Protective Effect of Curcumin versus N-acetylcystein on Acetaminophen Induced Hepatotoxicity in Adult Albino Rats

AB, Naglaa; HE, Saad

doi:10.4172/2157-7099.s3-018

Cited by 5 publications

(1 citation statement)

References 46 publications

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“…-Group (II) or curcumin group, in which each rat received curcumin dissolved in corn oil (100 mg /kg /day) [9,10] .…”

Section: Experimental Designmentioning

confidence: 99%

Does curcumin protect against hazards of aspartame intake on the cerebellar cortex of male adult albino rats? Histological and immunohistochemical study

Ibrahim

2019

Journal of Medical Histology

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Background: Aspartame is an artificial sweetener and unfortunately its intake might cause a dangerous effect on the cerebellar cortex. Curcumin has a neuroprotective role in many diseases. Objective: The study aimed to assess the possible ameliorating role of curcumin against the structural changes of cerebellar cortex that had been associated with aspartame administration in adult wistar rats. Materials and Methods: 48 male adult wistar rats were divided equally into 4 groups. Group I or control, group II or curcumin group each rat received curcumin 100mg/kg/day, group III, each rat received aspartame 250 mg/kg/day and in group IV, each rat received curcumin and aspartame as group II and group III concomitantly. The doses were given orally once daily for 8 weeks. By the end of the experiment, all animals were sacrificed, specimens of cerebellum were processed and stained with hematoxylin and eosin, Glial Fibrillary Acidic Protein (GFAP) and caspase-3 for histological and immunohistochemical studies. Morphometric and statistical studies were performed. Results: Cerebellar cortex of aspartametreated group showed features of neurodegeneration of purkinje cells with areas of neuropil loss in the molecular and granular layers. Also, area percentage of GFAP immunoexpression was increased. The number of purkinje cells that showed positive immunoreaction of caspase 3 was also increased. On concomitant administration of curcuminwith aspartame, the structural changes of cerebellar cortex were decreased. Conclusion: Curcumin intake partially protects the cerebellar cortex from hazards of aspartame intake ,so supplementation of curcuminin diet is recommended with regular intake of aspartame.

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“…-Group (II) or curcumin group, in which each rat received curcumin dissolved in corn oil (100 mg /kg /day) [9,10] .…”

Section: Experimental Designmentioning

confidence: 99%

Does curcumin protect against hazards of aspartame intake on the cerebellar cortex of male adult albino rats? Histological and immunohistochemical study

Ibrahim

2019

Journal of Medical Histology

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Effect of Potassium Bromate on the Liver of Adult Male Albino Rat and A Possible Protective Role of Vitamin C: Histological, Immunohistochemical, and Biochemical Study

Bayomy

Soliman

Abdelaziz

2016

The Anatomical Record

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Potassium bromate (KBrO 3 ) is a food additive which is used primarily as a maturing agent for flour. It is proved as a toxic agent with significant reduction in the activities of antioxidant capacity. The therapeutic efficacy of vitamin C as antioxidant may provide a possible solution to KBrO 3 mediated oxidative damage. Twenty four adult male albino rats were used to evaluate the protective role of vitamin C against KBrO 3 induced hepatotoxicity and divided into four groups; Group 1 (control), Group 2: received 30 mg/Kg/day vitamin C orally for 4 weeks, Group 3: received 20 mg/Kg/dose KBrO 3 orally twice weekly for 4 weeks and Group 4: received both KBrO 3 and vitamin C. Liver specimens were processed for histological study by light and electron microscopes and stained immunohistochemically to detect glial fibriller acidic protein (GFAP). Serum levels of aspartate aminotransferase (AST) and alanine aminotransferase (ALT) were estimated as well as the levels of malondialdehyde (MDA), glutathione (GSH) and superoxide dismutase (SOD) activities in all dissected tissues were determined. KBrO 3 induced histological alterations in the form of degeneration, cellular infiltration and significant increase in collagen deposition in portal tracts with a significant increase in immunoexpression of GFAP. Significant rise in serum levels of AST, ALT, and MDA in liver tissues were recorded. However, levels of GSH and SOD were significantly decreased. Most of these changes were improved by vitamin C treatment. In conclusion, vitamin C ameliorates the histological and biochemical alterations of the liver induced by KBrO 3 .

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Curcumin ameliorated low dose-Bisphenol A induced gastric toxicity in adult albino rats

Ismail

El-Meligy

2022

Sci Rep

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Bisphenol A (BPA) is one of the most common worldwide chemicals involved in the industry of polycarbonate plastics, medical devices, and pharmaceuticals. Forty three-month-old albino rats were randomly classified into four groups. Group Ӏ received a daily corn oil dose (5 mL/kg/ body weight, BW) through a gastric tube for one month, Group ӀӀ received a daily dose of Curcumin (200 mg/kg body weight (B.W.) through a gastric tube for one month, Group ӀӀӀ received a daily dose of BPA (0.5 μg/kg B.W.) through a gastric tube for one month and Group ӀV received concomitant daily doses of Bisphenol A and Curcumin as the regimen described in groups ӀӀ and ӀӀӀ. The rats were sacrificed, and glandular portion of stomach was dissected and processed for light, immunohistochemical and ultrastructural study. BPA induced destructed gastric glands, dilated congested blood vessels, submucosal oedema, decreased PAS-positive reactivity, increased collagen fibres deposition, decrease in the positive BCL2 immunoexpression, increased positive PCNA immunoexpression, reduction in the gastric mucosal height and destructive changes in the enteroendocrine, chief and parietal cells. Curcumin coadministration provoked an obvious improvement in the gastric structure. BPA exposure has toxic effects on the glandular portion of the stomach in rats. Otherwise, Curcumin coadministration has exhibited protective impact on the architecture of the stomach.

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Protective Effect of Curcumin versus N-acetylcystein on Acetaminophen Induced Hepatotoxicity in Adult Albino Rats

Cited by 5 publications

References 46 publications

Does curcumin protect against hazards of aspartame intake on the cerebellar cortex of male adult albino rats? Histological and immunohistochemical study

Does curcumin protect against hazards of aspartame intake on the cerebellar cortex of male adult albino rats? Histological and immunohistochemical study

Effect of Potassium Bromate on the Liver of Adult Male Albino Rat and A Possible Protective Role of Vitamin C: Histological, Immunohistochemical, and Biochemical Study

Curcumin ameliorated low dose-Bisphenol A induced gastric toxicity in adult albino rats

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