Protective effect of epigallocatechin gallate on brain damage after transient middle cerebral artery occlusion in rats

Adaptive Cellular Stress Pathways as Therapeutic Targets of Dietary Phytochemicals: Focus on the Nervous System

“…Neuroprotective effects of green tea extract and its active polyphenol, (2)-EGCG, have been widely reported in ischemic brain injury models (Hong et al, 2000(Hong et al, , 2001Choi et al, 2004;Egashira et al, 2007). In addition, the amino acid L-theanine in the tea leaves also shows a neuroprotective effect in animal models of stroke Zukhurova et al, 2013).…”

Green and Black Tea Consumption and Risk of Stroke

“…Further evidence supportive of this hypothesis comes from preclinical studies in which stroke was induced in rats, mice, and gerbils. In these experiments, either epigallocatechin gallate [12][13][14] or tea catechin extracts were given in doses ranging from 25 to 50 mg/kg intraperitoneally to rats subjected to cerebral arterial occlusion. They found reduced brain infarct area and stroke volume in an inverse dose-dependent fashion.…”

Efficacy of prophylactic flavan-3-ol in permanent focal ischemia in 12-mo-old mice

“…In the present study, use of 15 mg/kg EC extended its beneficial effect in aging mice and reduced infarct volume by 41.01 Ϯ 29.57%. Because polyphenolic compounds have been shown to improve outcomes in models of ischemia (7,27,29,50,58,59), the goal here was to evaluate possible effects on immune cell activation and cerebrovascular integrity. Interestingly, results did not support the hypothesized mechanisms.…”