Protective effect of curcumin against seizures and cognitive impairment in a pentylenetetrazole-kindled epileptic rat model

Mehla, Jogender; Reeta, K.H.; Gupta, Pooja; Gupta, Yogendra Kumar

doi:10.1016/j.lfs.2010.09.006

Cited by 154 publications

(109 citation statements)

References 55 publications

(54 reference statements)

Supporting

Mentioning

102

Contrasting

Order By: Relevance

“…Recent preclinical studies demonstrated that curcumin may exhibit promising anticonvulsant effect [10,11] as well as potential antiepileptogenic effect [12,13] . It also has been shown to possess protective effects in ameliorating cognitive impairments and anxiety in epileptic animals [11,13,14] . These benefits highlighted curcumin as a potential antiepileptic agent for clinical management.…”

Section: Research Papermentioning

confidence: 99%

The Effect of Curcumin on Anxiety and Recognition Memory in Kainate Model of Epileptic Rats

Yow

Ahmad²,

Azmi³

et al. 2017

Journal of Pharmaceutical Sciences

View full text Add to dashboard Cite

Yow, et al.: Anxiety and Recognition Memory Alteration by CurcuminThe effect of curcumin had been studied on anxiety and recognition memory in kainic acid-induced epilepsy. A single dose of intraperitoneal kainic acid (10 mg/kg) was used to induce status epilepticus in female Wistar rats, followed by respective treatments (vehicle dimethyl sulfoxide 50%, curcumin 100 mg/kg/d or levetiracetam 100 mg/kg/d) on the next day for 7 d, with minimum of six rats per group. The behavioural tests were performed before seizure induction and after treatment. Vehicle-treated epileptic rats showed an increase in anxiety-like behaviours in the open field test, which less observed in the light/dark box test. Levetiracetam-treated epileptic rats exhibited anxiolytic behaviours in both the tests. Curcumin-treated epileptic rats exhibited not much difference in anxiety-like behaviour before and after the treatment in open field test, but exhibited anxiolytic behaviours in light/dark box test. Kainic acid impaired the both spatial and non-spatial recognition memories of the rats. Curcumin treatment showed reversal in the non-spatial recognition impaired by kainic acid. In conclusion, kainic acid increases anxiety-like behaviours and impaired recognition memories during the early phase of epileptogenesis and curcumin was potentially improved anxiety and non-spatial recognition memory impaired by kainic acid. These benefits highlighted the potential effect of curcumin to improve psychiatric disorders in epilepsy.

show abstract

Section: Research Papermentioning

confidence: 99%

The Effect of Curcumin on Anxiety and Recognition Memory in Kainate Model of Epileptic Rats

Yow

Ahmad²,

Azmi³

et al. 2017

Journal of Pharmaceutical Sciences

View full text Add to dashboard Cite

show abstract

“…An early and persistent deficit of spatial memory during epileptogenesis was demonstrated in pilocarpine model of temporal lobe epilepsy (14)(15)(16). Further, pentylenetetrazol kindled seizures produced a profound decrease in learning and memory of rat in Morris water maze test (17,18). However, kainatetreated rats revealed less impaired spatial memory (19).…”

Section: Introductionmentioning

confidence: 99%

Reversal Effect of Coriandrum sativum Leaves Extract on Learning and Memory Deficits Induced by Epilepsy in Male Rat

