Protective effect of diosmin against diabetic neuropathy in experimental rats

Jain, Dilpesh; Bansal, Manish; Dalvi, Rahul M.; Upganlawar, Aman B.; Somani, Rahul

doi:10.1016/s2095-4964(14)60001-7

Cited by 88 publications

(50 citation statements)

References 27 publications

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“…[18] Reduced anabolic insulin hormone in DM, promotes protein catabolism and releasing amino acids for gluconeogenesis [19] which leads to increased muscle wasting due to loss of tissue proteins and reduction of body weight. [20] In the current study, all diabetic groups maintained the hyperglycemic state throughout the experimental period and showed progressive reduction in body weight in the STZ-induced rats, reflecting an increase in protein catabolism and loss of tissue proteins. This result is in agreement with previous related studies.…”

Section: Discussionsupporting

confidence: 49%

Effect of streptozotocin-induced diabetes on the autonomic ganglia of albino rats

Faizal¹,

Khan²

2017

Anatomy

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Objectives: One of the common clinical observations regarding long-standing hyperglycemia is autonomic neuropathy, probably due to its unfavorable destructive effects on the neurons of the autonomic ganglia. Accordingly, the current study was aimed to analyze the effect of experimental hyperglycemia on parasympathetic pterygopalatine ganglion (PtG) and sympathetic coeliac ganglion (ClG) of albino rats.Methods: Thirty-six albino rats were divided into six groups (n=6, each) and were designated as control, two weeks, one month, two months, four months and six months groups. Diabetes was induced with a single dose of streptozotocin (STZ, 60 mg/kg, i.p.). Body weight and blood sugar were monitored at biweekly intervals. At the end of each experimental period, animals were euthanized by deep ether anesthesia and blood samples were collected by direct puncture of heart for biochemical analysis. Animals were perfused with Karnovsky fixative. After 48 hours, tissue samples were collected and processed for light microscopy.Results: Biochemical analysis of serum revealed increased serum creatinine and reduced serum total protein. Histopathology and histomorphometry of ganglia revealed that the progressively increasing duration of hyperglycemia was associated with decreased proportion of small-sized neurons, increased proportion of large-sized neurons, dark and dead neurons, and thickening of capsular and endoneurial collagen. Conclusion:The association of the long-standing hyperglycemia with increased neuronal death, altered proportion of neurons and deposition of collagen fibers in autonomic ganglia appear to be important contributing factors likely to be responsible for diabetic autonomic neuropathy.

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Section: Discussionsupporting

confidence: 49%

Effect of streptozotocin-induced diabetes on the autonomic ganglia of albino rats

Faizal¹,

Khan²

2017

Anatomy

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“…Excessive production of free fatty acids (hyperglycaemia) has previously been shown to cause inflammation leading to mitochondrial DNA damage and pancreatic cell malfunctioning [141]. Antioxidant supplementation by diosmin suppressed diabetes induced ROS resulting in deactivation of NF-κB associated pro-inflammatory chemokines and cytokines such as macrophage chemotactic protein (MCP-1), tumor necrosis factor (TNF-α), and interleukins (IL-1β and 6) [98]. …”

Section: Natural Anti-diabetic/inflammatory Bioactive Compounds Anmentioning

confidence: 99%

Natural Phyto-Bioactive Compounds for the Treatment of Type 2 Diabetes: Inflammation as a Target

et al. 2016

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Diabetes is a metabolic, endocrine disorder which is characterized by hyperglycemia and glucose intolerance due to insulin resistance. Extensive research has confirmed that inflammation is closely involved in the pathogenesis of diabetes and its complications. Patients with diabetes display typical features of an inflammatory process characterized by the presence of cytokines, immune cell infiltration, impaired function and tissue destruction. Numerous anti-diabetic drugs are often prescribed to diabetic patients, to reduce the risk of diabetes through modulation of inflammation. However, those anti-diabetic drugs are often not successful as a result of side effects; therefore, researchers are searching for efficient natural therapeutic targets with less or no side effects. Natural products’ derived bioactive molecules have been proven to improve insulin resistance and associated complications through suppression of inflammatory signaling pathways. In this review article, we described the extraction, isolation and identification of bioactive compounds and its molecular mechanisms in the prevention of diabetes associated complications.

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“…Treatment with diosmin significantly restored the reduced body weight, elevated blood sugar and lipid profiles and caused improvement in thermal hyperalgesia, cold allodynia and walking function in diabetic rats treated with diosmin. Four weeks of diosmin treatment restored elevated levels of malondialdehyde, nitric oxide and decreased glutathione levels and superoxide dismutase activity 30 .…”

Section: Diosminmentioning

confidence: 88%

Untitled

2016

IJPSR

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Type 2 diabetes is a serious health problem globally. In type 2 diabetes insulin resistance in various tissues such as liver, muscle and β-cell is the major pathophysiological defects. People with long term uncontrolled hyperglycemia are at risk of developing a number of serious and life-threatening complications which mainly affect the heart and blood vessels, eyes, kidneys, and nerves. Current drug development strategy has focused towards the control of hyperglycemia but the treatment of severe complications has been neglected. Many herbs including Momordica charantia, Coccinia indica, Ficus carica, Gymnema sylvestre, Ocimum santum and many more have traditionally been used for the treatment of diabetes and associated complications. Natural products have been reported to have their efficacy in diabetes and its complications by protecting pancreatic β-cells, increasing insulin sensitivity, reducing oxidative stress and by targeting various proteins. Thus, now a day plant based natural product (phytoconstituents) have been the basis of drug development program for the treatment of various diseases. The present review summarizes the latest updates on phytochemicals from different class of secondary metabolites with potential effect in type 2 diabetic complications.

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Protective effect of diosmin against diabetic neuropathy in experimental rats

Cited by 88 publications

References 27 publications

Effect of streptozotocin-induced diabetes on the autonomic ganglia of albino rats

Effect of streptozotocin-induced diabetes on the autonomic ganglia of albino rats

Natural Phyto-Bioactive Compounds for the Treatment of Type 2 Diabetes: Inflammation as a Target

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