Protective effect of dietary fenugreek (Trigonella foenum-graecum) seeds and garlic (Allium sativum) on induced oxidation of low-density lipoprotein in rats

Mukthamba, Puttaswamy; Srinivasan, Krishnapura

doi:10.1515/jbcpp-2015-0037

Cited by 18 publications

(3 citation statements)

References 40 publications

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“…The results of the present study suggest that a pohyherbal mixture supplementation significantly lowered serum TC, TG and LDL cholesterol concentrations in the test group when compared with the hyperlipidaemic control group. These findings are generally in accordance with the results from previous studies that showed improvements in TC and LDL cholesterol concentration in relation to consumption of these herbs [26][27][28][29]. The results are supported by previous studies.…”

Section: Discussionsupporting

confidence: 93%

Preventive effects of Trigonella foenum-graecum and Allium sativum against Triton induced hyperlipidaemia in rabbits

IMRAN,

Sohail,

Khan

et al. 2023

J Pre Clin Clin Res.

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Introduction and Objective. Hyperlipidaemia is the greatest risk factor of coronary heart disease and currently available hypolipidemic drugs have been associated with number of side effects. Several studies have demonstrated the role of Trigonella foenum-graecum and Allium sativum in improvement of lipid profile and suggest their use as alternative and natural source for prevention / long term management of hyperlipidaemia. Materials and method. The study investigates synergetic antihyperlipidemic effects of polyherbal formulation containing T. foenum-graecum seeds and A. sativum buds (ratio 7:3) in Triton-induced acute hyperlipidaemia in rabbits, and compared with standard Atorvastatin. All animals were fed their respective samples orally without any base material for the period of one week. On day 7, blood samples were collected directly from the marginal ear vein of all rabbits before dosing. Immediately after the last dose, Triton WR-1339 (200 mg/kg i.p.) (Tyloxapol) (Sigma-aldrich Corp., USA) in normal saline was injected into all groups. After 24 h of Triton injection, blood samples were again collected from marginal ear vein of all animals for analysis of total cholesterol (TC), triglycerides (TG), HDL cholesterol and LDL cholesterol. Results. Seven days pretreatment of polyherbal formulation clearly demonstrated significant anti-hyperlipidaemic effects by showing TC 40.4 (p <0.05*), TG 36.6 (p <0.01**), HDL 25.8 and LDL 10.6 mg/dl (p <0.01**) in comparison with control group that exhibited TC 94.6, TG 812.6, HDL 20 and LDL 91.6 mg/dl lipid values. The standard group also exhibited potent results by showing TC 46, TG 198.6 (p <0.01**), HDL 37.6 (p <0.05*) and LDL 31.6 mg/dl (p <0.05*) values. Conclusion. The results obtained suggest that the regular use of a moderate amount of T. foenum-graecum and A. sativum in the diet may offer protection against hyperlipidaemia.

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Section: Discussionsupporting

confidence: 93%

Preventive effects of Trigonella foenum-graecum and Allium sativum against Triton induced hyperlipidaemia in rabbits

IMRAN,

Sohail,

Khan

et al. 2023

J Pre Clin Clin Res.

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“…This finding was in accordance with a previous study that demonstrated the antioxidant effect of fenugreek, cinnamon, ALA, and vitamin D3. Fenugreek significantly lowered oxidized LDL-C 52 and decreased MDA levels 53 in an animal study. Moreover, cinnamon suppresses lipid peroxidation via enhancement of hepatic antioxidant enzyme activity.…”

Section: Discussionmentioning

confidence: 88%

Nutraceutical Improves Glycemic Control, Insulin Sensitivity, and Oxidative Stress in Hyperglycemic Subjects: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial

