Protective Effect of (−)Epigallocatechin-3-gallate on Rotenone-Induced Parkinsonism-like Symptoms in Rats

Tseng, Hsiang-Chien; Wang, Mao‐Hsien; Chang, Kuan‐Chang; Soung, Hung-Sheng; Fang, Chia Lang; Lin, Yi‐Wen; Li, Keng-Yuan; Yang, Chao‐Hsun; Tsai, Cheng-Chia

doi:10.1007/s12640-019-00143-6

Cited by 56 publications

(51 citation statements)

References 49 publications

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“…In rotenoneinduced rat PD models, EGCG treatment reduced lipid peroxidation production and NO levels, increased succinate dehydrogenase (SDH) activity, improved mitochondrial function, and raised ATPase and ST catecholamine levels. In addition, EGCG treatment decreased the level of neuroinflammatory cytokines and apoptotic markers and improved motor performance [302]. Administration of EGCG in MPTP-induced mice prevented neurotoxin-induced reduction in ST antioxidant enzymes SOD and CAT and increased the activities of both enzymes in the total brain [303].…”

Section: Neuroprotective Mechanisms Of Thymoquinone In Pdmentioning

confidence: 94%

Natural Phytochemicals as Novel Therapeutic Strategies to Prevent and Treat Parkinson’s Disease: Current Knowledge and Future Perspectives

Balakrishnan

Azam

Cho

et al. 2021

Oxidative Medicine and Cellular Longevity

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Parkinson’s disease (PD) is the second-most common neurodegenerative chronic disease affecting both cognitive performance and motor functions in aged people. Yet despite the prevalence of this disease, the current therapeutic options for the management of PD can only alleviate motor symptoms. Research has explored novel substances for naturally derived antioxidant phytochemicals with potential therapeutic benefits for PD patients through their neuroprotective mechanism, targeting oxidative stress, neuroinflammation, abnormal protein accumulation, mitochondrial dysfunction, endoplasmic reticulum stress, neurotrophic factor deficit, and apoptosis. The aim of the present study is to perform a comprehensive evaluation of naturally derived antioxidant phytochemicals with neuroprotective or therapeutic activities in PD, focusing on their neuropharmacological mechanisms, including modulation of antioxidant and anti-inflammatory activity, growth factor induction, neurotransmitter activity, direct regulation of mitochondrial apoptotic machinery, prevention of protein aggregation via modulation of protein folding, modification of cell signaling pathways, enhanced systemic immunity, autophagy, and proteasome activity. In addition, we provide data showing the relationship between nuclear factor E2-related factor 2 (Nrf2) and PD is supported by studies demonstrating that antiparkinsonian phytochemicals can activate the Nrf2/antioxidant response element (ARE) signaling pathway and Nrf2-dependent protein expression, preventing cellular oxidative damage and PD. Furthermore, we explore several experimental models that evaluated the potential neuroprotective efficacy of antioxidant phytochemical derivatives for their inhibitory effects on oxidative stress and neuroinflammation in the brain. Finally, we highlight recent developments in the nanodelivery of antioxidant phytochemicals and its neuroprotective application against pathological conditions associated with oxidative stress. In conclusion, naturally derived antioxidant phytochemicals can be considered as future pharmaceutical drug candidates to potentially alleviate symptoms or slow the progression of PD. However, further well-designed clinical studies are required to evaluate the protective and therapeutic benefits of phytochemicals as promising drugs in the management of PD.

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Section: Neuroprotective Mechanisms Of Thymoquinone In Pdmentioning

confidence: 94%

Natural Phytochemicals as Novel Therapeutic Strategies to Prevent and Treat Parkinson’s Disease: Current Knowledge and Future Perspectives

Balakrishnan

Azam

Cho

et al. 2021

Oxidative Medicine and Cellular Longevity

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“…In an evaluation of the neuroprotective effects of EGCG on ROT-treated dissociated mesencephalic cultures and organotypic striatal cultures, EGCG partially counteracted the effects of ROT in striatal slice cultures through the reduction of nitric oxide (NO) but did not dissociate cells against ROT toxicity [178]. Although the latter study did not demonstrate that EGCG protects against ROT-induced neurotoxicity in cell models, it was recently reported that EGCG had a neuroprotective effect in vivo on ROT-induced PD models [206,207]. Together, these results from in vitro neurotoxicity models support the notion that EGCG can be used as a neuroprotective agent to treat NDs.…”

