2016
DOI: 10.3892/mmr.2016.5513
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Protective effect of cannabidiol on hydrogen peroxide-induced apoptosis, inflammation and oxidative stress in nucleus pulposus cells

Abstract: Cannabidiol, a major component of marijuana, protects nerves, and exerts antispasmodic, anti-inflammatory and anti‑anxiety effects. In the current study, the protective effect of cannabidiol was observed to prevent hydrogen peroxide (H2O2)‑induced apoptosis, inflammation and oxidative stress in nucleus pulposus cells. Nucleus pulposus cells were isolated from rats and cultured in vitro, and H2O2 was used to construct the nucleus pulposus cell model. Cell viability of the nucleus pulposus cells was assessed usi… Show more

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Cited by 42 publications
(38 citation statements)
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“…The neuroprotective effects of CBD are the subject of many current research studies and are mediated via antiapoptosis, anti‐inflammation, and antioxidative activities, as well as by protecting mitochondrial function . We have recently documented that CBD treatment not only prevents reinstatement of METH seeking in control animals but also inhibits METH‐induced reinstatement in the RSD rats .…”
Section: Discussionmentioning
confidence: 99%
“…The neuroprotective effects of CBD are the subject of many current research studies and are mediated via antiapoptosis, anti‐inflammation, and antioxidative activities, as well as by protecting mitochondrial function . We have recently documented that CBD treatment not only prevents reinstatement of METH seeking in control animals but also inhibits METH‐induced reinstatement in the RSD rats .…”
Section: Discussionmentioning
confidence: 99%
“…Although numerous studies have investigated apoptosis, few studies have examined how oxidative stress results in nucleus pulposus cell apoptosis and intervertebral disc degeneration (10,13,14). Therefore, the current study used H 2 O 2 to establish an oxidative stress model in nucleus pulposus cells in order to identify the underlying mechanisms (15).…”
Section: Discussionmentioning
confidence: 99%
“…When these defense mechanisms cannot prevent the generation of excessive reactive oxygen species, oxidative stress will occur, which causes the degeneration of cells or protein tissue, lipid oxidation, DNA damage and other physiological dysfunctional processes, leading to apoptosis (7). However, only a limited number of studies have focused on intervertebral disc degeneration and the apoptosis of nucleus pulposus cells due to oxidative stress (8)(9)(10).…”
Section: Introductionmentioning
confidence: 99%
“…Since the oxidative stress induced in HUVECs by H 2 O 2 is a useful and sensitive model of this condition, it has been widely used to assess cardiovascular oxidative damage in vitro (Chen et al, ; Kaczara, Sarna, & Burke, ; Sohel et al, ; Wijeratne, Cuppett, & Schlegel, ). The development of oxidative stress in an organism and cell involves complex molecular mechanisms.…”
Section: Introductionmentioning
confidence: 99%