Protective Effect of Continuous Retrograde Cerebral Perfusion on the Brain During Deep Hypothermic Systemic Circulatory Arrest

Abstract

Deep hypothermic circulatory arrest has been widely used as an adjunct for surgery of the aortic arch to protect the brain and other vital organs. We introduced the use of continuous retrograde cerebral perfusion via the superior vena cava during deep hypothermic circulatory arrest in 1987 and have used it in 33 patients. Continuous retrograde cerebral perfusion times ranged from 10 to 89 minutes (mean 40.2 +/- 22.5), and minimal nasopharyngeal temperatures ranged from 14 to 25 degrees C (mean 17.4 +/- 2.0). Two patients with a ruptured aneurysm died during operation due to bleeding and two other patients, with continuous retrograde cerebral perfusion time of 24 and 35 minutes, died 1 month postoperatively due to preoperative liver cirrhosis and sepsis. Two patients suffered from stroke. The remaining 27 patients, including 6 with from 60 to 82 minutes of continuous retrograde cerebral perfusion, had no complications related to continuous retrograde perfusion. During continuous retrograde cerebral perfusion, 66 pairs of blood samples from the perfusate and from the drainage back to the arch vessels were obtained. Analysis of these samples revealed that partial pressure of oxygen, saturation of oxygen, and oxygen content significantly decreased (p < 0.001), and partial pressure of carbon dioxide (CO2) and CO2 content significantly increased (p < 0.001). The nasopharyngeal temperature gradually increased at the rate of 0.01 to 0.03 degree C/min, but was maintained below 20 degrees C. These results reflect the fact that the aerobic metabolism of the brain is maintained during continuous retrograde cerebral perfusion due to oxygen and substrate availability. This technique offers the potential of metabolic support to the brain during deep hypothermic circulatory arrest and prolongs the safe time limits of deep hypothermic circulatory arrest in surgery of the aortic arch.

The effect of FR167653 on cerebral ischemia-reperfusion injury after retrograde cerebral perfusion in a canine model

“…Although dogs are not precisely suitable as the experimental model :for RCP because of the small internal jugular vein with many venous valves [7], in this experimental study, blood infusion for RCP was performed directly into the temporal sinus bilaterally via the internal maxillary veins with no venous valves. It is unclear whether aerobic metabolism proceeds as a result of the oxygen provided to the brain during RCP, however, RCP may wash out the accumulated metabolite and can maintain brain temperature at an optimal level during RCP as a result of the cold blood perfusate being infused [8].…”

Retrograde cerebral perfusion: clinical and experimental aspects

“…The effluent blood is desaturated, suggesting cerebral oxygen extraction. 44,57 In our own studies of carotid artery effluent during RCP, we have found significant transcranial glucose and oxygen extraction (mean 1 µmol/l and 22 ml/ml, respectively). However, the low effluent pO 2 (mean 14 mmHg), and high glucose extraction suggest ongoing cerebral ischaemia (unpublished observations).…”

Aortic reconstruction with bovine pericardial grafts

“…Other developments such as the use of deep hypothermia, the utilization of total circulatory arrest and more efficient methods for myocardial and cerebral protection, improved the immediate and long-term results of the surgical procedure of these frequently challenging afflictions [8,9]. Among these developments is the use of man-made materials of synthetic fibers, which are making the aortic aneurysmal segment replacement the procedure of choice for this disease [10,11].…”