Protective effect of ginger against toxicity induced by chromate in rats

Krim, Meriem; Messaadia, Amira; Maidi, Imen; Aouacheri, O.; Saka, S.

doi:10.1684/abc.2013.0806

Cited by 16 publications

(10 citation statements)

References 51 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This may be due to the impairment in their synthesis or poor liver function associated to oxidative stress [41]. Similar results were observed by Abbas and Ali, Zhu et al, Mehany et al, Mohamed and Saber, Saha et al, and Krim et al [31,42,43,44,45,46] in rats treated with potassium dichromate.…”

Section: Discussionsupporting

confidence: 61%

Oxidative Effects of Potassium Dichromate on Biochemical, Hematological Characteristics, and Hormonal Levels in Rabbit Doe (Oryctolagus cuniculus)

Momo

Ferdinand

Bebe

et al. 2019

Veterinary Sciences

View full text Add to dashboard Cite

The present study was conducted to evaluate the toxicity induced by the increasing doses of potassium dichromate in rabbit doe. Twenty-eight adult does of 6 months of age were divided into four groups (A, B, C, and D; n = 7), with comparable average body weight (bw). Group A rabbits received only distilled water daily and served as a control, while groups B, C, and D received, respectively, 10 mg/kg bw, 20 mg/ kg bw, and 40 mg/kg bw of potassium dichromate via gavage for 28 days, after which animals were anesthetized with ether vapor and sacrificed. Blood samples were obtained via cardiac puncture and collected without anticoagulant for biochemical dosages and with anticoagulant (EDTA) for complete blood count. Follicle stimulating hormone (FSH), luteinizing hormone (LH), and estradiol (E2) were dosed in serum and in homogenates of ovary with the help of AccuDiagTM ELISA kits from OMEGA DIAGNOSTICS LTD (Scotland, England) while respecting the immuno-enzymatic method. Activities of superoxide dismutase (SOD), glutathione (GSH), catalase (CAT), and concentration of malondialdehyde (MDA) in liver, kidney, ovary and uterus were measured. Hematology revealed a significant (p < 0.05) decrease in mean values of hemoglobin and platelets while white blood cells and lymphocytes showed a significant (p < 0.05) increase in exposed groups. No significant (p > 0.05) difference was registered in monocytes, red blood cells, hematocrits, and plaquetocrits values with respect to the control. No matter the organ considered, no significant (p > 0.05) change was recorded in weight and volume. Nephrotoxicity analysis registered a significant (p < 0.05) increase in urea and creatinine, unlike renal tissue protein, which decreased significantly (p < 0.05). However, hepatotoxicity registered no significant (p > 0.05) variation in aspartate aminotransferase but total protein, alanine aminotransferase, and total cholesterol increased significantly (p < 0.05), while hepatic tissue protein revealed a significant (p < 0.05) decrease. Analysis on reproductive parameters showed a significant (p < 0.05) decrease in ovarian and uterine tissue proteins, as well as in follicle stimulating hormone, luteinizing hormone, and estradiol. Oxidative stress markers recorded no significant (p > 0.05) difference in glutathione reductase except in ovary where a significant (p < 0.05) decrease was seen when compared with the control, while catalase revealed a significant (p < 0.05) decrease, except in liver where there was no significant (p > 0.05) change. Superoxide dismutase and malondialdehyde recorded a significant (p < 0.05) decrease and increase respectively, with respect to the control. Results obtained from this study showed that the reduction process of chromium in tissues may cause the generation of reactive oxygen species, which are involved in hematoxic, nephrotoxic, hepatotoxic, and reproductive toxicity effects.

show abstract

Section: Discussionsupporting

confidence: 61%

Oxidative Effects of Potassium Dichromate on Biochemical, Hematological Characteristics, and Hormonal Levels in Rabbit Doe (Oryctolagus cuniculus)

Momo

Ferdinand

Bebe

et al. 2019

Veterinary Sciences

View full text Add to dashboard Cite

show abstract

“…Moreover, administration of ginger revealed a reduction of the intensity of oxidative stress induced by Cr(VI), demonstrating that ginger has potent antioxidant activity toward Cr(VI)-induced damage. 98 …”

