Protective effect of exercise and alpha tocopherol on atherosclerosis promotion in hypercholesterolemic domestic rabbits

Shekh, Mudhir S.; Mahmud, Almas M. R.

doi:10.1063/1.5004326

Cited by 2 publications

(1 citation statement)

References 20 publications

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“…We also found that higher α -tocopherol concentration was associated with lower lipid peroxidation level in the heart, regardless of training. Shekh and Mahmud [ 72 ] suggest that the combination of moderate exercise with α -tocopherol can be exploited to prevent atherosclerosis in hypercholesterolemic rabbits. However, Patil et al [ 73 ] showed that antioxidant as α -tocopherol supplementation did not contribute significantly to improving the cardiopulmonary fitness of endurance athletes.…”

Section: Discussionmentioning

confidence: 99%

α-Tocopherol Protects the Heart, Muscles, and Testes from Lipid Peroxidation in Growing Male Rats Subjected to Physical Efforts

Górnicka

Ciecierska

Hamułka

et al. 2019

Oxidative Medicine and Cellular Longevity

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The effect of α-tocopherol supplementation on adaptation to training is still equivocal. The aim of the study was to determine the effect of training and α-tocopherol supplementation on α-tocopherol and thiobarbituric acid reactive substance (TBARS) concentration in the rat liver, heart, muscles, and testes. Male Wistar rats (n=32) were divided into four groups (nonsupplemented, not trained—C; nonsupplemented, trained—CT; supplemented, not trained—E; supplemented and trained—ET). During the 14-day experimental period, 2 mg/d of vitamin E as α-tocopherol acetate was administered to the animals (groups E and ET). Rats in the training group (CT and ET) were subjected to 15 minutes of treadmill running each day. The α-tocopherol levels in rat tissues were assessed using high-performance liquid chromatography (HPLC). Lipid peroxides were determined by TBARS spectrophotometric method. α-Tocopherol had a significant impact on α-tocopherol concentration in all tissues. Training increased the α-tocopherol concentration in the heart and muscles but reduced it in the liver. Training also caused increased lipid peroxidation in the muscles, heart, and testes; but a higher α-tocopherol content in tissues reduced the TBARS level. The main finding of the study is that impaired α-tocopherol status and its adequate intake is needed to maintain optimal status to prevent damage to the skeletal and cardiac muscles as well as the testes in growing individuals.

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Section: Discussionmentioning

confidence: 99%

α-Tocopherol Protects the Heart, Muscles, and Testes from Lipid Peroxidation in Growing Male Rats Subjected to Physical Efforts

Górnicka

Ciecierska

Hamułka

et al. 2019

Oxidative Medicine and Cellular Longevity

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Alpha-tocopherol and quercetin modulate primary hemodynamic parameters, oxidative stress indices, and biomarkers of cardio-renal functioning in ethanol-exposed rats

Ajibade,

Oyetunji,

Esan

et al. 2024

AJBPS

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Objectives: The objective of this study was the assessment of the ameliorative roles of alpha-tocopherol and quercetin on the toxic mechanisms associated with ethanol (EtoH) exposure in the cardiac and renal systems of rats. Material and Methods: Forty male rats were randomly selected and divided into five groups as follows: 0.2 mL distilled water; EtoH 40% v/v; EtoH + 2.5 mg/kg alpha-tocopherol; EtoH + 50 mg/kg quercetin; and EtoH + a cocktail of alpha-tocopherol and quercetin. Results: Treatment with alpha-tocopherol and quercetin significantly (P < 0.05) ameliorated EtoH-induced alterations in hemodynamic and electrocardiographic parameters, kidney function markers, and antioxidant defense status of rats with significantly elevated levels of glutathione, glutathione peroxidase, superoxide dismutase, and glutathione-S-transferase observed in antioxidant-treated rats. Histopathologic lesions induced by EtoH including focal loss of myofiber striation, degeneration, and infiltration of inflammatory cells in the cardiac tissues, as well as patchy tubular necrosis, congestion, and ectasia in renal tissues were absent in the antioxidant treated rats. Heightened immunohistochemical expressions of cardiac-specific troponin and angiotensin converting enzymes induced by EtoH were abated by alpha-tocopherol and quercetin treatment. Conclusion: Alpha-tocopherol and quercetin mitigated oxidative stress-mediated ethanol-induced derangements of the cardiovascular and renal systems in rats.

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Protective effect of exercise and alpha tocopherol on atherosclerosis promotion in hypercholesterolemic domestic rabbits

Cited by 2 publications

References 20 publications

α-Tocopherol Protects the Heart, Muscles, and Testes from Lipid Peroxidation in Growing Male Rats Subjected to Physical Efforts

α-Tocopherol Protects the Heart, Muscles, and Testes from Lipid Peroxidation in Growing Male Rats Subjected to Physical Efforts

Alpha-tocopherol and quercetin modulate primary hemodynamic parameters, oxidative stress indices, and biomarkers of cardio-renal functioning in ethanol-exposed rats

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