Protective effect of ethanolic extract of Actinoscirpus grossus tubers against ethanol induced liver toxicity in albino rats

Ganapathi, Savin Chanthala; Holla, Rajendra; Shankara, Shivaraja; Mundugaru, Ravi; Kn, Sunilkumar; Rajagopal, Rajakrishnan; Alfarhan, Ahmed; Al-Ansari, Abdullah

doi:10.1016/j.jksus.2020.101253

Cited by 4 publications

(2 citation statements)

References 23 publications

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“…Liver is the target organ for ethanol metabolism and hence it is more prone to ethanol intoxication. Daily administration of 20% ethanol significantly increased liver enzymes and cause oxidative stress by increase in the lipid peroxidation and reduction in the catalase and glutathione peroxidase activity in liver homogenate (Ganapathi et al, 2021). Hepatocyte, by nature contains enzymatic and non-enzymatic molecules to combat oxidative stress.…”

Section: Discussionmentioning

confidence: 99%

Exploring the Hepatoprotective and Antioxidant Potential of Ficus racemosa Extract Against Ethanol – Induced Oxidative Stress in Wistar Albino Rats

B.L.,

2024

Intern. J. Bio. Env. Invest.

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The utilization of indigenous plants for the treatment of various ailments has gained substantial attention due to their therapeutic benefits. The present study aimed to investigate the hepatoprotective and antioxidant potential of Ficus racemosa against ethanol induced liver damage in male Wistar albino rats. In the present study, Group I served as Control. Ethanol is orally administered to Group II rats, which resulted in significant decrease in the levels of antioxidant enzymes such as GST, GPx, SOD and CAT. These antioxidant enzymes play a pivotal role in combating oxidative stress. Elevated levels of lipid peroxidation were also observed in the serum and liver tissue after Ethanol administration by estimating the level of TBARS. Treatment with Ficus racemosa leaf extract (Group III) led to a substantial increase in the levels of antioxidant enzymes, when compared with ethanol induced untreated rats. Silymarin is used as a standard reference drug which was administered to Ethanol induced Group IV rats. The results revealed that, the administration of Ficus racemosa extract possibly mitigate the damage caused by oxidative stress thus, suggesting its role as an excellent antioxidant in treating liver disorders.

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Section: Discussionmentioning

confidence: 99%

Exploring the Hepatoprotective and Antioxidant Potential of Ficus racemosa Extract Against Ethanol – Induced Oxidative Stress in Wistar Albino Rats

B.L.,

2024

Intern. J. Bio. Env. Invest.

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“…Liver is the target for toxins because of the gastrointestinal tract carries most toxins into the liver through the portal vein. Although the liver has enzymes that could metabolize the toxins into a less toxic substance, the high level of toxins can damage and kill the hepatocytes, marked by the increase of Serum Glutamic-pyruvic Transaminase (SGPT) and Serum Glutamic Oxaloacetic Transaminase (SGOT) level [13]. The liver, cardiac muscle, kidney, brain, pancreas, skeletal muscle, lung, erythrocytes, and leukocytes are just a few of the organs that contain SGOT.…”

Section: Introductionmentioning

confidence: 99%

Sub-Acute Toxicity Study of Pegagan Embun (Hydrocotyle Sibthorpioides Lam.) Extract on the SGPT and Sgot Level of Wistar White Male Rats

2023

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Objective: Pegagan embun (Hydrocotyle sibthorpioides Lam.) is one of the herbs used in ethnomedicines as an immunostimulant during the COVID-19 pandemic. This present study aims to discover the potential toxicity effect of pegagan embun extract through sub-acute administration on the SGPT and SGOT levels of Wistar white male rats. Methods: Thirty-six test animals were divided into four groups: the control group was given Na CMC 0.5%, and the treatment groups were treated with ethanol extract of pegagan embun at doses of 7, 35, and 150 mg/kgBW. All groups were treated orally for 7, 14, and 21 d once daily. On the 8th, 15th, and 22nd day, the SGPT and SGOT of the test animal level were measured. The data were analyzed by two-way ANOVA followed by Duncan’s multiple range test (p<0.05). Results: The study revealed that administration of pegagan embun extract did not cause any harmful effect on the liver but significantly decreased the level of SGPT and SGOT influenced by the variety of doses and duration of administration (p<0.05). Significant reductions in SGPT and SGOT levels are seen after extract administration at dosages of 7 mg/kgBW for 21 d. Conclusion: This study showed that pegagan embun (Hydrocotyle sibthorpioides Lam.) extract sub-acute administration at doses of 7, 35, and 150 mg/kgBW is relatively non-toxic and safe to be used as an immunostimulant. There was no sign of damage showed in the liver of treated rats based on the levels of SGOT and SGPT.

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Hydroethanolic extract of Gentiana kurroo Royle rhizome ameliorates ethanol-induced liver injury by reducing oxidative stress, inflammation and fibrogenesis in rats

Choubey,

Sharma,

Joshi

et al. 2024

Journal of Ethnopharmacology

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Protective effect of ethanolic extract of Actinoscirpus grossus tubers against ethanol induced liver toxicity in albino rats

Cited by 4 publications

References 23 publications

Exploring the Hepatoprotective and Antioxidant Potential of Ficus racemosa Extract Against Ethanol – Induced Oxidative Stress in Wistar Albino Rats

Exploring the Hepatoprotective and Antioxidant Potential of Ficus racemosa Extract Against Ethanol – Induced Oxidative Stress in Wistar Albino Rats

Sub-Acute Toxicity Study of Pegagan Embun (Hydrocotyle Sibthorpioides Lam.) Extract on the SGPT and Sgot Level of Wistar White Male Rats

Hydroethanolic extract of Gentiana kurroo Royle rhizome ameliorates ethanol-induced liver injury by reducing oxidative stress, inflammation and fibrogenesis in rats

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