Protective Effect of CCR5 Delta-32 Allele Against HIV-1 in Mexican Women

Abstract

C-C chemokine receptor type 5 (CCR5) is known for its role as a co-receptor for HIV-1 infection. Some individuals possess a 32 bp deletion, known as Delta-32 allele which has been reported to confer resistance to HIV-1 infection. In order to estimate the distribution of Delta-32 allele of CCR5 gene, 1034 mestizo individuals from the Northwest of Mexico, including 385 HIV-1-infected individuals, 472 healthy controls and 177 uninfected female sex workers; were examined by allele-specific PCR. There was no statistically significant difference in the frequency of Delta-32 allele between HIV-1 positive and healthy individuals (OR= 1.1, p= 0.6). However, we found a significantly reduced prevalence of CCR5 Delta-32 heterozygous genotype in female patients (OR= 0.084, 95% CI= 0.011 - 0.630, p= 0.002), as well as in allele frequency, compared to male patients. Furthermore, we observed an inverse relationship between allele frequency and the risk of HIV-1 transmission and AIDS progression among female healthy controls, sex workers and HIV-1 infected groups. Our findings support previous data showing Delta-32 as a genetic protective factor against HIV-1 infection in Mexican women, as well as in women from other populations.

Occurrence of CCR5 Heterozygous 32 bp Deletion in Nepali Ethnic Groups

“…Some results in Slovakian populations do not indicate that a relatively low incidence of HIV-1 infection in Slovakia could be caused by the CCR5-Δ32 mutation (Takacova et al 2008). Some findings support previous data showing Delta-32 as a genetic protective factor against HIV-1 infection in Mexican women, as well as in women from other populations (Estrada-Aguirre et al 2013). Recently a positive correlation has been established between CCR5-Δ32 and lupus nephritis risk in the Chinese Han ethnic population by playing a role in lupus nephritis susceptibility (Cheng et al 2014).…”

Correlation of Apolipoprotein B mRNA-editing Enzyme, Catalytic Polypeptide- like 3G Genetic Variant rs8177832 with HIV-1 Predisposition in Pakistani Population

“…Now it has been cleared that individuals with homozygous Δ32 allelic variants of the CCR5 protein are strongly, although not completely resistant to HIV infection. Truncated CCR5 does not act as a co-receptor for binding of HIV virion with the host cell, hence providing protection against HIV infection [15, 16]. Moreover, the ethnic differences also participate in host predisposition or protection against viral infection [17-19].…”

Thyroid cancer in a long-term nonprogressor HIV-1 infection

“…[9] Usually, individuals with homozygous delta 32 allele are resistant to HIV infection in spite of multiple exposures to HIV-infected persons while those with heterozygous delta 32 mutation have lesser viral replication and slower progression of HIV infection. [10] We have not evaluated our patient for molecular markers. Until date, patient has got good quality life following total thyroidectomy.…”