Protective effect of ferulic acid on cisplatin induced nephrotoxicity in rats

Bami, Erliasa; Özakpınar, Özlem Bingöl; Ozdemir-Kumral, Zarife Nigar; Koroglu, Kutay; Ercan, Feríha; Cirakli, Zeynep; Şekerler, Turgut; İzzettin, Fikret; Sancar, Mesut; Okuyan, Betül

doi:10.1016/j.etap.2017.06.026

Cited by 76 publications

(41 citation statements)

References 48 publications

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“…FA is found in a variety of foods, including but not limited to fruits and vegetables such as pineapple, coffee beans, corn, beetroot, grains such as wheat, barley, bran, and legumes such as navy beans and horse grams (Harris & Hartley, ; Hartley & Harris, ; Quinde‐Axtell & Baik, ). It has shown promising effects against cytotoxicity (Bami et al, ), neuroinflammation (Liu et al, ), and even some skin whitening and anti‐wrinkle properties when applied topically (Park et al, ). In a study on cardiotoxicity, FA attenuated mitochondrial changes such as decreased activity of respiratory chain enzymes and antioxidants and increased mitochondrial lipid peroxidation (Yogeeta, Raghavendran, Gnanapragasam, Subhashini, & Devaki, ).…”

Section: Introductionmentioning

confidence: 99%

Ferulic acid reinstates mitochondrial dynamics through PGC1α expression modulation in 6‐hydroxydopamine lesioned rats

Anis

Zafeer

Firdaus

et al. 2019

Phytotherapy Research

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Disruption of the tightly regulated mitochondrial dynamics and energy homeostasis leads to oxidative stress and apoptotic cell death, as observed in neurodegenerative disorders such as Parkinson's disease (PD). Polyphenolic plant derivatives have been shown to alleviate such pathological features and have been used in models of neurodegenerative disorders in previous reports. In the current study, we utilized a 6hydroxydopamine (6-OHDA) lesioned rat model of PD to explore the protective efficacy of polyphenolic phytochemical ferulic acid (FA) against mitochondrial dysfunction and explored its effect on gene and protein expression of mitochondrial dynamics regulators dynamin-related protein 1 (Drp1)/mitofusin 2 (Mfn2) in lesioned animals. We also evaluated its effect on expression of mitochondrial biogenesis regulator PGC1α and apoptotic regulators BAX, cyt c, p53, and cleaved PARP. We found that oral FA supplementation alleviated 6-OHDA induced oxidative stress, DNA fragmentation, morphological changes, and blocked apoptotic cascade. FA also reduced mitochondrial Drp1 expression and increased gene and protein expression of PGC1α, thereby regulating expression of its downstream target Mfn2 and restoring mitochondrial dynamics in lesioned animals. Our data suggest that targeting mitochondrial dynamics through modulation of PGC1α can prove to be a potent preventive strategy against PD pathology.

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Section: Introductionmentioning

confidence: 99%

Ferulic acid reinstates mitochondrial dynamics through PGC1α expression modulation in 6‐hydroxydopamine lesioned rats

Anis

Zafeer

Firdaus

et al. 2019

Phytotherapy Research

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“…However, the molecular mechanism of CIS testicular toxicity is currently unclear. Nevertheless, previous systematic investigations have persistently implicated oxidative stress, inflammation and mitochondrial caspase-dependent apoptosis as mechanisms for CIS toxicity (Al-Malki & Sayed, 2014;Bami et al, 2017;Ko et al, 2019).…”

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confidence: 99%

Ginger juice prevents cisplatin‐induced oxidative stress, endocrine imbalance and NO/iNOS/NF‐κB signalling via modulating testicular redox‐inflammatory mechanism in rats

Famurewa¹,

Ekeleme‐Egedigwe²,

Onwe

et al. 2020

Andrologia

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Chemotherapy is a cornerstone option in cancer treatment owing to its efficacy and effect on quality of life of cancer patients. The action mechanism of anticancer agents is targeted at deregulating cell cycle machinery and inhibiting unscheduled proliferation of cancer cells (Lin et al., 2020). Unfortunately, chemotherapeutic anticancer drugs often exert deleterious effect on healthy cells and tissues leading to systemic toxicity (Negrette-Guzmán, 2019). The toxicity may become unbearable that the treatment regimen has to be disrupted, even when achieving tumoricidal efficacy (Lin et al., 2020). Cisplatin (CIS) is an efficacious anticancer agent; it is the first choice for the treatment of advanced nonsmall-cell lung cancer cells, breast cancer and ovarian cancer (Browning et al., 2017; Lin et al., 2020; Manohar & Leung, 2018). It is of significant value also in the treatment of germ cell and testicular cancers (Thurston, 2007). It unleashes its anticancer action through formation of cisplatin-DNA adduct by intrastrand cross-links due to interaction with cancer cell DNA purine bases eventually leading to p53 activation, cell cycle arrest and induction

