The cell viability assay was performed to evaluate the cytotoxic activities of extracted compounds from two cultivars of edible canna in two different solvents. FTIR results demonstrated that the red and green edible canna extracts contained 17 and 18 functional group compounds, respectively. Furthermore, the cell viability was lower in WiDr cells treated with dichloromethane extract of red than green edible canna or the ethanol extract of red edible canna. Notably, LC-HRMS results of the most potent dichloromethane extract of red edible canna revealed the presence of fatty acid compounds. These findings indicate that the two cultivars of edible canna could potentially be utilized as promising candidates for colon cancer treatment.

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Evaluation of neuroprotective effects of Canna indica L against aluminium chloride induced memory impairment in rats

Ojha

Biradar

Tubachi

et al. 2022

ADV TRADIT MED (ADTM)

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Memory disorders are the progressive neurological disorder, mainly causing dementia, memory loss and cognitive dysfunctions. The current study is aimed to experimentally validate the crude extract of Canna indica aerial parts (CIA) and root (CIR) against aluminium chloride induced altered memory in rats. Initially, methanolic extract of CIA, hydroalcoholic extract of CIR, and their combination of CIA + CIR were screened for Invitro antioxidant activity via 2,2-diphenyl-1-picrylhydrazyl (DPPH) and nitric oxide (NO) assays, acetylcholinesterase (AChE) inhibitory assay and were also screened for their memory enhancing activity by in-vivo models such as elevated plus maze (EPM), morris water maze (MWM), cooks pole climb (CPC), Actophotometer, novel object recognition (NOR), and T-maze. Aluminium chloride (AlCl 3 ) (17 mg/kg/day p.o.) for 21 days, was used as an Alzheimer's disease inducing agent and Donepezil (AChE inhibitor) as a standard treatment agent. The AChE, butyrylcholinesterase (BChE) activity and malondialdehyde (MDA) level were significantly increased, and glutathione (GSH), total protein (TP), catalase (CAT), and Dopamine were decreased only in AlCl 3 treated rats and treatment with CIA 200 mg/kg and CIA + CIR 200 mg/kg significantly reversed these mechanisms.Histopathology of cortex and hippocampus was examined at 40× magnification, indicating maintain of integrity and architecture of CA1 and CA3 neuronal cells compared to control and standard groups. The in vivo studies of interospective and exteroceptive behavior models (EPM), MWM, CPC, Actophotometer, NOR, T-maze revealed that AlCl 3 administration enhanced transfer latency (TL), escape latency time (ELT) and decreases locomotion, discriminatory index, and percentage alternation respectively. However, treatment with CIA and CIA + CIR 200 mg/kg highly significantly reversed the pathological changes of disease, extracts of Canna indica of both root and aerial parts phyto constituents are rich in flavonoids, phlobatannins, anthocyanin pigments, saponins, alkaloids, steroids, terpenoids etc. Which will decipher the acetylcholinestrase inhibitory, antioxidant and antiinflammatory activity, will ameliorate the pathological state of Alzheimer disease.

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Protective effect of Canna indica on cerebral ischemia-reperfusion injury in rats

Cited by 4 publications

References 43 publications

Protective Effect of Ethanolic Extract From the Root of Argyreia Speciosa Against Global Cerebral Ischemic Reperfusion Injury in Rats

Protective Effect of Ethanolic Extract From the Root of Argyreia Speciosa Against Global Cerebral Ischemic Reperfusion Injury in Rats

Phytochemical analysis and cytotoxic activities of two distinct cultivars of Ganyong rhizomes (Canna indica) against the WiDr colon cancer cell line

Evaluation of neuroprotective effects of Canna indica L against aluminium chloride induced memory impairment in rats

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