Protective Effect of Corni fructus Ethanol Extracts Against Environmental Hormones in Human Prostate Cancer Cells

Abstract

Anti-proliferation effects of Corni fructus ethanol extracts were investigated in the RC58T/h/SA#4 cells treated with environmental hormones including dioxin and bisphenol A. The proliferation was decreased at the concentration over 500 μg/mL in the RC58T/h/SA#4 cells with ethanol extracts of various concentrations (1, 10, 100, 500, and 1000 μg/mL). The environmental hormones such as dioxin and bisphenol A increased the growth of RC58T/h/SA#4 cells in the charcoal-treated FBS (cFBS) medium. The proliferation was the highest at 1 nM and 0.1 μM for the tested dioxin and bisphenol A concentration, respectively. Ethanol extracts showed inhibition of the proliferation in a dose-dependent manner at the tested concentrations (10, 100, 300, and 500 μg/mL) in the RC58T/h/SA#4 cells treated with the environmental hormones. The anti-proliferation was the highest at 500 μg/mL concentration among the tested ethanol extracts.