Protective effect of dietary flavonoid quercetin against lipemic-oxidative hepatic injury in hypercholesterolemic rats

Mariee, Amr D.; Abd‐Allah, Gamil M.; El-Beshbishy, Hesham A.

doi:10.3109/13880209.2012.655424

Cited by 50 publications

(25 citation statements)

References 45 publications

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“…This similar observation has also been reported for a polar soluble fraction of Ocimum basilicum which is reported to significantly reduce the elevated blood concentrations of TGs [36]. The presence of flavonoids like rutin, quercetin, kaempferol in the leaves might also be responsible for hypo cholesterol activity through different mechanisms, which were previously reported by other authors [37][38][39]. Another class of compounds called sterols is also reported from the alcoholic extract of Moringa leaves [40,41].…”

Section: Discussionsupporting

confidence: 82%

Cholesterol Lowering Potentials of a Blend of Standardized Methanol Extracts of Moringa Oleifera Leaves and Fruits in Albino Wistar Rats

Gururaja

Mundkinajeddu

Kumar

et al. 2016

Int J Pharm Pharm Sci

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Objective: Moringa oleifera Lam. (Moringaceae), a small rapid growing, evergreen, deciduous tree is an important medicinal plant. Leaves and fruits of this plant are used for various ailments, as a nutritional supplement and also as vegetables. The current study involves in the determination of best combination of the cholesterol-lowering potential of a blend of methanol extracts of M. oleifera leaf and fruits, developed based on in vitro FIC index studies and evaluate the combination of this extracts in hypercholesterolemic animal models. Methods:Leaf and fruit methanol extracts and their combinations were tested in in vitro lipase inhibition assay to determine the best combination using fractional inhibitory concentration (FIC) index. Hypercholesterolemia was induced with Triton WR-1339 (a non-ionic detergent) and with high cholesterol diet for acute and chronic model respectively and the cholesterol-lowering effect of 1:1 blend of M. oleifera leaf and fruits methanol extracts was evaluated. Results:The FIC index values indicated that M. oleifera leaf and fruit extracts blended in 1:1 proportion was the best combination in in vitro lipase inhibition assay. This blend, when evaluated in vivo, showed a significant decrease in serum total cholesterol level from 24 h through 48 h in triton model. In high cholesterol diet model, the extract blend showed a significant reduction in serum triglycerides levels at 3 and 6 w of treatment. Conclusion:The results indicate that the blend of M. oleifera at the tested dose could be lowering cholesterol and triglyceride levels by inhibiting the absorption of cholesterol and can be developed as a standardized blend for dietary supplement market.

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Section: Discussionsupporting

confidence: 82%

Cholesterol Lowering Potentials of a Blend of Standardized Methanol Extracts of Moringa Oleifera Leaves and Fruits in Albino Wistar Rats

Gururaja

Mundkinajeddu

Kumar

et al. 2016

Int J Pharm Pharm Sci

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show abstract

“…Interestingly, it has been reported that quercetin induced the expression of endothelial nitric oxide synthase (eNOS) and inhibited its phosphorylation, thus enhancing the formation of NO [45][46][47]. In addition, animal study of Mariee et al [48] supported this issue and reported that quercetin was able to increase hepatic levels of NO which was significantly reduced through feeding of high cholesterol diet to rats. On the other hand, Dias et al [49] and Jo et al [50] reported that quercetin decreased the levels of NO through inhibition of inducible nitric oxide synthase (iNOS) overexpression.…”

Section: Discussionmentioning

confidence: 85%

Quercetin protects against acetaminophen-induced hepatorenal toxicity by reducing reactive oxygen and nitrogen species

et al. 2015

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“…HPTLC of CAME confirmed the presence of significant amount of the quercetin. Quercetin, a dietary-derived flavonoid, is ubiquitous in fruits and vegetables and plays important roles in human health by virtue of its antioxidant activity (Mariee et al, 2012). Both in vitro and in vivo studies suggest that quercetin ameliorates inflammation by inhibition of either the secretion of inflammatory mediators such as nitrogen reactive species produced after induction of iNOS expression or the expression and subsequent release of cytokines such as TNF-a and IL-1b (Comalada et al, 2005).…”

Section: Discussionmentioning

confidence: 99%

Inhibitory effect ofCareya arboreaon inflammatory biomarkers in carrageenan-induced inflammation

Begum

Sharma

Pillai

et al. 2014

Pharmaceutical Biology

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Context: Careya arborea Roxb. (Lecythidaceae) has multiple applications in traditional medicine; it exhibits analgesic, antibacterial, anti-inflammatory, antiulcer, and protective effects. However, the effect of C. arborea on biochemical and immmunological inflammatory mediators has not been explored. Objective: The present study investigates the anti-inflammatory potential of the methanol extract of C. arborea stem bark and further assesses its possible mechanism on the modulation of inflammatory biomarkers. Materials and methods: Anti-inflammatory activity of C. arborea methanol extract (CAME) was evaluated (100 and 200 mg/kg, p.o) using indomethacin (10 mg/kg, p.o) as the standard drug in Wistar albino rats. Inflammation was induced by injecting 0.1 ml carrageenan (1% w/v) into the left hind paw. The anti-inflammatory mechanism was studied by measuring malondialdehyde (MDA), C-reactive protein (CRP), nitric oxide (NO), myeloperoxidase (MPO), TNF-a, and IL-1b levels in both control and treated groups. A protocol has also been established to quantify quercetin and betulinic acid content in CAME using HPTLC fingerprint. Results: Careya arborea significantly (p50.001) decreased carrageenan-induced paw edema, showed a reduction of 48.87 and 65.53% at doses of 100 and 200 mg/kg, respectively. Moreover, CAME significantly decreased the MDA, CRP, NO, and MPO levels, elevated by carrageenan induced inflammation. CAME also markedly down-regulated serum TNF-a and IL-1b levels. These findings were further supported by the histological study. The content of quercetin and betulinic acid in CAME was found to be 0.177 and 3.14%, respectively. Conclusion: Several mechanisms, including the inhibition of pro-inflammatory cytokines, enzymes and mediators release, appear to account for the anti-inflammatory potential of C. arborea.

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Protective effect of dietary flavonoid quercetin against lipemic-oxidative hepatic injury in hypercholesterolemic rats

Cited by 50 publications

References 45 publications

Cholesterol Lowering Potentials of a Blend of Standardized Methanol Extracts of Moringa Oleifera Leaves and Fruits in Albino Wistar Rats

Cholesterol Lowering Potentials of a Blend of Standardized Methanol Extracts of Moringa Oleifera Leaves and Fruits in Albino Wistar Rats

Quercetin protects against acetaminophen-induced hepatorenal toxicity by reducing reactive oxygen and nitrogen species

Inhibitory effect ofCareya arboreaon inflammatory biomarkers in carrageenan-induced inflammation

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