Bumrungpert

Pavadhgul

Chongsuwat

et al. 2020

Natural Product Communications

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The aim of this research was to investigate the effects of nutraceuticals including bitter melon, fenugreek, cinnamon, alpha-lipoic acid, zinc, biotin, chromium, and cholecalciferol on glycemic control, insulin sensitivity, lipid profiles, oxidative stress, and inflammatory markers in hyperglycemia. The study design was a randomized, double-blind, placebo-controlled trial. Subjects with hyperglycemia were randomly divided into 2 groups. The treatment group ( n = 52) was given a nutraceutical and the control group ( n = 50) was provided with a placebo for 12 weeks. Fasting blood glucose (FBG), hemoglobin A1c (HbA1C), homeostatic model assessment of insulin resistance (HOMA-IR), lipid profiles, biomarkers of oxidative stress, and inflammation were assessed before and after the intervention at 6 weeks and 12 weeks. Nutraceutical supplementation demonstrated a statistically significant decrease in FBG (13.4% and 18.9%), HbA1C (6.5% and 11.3%), and HOMA-IR (28.9% and 35.2%) compared with the placebo. Moreover, low-density lipoprotein-cholesterol (LDL-C) level was significantly reduced in the nutraceutical group (7.1% and 9.3%). Furthermore, the nutraceutical significantly decreased oxidative stress markers, oxidized LDL-C (14.8% and 18.9%) and malondialdehyde (16.6% and 26.2%) compared with the placebo. In conclusion, this nutraceutical can improve glycemic control, insulin resistance, lipid profiles, and oxidative stress markers in hyperglycemic subjects. Therefore, it has the potential to decrease cardiovascular disease risk factors. Clinical trial registration: TCTR20180907001, www.clinicaltrials.in.th.

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“…It has been in use for over 2,500 years, mainly in Asia, Africa and Latin America, and has been employed for numerous medicinal purposes including as an antibacterial, gastric stimulant and antidiabetic agent. In recent decades, the therapeutic benefits of fenugreek have been identified in animal studies as well as human trials, including antidiabetic 2 – 5 , anti-infective 6 , 7 , anti-inflammatory 8 – 11 , anticancer 12 – 15 , hypolipidemic 16 – 18 , hypocholesterolemic 2 , 3 , 5 , 19 , antioxidant 8 , 20 – 22 , cardioprotective 23 – 26 and digestive stimulant activities 27 . 4-hydroxyisoleucine (4-HIL), which is extracted from fenugreek seeds, is a major compound that contributes to the physiological function of fenugreek.…”

Section: Introductionmentioning

confidence: 99%

Engineering a short-chain dehydrogenase/reductase for the stereoselective production of (2S,3R,4S)-4-hydroxyisoleucine with three asymmetric centers

Shi

Miyakawa

Nakamura

et al. 2017

Sci Rep

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Fenugreek is a dietary supplement for anti-aging and human health. (2S,3R,4S)-4-hydroxyisoleucine (4-HIL), which is extracted from fenugreek seeds, is expected to be a promising orally active drug for diabetes and diabetic nephropathy because of its insulinotropic effect. Although several chemical synthesis methods of 4-HIL have been proposed, these methods require multistep reactions to control the stereochemistry of 4-HIL. In this study, we modified the key enzyme 4-HIL dehydrogenase (HILDH) to overcome the biggest limitation in commercial-scale production of 4-HIL. As a result, an effective one-step carbonyl reduction to produce (2S,3R,4S)-4-HIL was successfully accomplished with strict stereoselectivity (>99% de). Mass production of (2S,3R,4S)-4-HIL by our synthetic method could have a significant contribution to the prevention of diabetes, dyslipidemia, and Alzheimer’s disease. (120 words/200 words)

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Protective effect of dietary fenugreek (Trigonella foenum-graecum) seeds and garlic (Allium sativum) on induced oxidation of low-density lipoprotein in rats

Abstract: The protective effect of dietary fenugreek and garlic on LDL oxidation both in vivo and in vitro as evidenced in the present study is suggestive of their cardioprotective potential since LDL oxidation is a key factor in the arteriosclerotic process.

Cited by 18 publications

References 40 publications

Preventive effects of <i>Trigonella foenum-graecum</i> and <i>Allium sativum</i> against Triton induced hyperlipidaemia in rabbits

Preventive effects of <i>Trigonella foenum-graecum</i> and <i>Allium sativum</i> against Triton induced hyperlipidaemia in rabbits

Nutraceutical Improves Glycemic Control, Insulin Sensitivity, and Oxidative Stress in Hyperglycemic Subjects: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial

Engineering a short-chain dehydrogenase/reductase for the stereoselective production of (2S,3R,4S)-4-hydroxyisoleucine with three asymmetric centers

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