Protective Effect of Ceftriaxone against the Nephrotoxicity of Isepamicin Administered Once Daily in Rats.

Yoshiyama, Yuji; Yazaki, Tomoko; Beauchamp, Denis; Kanke, Motoko

doi:10.1248/bpb.21.520

Cited by 11 publications

(7 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Other non-antibiotic actions of CTX on animal studies demonstrated that it could ameliorate morphine tolerance (Rawls et al 2010b), and dependence (Rawls et al 2010a), diabetic hyperalgesia (Gunduz et al 2011) and neuropathic pain (Liu et al 2010). Moreover, CTX attenuate cyclosporine A (Yilmaz et al 2011), tobramycin (Beauchamp et al 1994), isepamicin (Yoshiyama et al 1998), and cadmiuminduced (Dwivedi et al 2012) nephrotoxicity in rats.…”

Section: Introductionmentioning

confidence: 99%

Synergistic protective role of ceftriaxone and ascorbic acid against subacute diazinon-induced nephrotoxicity in rats

Abdel-Daim

2014

Cytotechnology

View full text Add to dashboard Cite

Diazinon (DZN) is a synthetic organophosphrus acaricide and insecticide widely used for veterinary and agricultural purposes. However, its animal and human exposure leads to nephrotoxicity. Our experimental objective was to evaluate protective effects of ceftriaxone and/or ascorbic acid-vitamin C against DZN-induced renal injury in male Wistar albino rats. DZN-treated animals revealed significant elevation in serum biochemical parameters related to renal injury: urea, uric acid and creatinine. DZN intoxication significantly increased renal lipid peroxidation, and significant inhibition in antioxidant biomarkers including, reduced glutathione, glutathione peroxidase, superoxide dismutase, catalase and total antioxidant capacity. In addition, DZN significantly reduced serum acetylcholinestrase level. Moreover, It induced serum and kidney tumor necrosis factor-a level. Both ceftriaxone and vitamin C protect against DZN-induced serum as well as renal tissue biochemical parameters when used alone or in combination along with DZN-intoxication. Furthermore, both ceftriaxone and vitamin C produced synergetic nephroprotective and antioxidant effects. Therefore, it could be concluded that ceftriaxone and/or vitamin C administration are able to minimize the toxic effects of DZN by its free radical-scavenging and potent antioxidant activity.

show abstract

Section: Introductionmentioning

confidence: 99%

Synergistic protective role of ceftriaxone and ascorbic acid against subacute diazinon-induced nephrotoxicity in rats

Abdel-Daim

2014

Cytotechnology

View full text Add to dashboard Cite

show abstract

“…[15][16][17] In this study, we investigated the effect of 6-day coadministration of FOM on nedaplatin-induced nephrotoxicity in rats. The study showed that FOM protected against nedaplatin-induced nephrotoxicity, as shown by lower urinary excretion of NAG and lower BUN and serum creatinine levels, as well as fewer histopathological signs of nephrotoxicity in the groups treated with the nedaplatin ϩ FOM combination as compared the group treated with nedaplatin alone.…”

Section: Discussionmentioning

confidence: 99%

The effect of fosfomycin on nedaplatin-induced nephrotoxicity in rats

Yoshiyama

Yamaguchi

Matsuo

et al. 2005

Journal of Infection and Chemotherapy

Self Cite

View full text Add to dashboard Cite

“…Other non-antibiotic pharmacodynamic effects of CTX on animal studies demonstrated that it could reduce morphine tolerance and dependence 13 , ameliorate diabetic hyperalgesia 14 , and diminish neuropathic pain 15 . Moreover, CTX attenuated nephrotoxicity in rats induced by cadmium 16 , cyclosporine A 17 , tobramycin 18 , and isepamicin 19 .…”

Section: Introductionmentioning

confidence: 95%

Synergistic protective effects of ceftriaxone and ascorbic acid against subacute deltamethrin-induced nephrotoxicity in rats

Abdel-Daim

El-Ghoneimy

2014

Renal Failure

View full text Add to dashboard Cite

Deltamethrin (DLM) is a synthetic class II pyrethroid acaricide and insecticide widely used for veterinary and agricultural purposes. However, its animal and human exposure leads to nephrotoxicity. Our experimental objective was to evaluate protective effects of ceftriaxone and/or ascorbic acid against DLM-induced renal injury in male Wistar albino rats. DLM-treated animals revealed significant alterations in serum biochemical parameters related to renal injury; urea, uric acid and creatinine. There was a significant increase in renal lipid peroxidation and a significant inhibition in antioxidant biomarkers. Moreover, DLM significantly reduced serum acetylcholinesterase (AChE) activity. In addition, It induced serum and kidney tumor necrosis factor-α (TNF-α). Both ceftriaxone and ascorbic acid protect against DLM-induced biochemical alterations in serum and renal tissue when used alone or in combination along with DLM-intoxication. Furthermore, both ceftriaxone and ascorbic acid produced synergetic nephroprotective and antioxidant effects. Therefore, it could be concluded that ceftriaxone and/or ascorbic acid administration able to minimize the toxic effects of DLM through their free radical-scavenging and potent antioxidant activity.

show abstract

Protective Effect of Ceftriaxone against the Nephrotoxicity of Isepamicin Administered Once Daily in Rats.

Cited by 11 publications

References 0 publications

Synergistic protective role of ceftriaxone and ascorbic acid against subacute diazinon-induced nephrotoxicity in rats

Synergistic protective role of ceftriaxone and ascorbic acid against subacute diazinon-induced nephrotoxicity in rats

The effect of fosfomycin on nedaplatin-induced nephrotoxicity in rats

Synergistic protective effects of ceftriaxone and ascorbic acid against subacute deltamethrin-induced nephrotoxicity in rats

Contact Info

Product

Resources

About