Protective Effect of Emblica officinalis Against Alcohol-Induced Hepatic Injury by Ameliorating Oxidative Stress in Rats

Reddy, Vaddi Damodara; Padmavathi, P.; Sriram, G; Maturu, Paramahamsa; Nallanchakravarthula, Varadacharyulu

doi:10.1007/s12291-010-0058-2

Cited by 38 publications

(11 citation statements)

References 38 publications

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“…A recent clinical study showed that Amla extract improved endothelial function in patients with type 2 diabetes mellitus [ 3 ]. Furthermore, its antioxidant [ 4 ], hepatoprotective [ 5 ], nephroprotective [ 6 ], hypolipidemic [ 7 , 8 ], cardioprotective [ 9 , 10 ], and antidiabetic effects [ 11 ] were demonstrated in in vivo animal models. One potential mechanism for these effects was reduction of oxidative stress, based on observations of decreased oxidative stress with Amla treatment.…”

Section: Introductionmentioning

confidence: 99%

Amla Enhances Mitochondrial Spare Respiratory Capacity by Increasing Mitochondrial Biogenesis and Antioxidant Systems in a Murine Skeletal Muscle Cell Line

Yamamoto

Morino

Lemecha

et al. 2016

Oxidative Medicine and Cellular Longevity

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Amla is one of the most important plants in Indian traditional medicine and has been shown to improve various age-related disorders while decreasing oxidative stress. Mitochondrial dysfunction is a proposed cause of aging through elevated oxidative stress. In this study, we investigated the effects of Amla on mitochondrial function in C2C12 myotubes, a murine skeletal muscle cell model with abundant mitochondria. Based on cell flux analysis, treatment with an extract of Amla fruit enhanced mitochondrial spare respiratory capacity, which enables cells to overcome various stresses. To further explore the mechanisms underlying these effects on mitochondrial function, we analyzed mitochondrial biogenesis and antioxidant systems, both proposed regulators of mitochondrial spare respiratory capacity. We found that Amla treatment stimulated both systems accompanied by AMPK and Nrf2 activation. Furthermore, we found that Amla treatment exhibited cytoprotective effects and lowered reactive oxygen species (ROS) levels in cells subjected to t-BHP-induced oxidative stress. These effects were accompanied by increased oxygen consumption, suggesting that Amla protected cells against oxidative stress by using enhanced spare respiratory capacity to produce more energy. Thus we identified protective effects of Amla, involving activation of mitochondrial function, which potentially explain its various effects on age-related disorders.

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Section: Introductionmentioning

confidence: 99%

Amla Enhances Mitochondrial Spare Respiratory Capacity by Increasing Mitochondrial Biogenesis and Antioxidant Systems in a Murine Skeletal Muscle Cell Line

Yamamoto

Morino

Lemecha

et al. 2016

Oxidative Medicine and Cellular Longevity

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“…For example, quercetin prevents ethanol-induced dyslipidemia and mitochondrial oxidative damage [ 37 ]. Another report suggested that Emblica officinalis prevents ethanol-induced hepatic injury by ameliorating oxidative stress [ 38 ]. In this study, antioxidative functions in the liver of radon-inhaled and alcohol-administrated mice were significantly higher than in sham-inhaled and alcohol-administrated mice.…”

Section: Discussionmentioning

confidence: 99%

Inhibitory Effects of Pretreatment with Radon on Acute Alcohol-Induced Hepatopathy in Mice

Toyota

Kataoka

Nishiyama

et al. 2012

Mediators of Inflammation

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We previously reported that radon inhalation activates antioxidative functions in the liver and inhibits carbon tetrachloride-induced hepatopathy in mice. In addition, it has been reported that reactive oxygen species contribute to alcohol-induced hepatopathy. In this study, we examined the inhibitory effects of radon inhalation on acute alcohol-induced hepatopathy in mice. C57BL/6J mice were subjected to intraperitoneal injection of 50% alcohol (5 g/kg bodyweight) after inhaling approximately 4000 Bq/m3 radon for 24 h. Alcohol administration significantly increased the activities of glutamic oxaloacetic transaminase (GOT), glutamic pyruvic transaminase (GPT) in serum, and the levels of triglyceride and lipid peroxide in the liver, suggesting acute alcohol-induced hepatopathy. Radon inhalation activated antioxidative functions in the liver. Furthermore, pretreatment with radon inhibited the depression of hepatic functions and antioxidative functions. These findings suggested that radon inhalation activated antioxidative functions in the liver and inhibited acute alcohol-induced hepatopathy in mice.

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“…37 Damodara et al, also reported in their in vitro study that no scavenging compounds were present in Emblica officinalis, as this might protect from free radical-mediated oxidative stress in the hepatocytes of rats with alcohol stimulated liver damage. 38 Amla decreased autophagy presences through Beclin-1 and Bax/Bcl-2 down-regulation and decreased the level of N-nitrosodiethylamine-enhanced hepatic apoptosis. Thus, supplementation with amla counteracts N-nitrosodiethylamine stimulated liver damage through its anti-autophagy, anti-apoptosis, antioxidant and anti-inflammation characteristics.…”

Section: Emblica Officinalismentioning

confidence: 92%

Updates on Traditional Medicinal Plants for Hepatocellular Carcinoma

Mathew¹,

Faheem²,

Suhail³

et al. 2016

Phcogj

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Aim: Hepatocellular carcinoma (HCC) is a major worldwide problem primarily caused by hepa titis B and C virus infection. End stage liver cancer treatment options are limited thus requiring expensive liver transplantation which is not available in many countries. Methods: Several herbal compounds and herbal composite formulas have been studied through in-vitro and in vivo as an anti-HCC agent, enhancing our knowledge about their biological functions and targets. In this article, arecent update on the herbal medicine has been provided with reference to liver cancer. Results: For the sake of clarity, the effective herbal compounds, clinical studies of herbal composite formula, cell culture, and animal model studies safety are discussed. The effects of many herbal active compounds of Annona atemoya, Andrographis paniculata, Boerha viadiffusa, Piper longum, Podophyllum hexandrum, Phyllanthus amarus, and Terminalia chebula, and herbal composite formula on autophagy, apoptosis, antioxidant, and inflammation characteristicshave been provided. Conclusion: This will enhance our understanding on the prevention and treatment of HCC by herbal active compounds and herbal composite formulas.

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Protective Effect of Emblica officinalis Against Alcohol-Induced Hepatic Injury by Ameliorating Oxidative Stress in Rats

Cited by 38 publications

References 38 publications

Amla Enhances Mitochondrial Spare Respiratory Capacity by Increasing Mitochondrial Biogenesis and Antioxidant Systems in a Murine Skeletal Muscle Cell Line

Amla Enhances Mitochondrial Spare Respiratory Capacity by Increasing Mitochondrial Biogenesis and Antioxidant Systems in a Murine Skeletal Muscle Cell Line

Inhibitory Effects of Pretreatment with Radon on Acute Alcohol-Induced Hepatopathy in Mice

Updates on Traditional Medicinal Plants for Hepatocellular Carcinoma

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