Elahdadi-Salmani

Khorshidi

Ozbaki

2015

Zahedan J Res Med Sci

View full text Add to dashboard Cite

Background:The extract of Coriandrum Sativum L., commonly known as coriander, belonging to the Apiaceae family (Umbelliferae), is cultivated throughout the world for its nutritional value. C. sativum was shown to enhance cognitive performance and recover memory deficit. On the other hand, epilepsy induces cognitive disorders; learning and memory deficits in different animal models. Thus, the present study was undertaken to investigate the effects of C. sativum on water maze learning and memory of epileptic rats. Materials and Methods:In this experimental study, C. sativum extract was injected intraperitoneally for 7 consecutive days to experimental animals. Pilocarpine was administered (i.p.) to induce epileptic convulsions. Morris water maze (MWM) apparatus served as the behavioral model for testing spatial learning and memory. Latency to locate the platform, swimming distance and velocity were employed as variables in acquisition and probe trials, while crossing and proximity were only used in probe test. Results: The latency and distance to reach the hidden platform increased in pilocarpine treated rats. C. sativum extract decreased the latency and distance to platform compared with control and more prominently compared with epileptic group. Pilocarpine convulsions increased the platform location latency, but C. sativum extract did not reverse this seizure induced latency increase. Conversely, C. sativum extract reversed the seizure induced proximity increase. Conclusion: C. sativum extract may be a useful remedy in the management of epilepsy induced learning and memory impairments.

show abstract

“…Recent preclinical studies demonstrated that curcumin may exhibit promising anticonvulsant effect, 8 as well as potential antiepileptogenic effect. 9,10 It also has been shown to possess protective effects in ameliorating cognitive impairments and anxiety in epileptic animals. 9,11 These benefits highlighted curcumin as a potential antiepileptogenic agent for controlling the epilepsy and psychiatric-related comorbidities.…”

Section: Introductionmentioning

confidence: 99%

“…9,10 It also has been shown to possess protective effects in ameliorating cognitive impairments and anxiety in epileptic animals. 9,11 These benefits highlighted curcumin as a potential antiepileptogenic agent for controlling the epilepsy and psychiatric-related comorbidities. Nevertheless, the molecular mechanisms of curcumin that modulate the epileptogenesis are poorly understood.…”

Section: Introductionmentioning

confidence: 99%

Curcumin: The Molecular Mechanisms of Action in Inflammation and Cell Death during Kainate-Induced Epileptogenesis

Yow¹,

Ahmad²,

Azmi³

et al. 2018

IJPER

View full text Add to dashboard Cite

Background: Recent preclinical studies demonstrated the potential antiepileptogenic effect of curcumin. Its molecular pathways in modulating epileptogenesis remain unclear. Objectives: This study investigated the epileptogenic processes induced by kainic acid (KA) and to investigate the antiepileptogenic pathways associated with curcumin therapy. Methods: A single dose of KA 10 mg/kg was used to induce a convulsive status epilepticus in female Wistar rats. After one week of curcumin treatment, gene expression profiling by using microarray was conducted on hippocampal tissues. A set of differential expression changes was determined based on criteria of dual fold change in either direction and p < 0.05, whereas gene annotation and pathway analysis had been performed using Database for Annotation, Visualization and Integrated Discovery software. Results: A number of genes significantly altered in expression during KAinduced epileptogenesis. Inflammation and immune response were the prominent overexpressed processes induced by KA. Genes of cell surface molecule (CD74), cytokines and immune response related genes (IL18, IFNGR1, C3, RT1-BA) were significantly up-regulated. Changes of genes related to cell death and gliosis (NCSTN, CTSH) were also observed in KA-induced epileptogenesis. This study revealed that curcumin modulated the epileptogenic process by up-regulating genes related to antiinflammatory cytokines (IL10RB, CXCL16, and CXCL17) and protecting against cell loss by up-regulating NCSTN. It was also likely to exert neuroprotective effects through the up-regulation of CX3CL1 and CXCL16. Conclusion: This study provides novel insights into the mechanisms of curcumin in epileptic brain, which form the basis for future studies looking into its molecular pathway as an antiepileptogenic agent.

show abstract

Protective effect of curcumin against seizures and cognitive impairment in a pentylenetetrazole-kindled epileptic rat model

Cited by 154 publications

References 55 publications

The Effect of Curcumin on Anxiety and Recognition Memory in Kainate Model of Epileptic Rats

The Effect of Curcumin on Anxiety and Recognition Memory in Kainate Model of Epileptic Rats

Reversal Effect of Coriandrum sativum Leaves Extract on Learning and Memory Deficits Induced by Epilepsy in Male Rat

Curcumin: The Molecular Mechanisms of Action in Inflammation and Cell Death during Kainate-Induced Epileptogenesis

Contact Info

Product

Resources

About