Section: Evidence From In Vitro Neurotoxicity Modelsmentioning

confidence: 98%

“…Reduces NO level and lipid peroxidation production, increases the levels of catecholamines in the striatum, and reduces the levels of neuroinflammatory and apoptotic markers [207] Amyotrophic lateral sclerosis…”

Section: Experimental Models Animal Strain Outcomesmentioning

confidence: 99%

“…This study demonstrated that the possible neuroprotective effects of EGCG (100 or 300 mg/kg i.p.) against ROT-induced motor and neurochemical dysfunctions in rats are associated with its antioxidant effects, prevention of mitochondrial dysfunction, prevention of neurochemical deficiency, antineuroinflammatory effects, and anti-apoptotic effects [207].…”

Section: Evidence From Animal Modelsmentioning

confidence: 99%

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Green Tea Epigallocatechin-3-gallate (EGCG) Targeting Protein Misfolding in Drug Discovery for Neurodegenerative Diseases

2021

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The potential to treat neurodegenerative diseases (NDs) of the major bioactive compound of green tea, epigallocatechin-3-gallate (EGCG), is well documented. Numerous findings now suggest that EGCG targets protein misfolding and aggregation, a common cause and pathological mechanism in many NDs. Several studies have shown that EGCG interacts with misfolded proteins such as amyloid beta-peptide (Aβ), linked to Alzheimer’s disease (AD), and α-synuclein, linked to Parkinson’s disease (PD). To date, NDs constitute a serious public health problem, causing a financial burden for health care systems worldwide. Although current treatments provide symptomatic relief, they do not stop or even slow the progression of these devastating disorders. Therefore, there is an urgent need to develop effective drugs for these incurable ailments. It is expected that targeting protein misfolding can serve as a therapeutic strategy for many NDs since protein misfolding is a common cause of neurodegeneration. In this context, EGCG may offer great potential opportunities in drug discovery for NDs. Therefore, this review critically discusses the role of EGCG in NDs drug discovery and provides updated information on the scientific evidence that EGCG can potentially be used to treat many of these fatal brain disorders.

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“…Neuroinflammation occurring during PD induces the expression of inflammatory mediators like TNF-α and interleukins and plays a major role in the initiation of apoptosis. In the rotenone-induced rat PD model, EGCG treatment significantly downregulated the expression of TNF-α, IL-1, IL-6, and showed a neuroprotective effect [ 119 ].…”

Section: Neuroprotective Properties Of Green Tea Against Parkinsonmentioning

confidence: 99%

Neuroprotective Properties of Green Tea (Camellia sinensis) in Parkinson’s Disease: A Review

et al. 2020

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Neurodegenerative disease is a collective term given for the clinical condition, which results in progressive degeneration of neurons and the loss of functions associated with the affected brain region. Apart from the increase in age, neurodegenerative diseases are also partly affected by diet and lifestyle practices. Parkinson’s disease (PD) is a slow onset neurodegenerative disorder and the second most common neurodegenerative disease, which affects the motor system. Although there is no prescribed treatment method to prevent and cure PD, clinical procedures help manage the disease symptoms. Green tea polyphenols are known for several health benefits, including antioxidant, anti-inflammatory, and neuroprotective activity. The current manuscript summarizes the possible mechanisms of neuroprotective potential of green tea with a special focus on PD. Studies have suggested that the consumption of green tea protects against free-radicals, inflammation, and neuro-damages. Several in vivo studies aid in understanding the overall mechanism of green tea. However, the same dose may not be sufficient in humans to elicit similar effects due to complex physiological, social, and cultural development. Future research focused on more clinical trials could identify an optimum dose that could impart maximum health benefits to impart neuroprotection in PD.

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Protective Effect of (−)Epigallocatechin-3-gallate on Rotenone-Induced Parkinsonism-like Symptoms in Rats

Cited by 56 publications

References 49 publications

Natural Phytochemicals as Novel Therapeutic Strategies to Prevent and Treat Parkinson’s Disease: Current Knowledge and Future Perspectives

Natural Phytochemicals as Novel Therapeutic Strategies to Prevent and Treat Parkinson’s Disease: Current Knowledge and Future Perspectives

Green Tea Epigallocatechin-3-gallate (EGCG) Targeting Protein Misfolding in Drug Discovery for Neurodegenerative Diseases

Neuroprotective Properties of Green Tea (Camellia sinensis) in Parkinson’s Disease: A Review

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