Section: Chromium-carcinogenicity Chemopreventionmentioning

confidence: 99%

Carcinogenicity of chromium and chemoprevention: a brief update

Song

et al. 2017

OTT

206

103

View full text Add to dashboard Cite

Chromium has two main valence states: hexavalent chromium (Cr[VI]) and trivalent chromium (Cr[III]). Cr(VI), a well-established human carcinogen, can enter cells by way of a sulfate/phosphate anion-transport system, and then be reduced to lower-valence intermediates consisting of pentavalent chromium (Cr[V]), tetravalent chromium (Cr[IV]) or Cr(III) via cellular reductants. These intermediates may directly or indirectly result in DNA damage or DNA–protein cross-links. Although Cr(III) complexes cannot pass easily through cell membranes, they have the ability to accumulate around cells to induce cell-surface morphological alteration and result in cell-membrane lipid injuries via disruption of cellular functions and integrity, and finally to cause DNA damage. In recent years, more research, including in vitro, in vivo, and epidemiological studies, has been conducted to evaluate the genotoxicity/carcinogenicity induced by Cr(VI) and/or Cr(III) compounds. At the same time, various therapeutic agents, especially antioxidants, have been explored through in vitro and in vivo studies for preventing chromium-induced genotoxicity/carcinogenesis. This review aims to provide a brief update on the carcinogenicity of Cr(VI) and Cr(III) and chemoprevention with different antioxidants.

show abstract

“…This hepatomegaly can be explained by the over-espression of oxidative stress and over-excitation of the liver detoxification process in response to the harmful effect of xenobiotics (Guerriero et al, 2014;Abdel-Gawad et al, 2020).Furthermore, blood glucose level was significantly increased in treated rats compared with controls, and this concords with those previously reported (Azzez et al, 2011;Delgadoa et al,2018).The hyperglycemia due to calcium nitrate treatment is likely explained by the activation of the glycogenolysis process, resulting in the release of glucose by glycogen phosphorylase under the action of amylase (Hijmans et al, 2014).Several European research studies have attempted to discover a close association between nitrate concentration in drinking water and insulin-dependent diabetes by increasing blood glucose while decreasing hepatic glycogen (IDD), but the comparison revealed sparse and contradictory data (Moltchanova et al,2004).On the other hand, results showed a very highly significant increase in the levels of cholesterol and triglycerides. This hyperlipidemia can be explained by hypothyroidism (Jublanc and Bruckert, 2004;Pearce, 2004).Previous in vivo experimental studies have proven that inorganic nitrate is a short-term goitrogenic agent causing hypertrophy of the epithelial cells of the thyroid gland (Boukerche et al, 2007;Gatseva and Argirova, 2008;Messaadia et al, 2013).On top of that, (Ca (NO 3 ) 2 4H 2 O) treated rats for 30 days resulted in an elevation of enzymatic activity of transaminases (AST, ALT) and alkaline phosphatase (ALP) and bilirubin level, and a lowering of total protein and albumin levels. This result is in line with that previously reported (Messaadia et al, 2013;Fouad et al, 2017;Kattiaa et al, 2017).…”

Section: Discussionmentioning

confidence: 99%

Untitled

2023

JJBS

View full text Add to dashboard Cite

Study areas include cell biology, genomics, microbiology, immunology, molecular biology, biochemistry, embryology, immunogenetics, cell and tissue culture, molecular ecology, genetic engineering and biological engineering, bioremediation and biodegradation, bioinformatics, biotechnology regulations, gene therapy, organismal biology, microbial and environmental biotechnology, marine sciences. The JJBS welcomes the submission of manuscript that meets the general criteria of significance and academic excellence. All articles published in JJBS are peerreviewed. Papers will be published approximately one to two months after acceptance.

show abstract

Protective effect of ginger against toxicity induced by chromate in rats

Abstract: Protective effect of ginger against toxicity induced by chromate in rats Effet protecteur du gingembre contre la toxicité induite par le chromate chez les rats

Cited by 16 publications

References 51 publications

Oxidative Effects of Potassium Dichromate on Biochemical, Hematological Characteristics, and Hormonal Levels in Rabbit Doe (Oryctolagus cuniculus)

Oxidative Effects of Potassium Dichromate on Biochemical, Hematological Characteristics, and Hormonal Levels in Rabbit Doe (Oryctolagus cuniculus)

Carcinogenicity of chromium and chemoprevention: a brief update

Untitled

Contact Info

Product

Resources

About