Protective effect of carbon dots derived from scrambled Coptidis Rhizoma against ulcerative colitis in mice

Mou, Yanfang; Bai, Xue; Ma, Huagen; Li, Tingjie; Zhao, Yafang; Wu, Tong; Zhang, Yue; Qu, Huihua; Kong, Hui; Wang, Xueqian; Zhao, Yan

doi:10.3389/fmolb.2023.1253195

Cited by 3 publications

(1 citation statement)

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“…After it had cooled down naturally, it was subsequently pulverized into a fine powder. The resulting black powder was then dispersed in deionized water and subjected to two rounds of boiling in a water bath, each lasting for 1 h ( Luo et al, 2021 ; Mou et al, 2023 ). Larger products were removed using a 0.22 μm microporous membrane.…”

Section: Methodsmentioning

confidence: 99%

Aurantii fructus immaturus carbonisata-derived carbon dots and their anti-depression effect

Li,

Dai,

et al. 2024

Front. Mol. Biosci.

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Introduction: Depression is a common illness worldwide. However, the current treatments available for depression only achieve relative success, often come with several side effects, and are associated with high costs. Aurantii Fructus Immaturus (AFI) has a rich historical legacy in Traditional Chinese Medicine (TCM) for its traditional use as a treatment for depression. In this research, our primary objective is to examine the potential antidepressant properties and the mechanisms at play behind a particular bioactive compound found in AFI, which is referred to as carbon dots derived from AFI Carbonisata (AFIC-CDs).Methods: Extracted and isolated the AFIC-CDs from the decoction of AFIC, then characterized the morphological structure and functional groups comprehensively. We then utilized two distinct models to investigate the anti-depressive properties of AFIC-CDs: the chronic unpredictable mild stress (CUMS) model and the reserpine-induced pain-depression dyad model. In the CUMS model, we assessed immobile time and measured neurotransmitter levels in the mouse brain cortex. In the pain-depression dyad model, we evaluated immobile time, neurotransmitter levels, interleukin-1 (IL-1β) and tumor necrosis factor-α (TNF-α) levels, and the expression of mRNA of brain-derived neurotrophic factor (BDNF) and tryptophan hydroxylase 2 (Tph2).Results: AFIC-CDs were found to have abundant chemical groups, and their diameter ranged from 2 to 10 nm. In the CUMS model, AFIC-CDs demonstrated significant effects. They reduced the immobile time of the mice and increased the levels of serotonin (5-HT), dopamine (DA), and norepinephrine (NE) in the mouse brain cortex. In the pain-depression dyad model, the AFIC-CDs groups decreased the immobile time, showed effect in increasing both the neurotransmitters’ levels and the expression of mRNA of BDNF and Tph2, and decreased the IL-1β and TNF-α levels in mouse brain cortex. Taken together, these results strongly indicate that AFIC-CDs possess significant antidepressant activity.Conclusion: AFIC-CDs demonstrate promising therapeutic potential in the treatment of depression, suggesting that they may become a valuable candidate for depression management. This not only extends the understanding of the biological activity of carbon dots (CDs) but also opens up new possibilities for the development of effective depression treatment strategies.

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Section: Methodsmentioning

confidence: 99%

Aurantii fructus immaturus carbonisata-derived carbon dots and their anti-depression effect

Li,

Dai,

et al. 2024

Front. Mol. Biosci.

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Protective effect of carbon dots as antioxidants on intestinal inflammation by regulating oxidative stress and gut microbiota in nematodes and mouse models

Peng,

Wang,

Zhu

et al. 2024

International Immunopharmacology

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Hemostatic bioactivity and mechanism of novel Rubia cordifolia L.-derived carbon dots

Zhang,

Hu,

et al. 2024

Nanoscale Adv.

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Protective effect of carbon dots derived from scrambled Coptidis Rhizoma against ulcerative colitis in mice

Abstract: Graphical AbstractSchematic diagram of the synthesis of SCR-CDs and diagram of the experimental protocol.

Cited by 3 publications

References 63 publications

Aurantii fructus immaturus carbonisata-derived carbon dots and their anti-depression effect

Aurantii fructus immaturus carbonisata-derived carbon dots and their anti-depression effect

Protective effect of carbon dots as antioxidants on intestinal inflammation by regulating oxidative stress and gut microbiota in nematodes and mouse models

Hemostatic bioactivity and mechanism of novel Rubia cordifolia L.-derived carbon dots

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