Protective effect of fermented aloe extract on glutamate-induced cytotoxicity in HT22 cells

Jeon, Ki Beom; Lee, Seong Hun; Kwon, Yong Seong; Beak, Jin Hong; Lee, Hyeon; Je, Choong

doi:10.1080/19768354.2022.2147584

Cited by 3 publications

(2 citation statements)

References 41 publications

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“…Although the exact pathophysiology of AD is still unclear and remains inconclusive, it is difficult to treat AD, and currently, there is no cure. A limited number of drugs are used to treat dementia, including donepezil, rivastigmine, and galantamine 15,16 . Last few decades, many clinical trials of medicine for AD treatment have failed, and it is urgent to develop a new medicine.…”

Section: Introductionmentioning

confidence: 99%

“…A limited number of drugs are used to treat dementia, including donepezil, rivastigmine, and galantamine. 15,16 Last few decades, many clinical trials of medicine for AD treatment have failed, and it is urgent to develop a new medicine. Ropinirole (ROP) is a nonergot dopamine agonist used to treat individuals with Parkinson's disease and restless leg syndrome for neurological improvements.…”

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confidence: 99%

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Neuroprotective effect of ropinirole against Aβ_1–42‐induced neurochemical perturbations and cognitive impairments in a rodent model

Akram,

Neha,

Pinky

et al. 2023

The Kaohsiung J of Med Scie

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The primary objective of this study was to investigate the protective effects of ropinirole (ROP) medication given for an extended period following the induction of cognitive decline, oxidative stress, and deterioration of mitochondria in a Wistar rat model by Aβ1–42. This study aimed to examine the neuroprotective efficacy of ROP in a stereotaxis model of AD. The Wistar rats were randomly assigned into four groups. Group I was considered as a sham, group II served as Aβ‐infusion alone, Group III was Aβ1–42+ ROP (5 mg/kg/i.p.), and Group IV was Aβ1–42+ ROP (10 mg/kg/i.p.). Our research revealed that ROP (10 mg/kg, b.wt.) attenuates the cognitive deficits caused by Aβ1–42‐infused, which also correlates with the barnes maze, where (10 mg/kg, b.w.t.) shows significant improvement in spatial learning and memory. At the same time, ROP was rescued from oxidative damage, decreased lipid peroxidation rates, and inhibited acetylcholinesterase activity caused, demonstrating antioxidant benefits. In addition, a higher dose of ROP restored mitochondrial membrane potential in Aβ1–42 rats. Furthermore, histopathological examination showed that ROP treatment reduced neuronal loss, especially in the hippocampus. We conclude that ROP's protective effects in reducing oxidative stress and modulating mitochondrial function might have a propensity in AD pathogenesis.

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Section: Introductionmentioning

confidence: 99%

mentioning

confidence: 99%

Neuroprotective effect of ropinirole against Aβ_1–42‐induced neurochemical perturbations and cognitive impairments in a rodent model

Akram,

Neha,

Pinky

et al. 2023

The Kaohsiung J of Med Scie

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Does a pickle a day keep Alzheimer's away? Fermented food in Alzheimer's disease: A review

Tyliszczak,

Wiatrak,

Danielewski

et al. 2023

Experimental Gerontology

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Chiral Amino Acids Mediate Mitochondria-Dependent Apoptosis of Human Proximal Tubular Epithelial Cells Under Oxidative Stress

Lu,

Zhang,

Jin

et al. 2024

IJMS

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Amino acids are the basic structural units of life, and their intake levels affect disease and health. In the case of renal disease, alterations in amino acid metabolism can be used not only as a clinical indicator of renal disease but also as a therapeutic strategy. However, the biological roles and molecular mechanisms of natural chiral amino acids in human proximal tubular epithelial cells (HK-2) remain unclear. In this study, cell viability assays revealed that chiral acidic amino acids (Glu and Asp) and aromatic amino acids (Trp and Phe) inhibited cell growth. The molecular mechanisms indicated that cell growth was closely related to ROS levels. Specifically, chiral Glu, Asp, Trp, and Phe induced oxidative stress and mitochondria-dependent apoptosis in HK-2 cells. This was manifested by elevated levels of intracellular ROS, 8-OHdG, and MDA, increased activities of antioxidant enzymes CAT, SOD, and GPx, decreased mitochondrial membrane potential, increased cytoplasmic Ca2+ concentration, and cell acidification. The expression levels of apoptosis-related molecules Caspase-9, Caspase-3, Cyt-C, and Bax were increased, and the expression level of anti-apoptotic molecule Bcl-2 was decreased. Moreover, L-Glu, D-Asp, L-Trp, and D-Phe exhibited a more pronounced inhibition of cell growth and elicited more substantial alterations in gene expression compared to the other configurations.

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Protective effect of fermented aloe extract on glutamate-induced cytotoxicity in HT22 cells

Cited by 3 publications

References 41 publications

Neuroprotective effect of ropinirole against Aβ_1–42‐induced neurochemical perturbations and cognitive impairments in a rodent model

Neuroprotective effect of ropinirole against Aβ_1–42‐induced neurochemical perturbations and cognitive impairments in a rodent model

Does a pickle a day keep Alzheimer's away? Fermented food in Alzheimer's disease: A review

Chiral Amino Acids Mediate Mitochondria-Dependent Apoptosis of Human Proximal Tubular Epithelial Cells Under Oxidative Stress

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Protective effect of fermented aloe extract on glutamate-induced cytotoxicity in HT22 cells

Cited by 3 publications

References 41 publications

Neuroprotective effect of ropinirole against Aβ1–42‐induced neurochemical perturbations and cognitive impairments in a rodent model

Neuroprotective effect of ropinirole against Aβ1–42‐induced neurochemical perturbations and cognitive impairments in a rodent model

Does a pickle a day keep Alzheimer's away? Fermented food in Alzheimer's disease: A review

Chiral Amino Acids Mediate Mitochondria-Dependent Apoptosis of Human Proximal Tubular Epithelial Cells Under Oxidative Stress

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Product

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Neuroprotective effect of ropinirole against Aβ_1–42‐induced neurochemical perturbations and cognitive impairments in a rodent model

Neuroprotective effect of ropinirole against Aβ_1–42‐induced neurochemical perturbations and cognitive impairments in a rodent model