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“…168,171 FeA-mediated HO-1 upregulation reappeared as a protective mechanism against cisplatin-induced nephrotoxicity in rats. 169 In another study in rats with gentamicin-induced nephrotoxicity, FeA increased superoxide dismutase, glutathione peroxidase and catalase, and consequently reduced the nephrotoxicity of gentamicin. 170 Finally, in a very recent study, FeA was shown to prevent lead-induced testicular oxidative stress in rats via possibly inhibiting lipid peroxidation and enhancing antioxidant defense systems.…”

Section: Caffeic Acid: Recent Advancesmentioning

confidence: 97%

“…Like CaA, FeA protected against chemically induced acute liver damage and lipopolysaccharide‐induced acute kidney injuries in mice via reducing the oxidative damage and inflammatory signaling pathways . FeA‐mediated HO‐1 upregulation reappeared as a protective mechanism against cisplatin‐induced nephrotoxicity in rats . In another study in rats with gentamicin‐induced nephrotoxicity, FeA increased superoxide dismutase, glutathione peroxidase and catalase, and consequently reduced the nephrotoxicity of gentamicin .…”

Section: Mechanism Of Action Of Hydroxycinnamic Acids: Recent Advancesmentioning

confidence: 98%

“…135 Ferulic acid: recent advances The antioxidant, antihyperlipidemic, antidiabetic, antimicrobial, anti-inflammatory, antiatherogenic, anticarcinogenic, neuroprotective and antihypertensive properties of FeA have been extensively investigated and summarized in numerous reviews. 40,41,45,46,[139][140][141] Recent pre-clinical studies in rodents have focused mainly on therapies for Alzheimer's disease and other brain disfunctions, [142][143][144][145][146][147][148][149][150][151] obesity and diabetes, [152][153][154][155][156][157][158][159][160][161][162][163][164] skin cancer, [165][166][167] liver and kidney injuries, [168][169][170][171] and testicular oxidative stress 172 (Table 5).…”

Section: Caffeic Acid: Recent Advancesmentioning

confidence: 99%

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Hydroxycinnamic acids and human health: recent advances

2019

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There is an urgent need to improve human diet globally. Compelling evidence gathered over the past several decades suggests that a suboptimal diet is associated with many chronic diseases and may be responsible for more deaths than any other risks worldwide. The main components in our diet that need higher intake are whole grains, fruit and vegetables, and nuts and seeds; all of these are important sources of dietary fiber and polyphenols. The health benefits of dietary fiber and polyphenols are also supported by several decades of valuable research. However, the conclusions drawn from interventional human trials are not straightforward and the action mechanisms in improving human health are not fully understood. Moreover, there is a great inter‐individual variation caused by different individual capabilities of processing, absorbing and using these compounds effectively. Data on the bioavailability and bioefficacy of hydroxycinnamic acids (HCAs) are limited when compared to other classes of polyphenols (e.g. anthocyanins). This review aims to summarize the latest research advances related to HCA bioavailability and their biological effects revealed by epidemiological data, pre‐clinical and clinical studies. Moreover, we aim to review the effects of HCAs on gut microbiota diversity and function and its respective influence on host health. © 2019 Society of Chemical Industry

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Protective effect of ferulic acid on cisplatin induced nephrotoxicity in rats

Cited by 76 publications

References 48 publications

Ferulic acid reinstates mitochondrial dynamics through PGC1α expression modulation in 6‐hydroxydopamine lesioned rats

Ferulic acid reinstates mitochondrial dynamics through PGC1α expression modulation in 6‐hydroxydopamine lesioned rats

Ginger juice prevents cisplatin‐induced oxidative stress, endocrine imbalance and NO/iNOS/NF‐κB signalling via modulating testicular redox‐inflammatory mechanism in rats

Hydroxycinnamic acids and human health: recent advances

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