2023
DOI: 10.1016/j.cbi.2023.110399
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Protective effect of eicosapentaenoic acid against estradiol valerate-induced endometrial hyperplasia via modulation of NF-κB/HIF-1α/VEGF signaling pathway in rats

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Cited by 2 publications
(3 citation statements)
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“…First, activated HIF-1α allows tumor cells to efficiently use energy in the hostile microenvironment, facilitating their survival [ 99 ]. In early endometrial cancer or endometrial hyperplasia, the upregulation of HIF-1α can lead to the overexpression of VEGF, leading to the appearance of neovascularization, providing an important process of nutrient acquisition [ 100 ]. Conversely, the administration of eicosapentaenoic acid, a predominant omega-3 polyunsaturated fatty acid known for enhancing antioxidant enzyme activities, negatively modulates the HIF-1α/VEGF signaling pathway, countering endometrial hyperplasia [ 100 ].…”
Section: Pathological Roles Of Endometrial Hif-1αmentioning
confidence: 99%
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“…First, activated HIF-1α allows tumor cells to efficiently use energy in the hostile microenvironment, facilitating their survival [ 99 ]. In early endometrial cancer or endometrial hyperplasia, the upregulation of HIF-1α can lead to the overexpression of VEGF, leading to the appearance of neovascularization, providing an important process of nutrient acquisition [ 100 ]. Conversely, the administration of eicosapentaenoic acid, a predominant omega-3 polyunsaturated fatty acid known for enhancing antioxidant enzyme activities, negatively modulates the HIF-1α/VEGF signaling pathway, countering endometrial hyperplasia [ 100 ].…”
Section: Pathological Roles Of Endometrial Hif-1αmentioning
confidence: 99%
“…In early endometrial cancer or endometrial hyperplasia, the upregulation of HIF-1α can lead to the overexpression of VEGF, leading to the appearance of neovascularization, providing an important process of nutrient acquisition [ 100 ]. Conversely, the administration of eicosapentaenoic acid, a predominant omega-3 polyunsaturated fatty acid known for enhancing antioxidant enzyme activities, negatively modulates the HIF-1α/VEGF signaling pathway, countering endometrial hyperplasia [ 100 ]. Additionally, kinesin family member 23, a novel target in endometrial cancer, responds to HIF-1α by promoting the conversion of pyruvate to lactate, thereby developing the “Warburg effect” and enhancing cancer cell proliferation [ 101 ].…”
Section: Pathological Roles Of Endometrial Hif-1αmentioning
confidence: 99%
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