Protective effect of glucosamine on zearalenone-induced reproductive toxicity and placental dysfunction in mice

Bai, Jun; Hai, Jian; Zhai, Zhian; Li, Jun; Song, Zhuan; Yang, Qing; Fazhen, Ren; Wu, Zhenlong

doi:10.1016/j.fct.2022.113539

Cited by 9 publications

(6 citation statements)

References 50 publications

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“…38 However, how ZEN reduces food intake in animals is not clear. 6,7 In this study, we found that ZEN disrupted BA homeostasis and increased the total BA concentrations. The increase in total BA concentrations was negatively correlated with a decrease in food intake, which was consistent with the findings of another study, where elevated BA concentrations were reported to decrease food intake.…”

Section: ■ Discussionsupporting

confidence: 51%

“…In animal husbandry, food intake is a reliable indicator of production performance, and a decrease in food intake is a sensitive indicator that reflects the health status of the body . However, how ZEN reduces food intake in animals is not clear. , In this study, we found that ZEN disrupted BA homeostasis and increased the total BA concentrations. The increase in total BA concentrations was negatively correlated with a decrease in food intake, which was consistent with the findings of another study, where elevated BA concentrations were reported to decrease food intake. ,, A correlation analysis between food intake and BA concentrations was conducted.…”

Section: Discussionmentioning

confidence: 52%

Section: ■ Introductionmentioning

confidence: 99%

“…Food intake is an important indicator of animal performance and acts as a sensitive indicator of health status. Although several studies have reported that ZEN can reduce food intake, , none have elucidated its underlying mechanism of action. Recent research studies have reported that BAs in the hypothalamus can cause anorexigenic effects by activating the G-protein-coupled BA receptor (TGR5). , BAs also strongly regulate the secretion of appetite-related hormones by activating basolateral intestinal TGR5. , Additionally, due to the differences in estrogen levels between males and females, they may respond differently to ZEN.…”

Section: Introductionmentioning

confidence: 99%

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Zearalenone Decreases Food Intake by Disrupting the Gut–Liver–Hypothalamus Axis Signaling via Bile Acids

Yuan,

Ma,

et al. 2024

J. Agric. Food Chem.

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Zearalenone (ZEN) is a mycotoxin that is harmful to humans and animals. In this study, female and male rats were exposed to ZEN, and the results showed that ZEN reduced the farnesoid X receptor (FXR) expression levels in the liver and disrupted the enterohepatic circulation of bile acids (BAs). A decrease in food intake induced by ZEN was negatively correlated with an increase in the level of total BAs. BA-targeted metabolomics revealed that ZEN increased glycochenodeoxycholic acid levels and decreased the ratio of conjugated BAs to unconjugated BAs, which further increased the hypothalamic FXR expression levels. Preventing the increase in total BA levels induced by ZEN via Lactobacillus rhamnosus GG intervention restored the appetite. In conclusion, ZEN disrupted the enterohepatic circulation of BAs to decrease the level of food intake. This study reveals a possible mechanism by which ZEN affects food intake and provides a new approach to decrease the toxic effects of ZEN.

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Section: ■ Discussionsupporting

confidence: 51%

Section: Discussionmentioning

confidence: 52%

Section: ■ Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Zearalenone Decreases Food Intake by Disrupting the Gut–Liver–Hypothalamus Axis Signaling via Bile Acids

Yuan,

Ma,

et al. 2024

J. Agric. Food Chem.

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“…Many studies have indicated the potential of various compounds such as lycopene [ 10 ], selenium [ 9 ], vitamin C [ 11 ], curcumin [ 12 ], procyanidins [ 13 ], and glucosamine [ 14 ] in preventing ZEN-induced reproductive toxicities. Among these, rutin (RUT), recognized as rutinoside, quercetin-3-O-rutin, is a prevalent flavonoid found abundantly in fruits and vegetables.…”

Section: Introductionmentioning

confidence: 99%

Alleviative Effect of Rutin on Zearalenone-Induced Reproductive Toxicity in Male Mice by Preventing Spermatogenic Cell Apoptosis and Modulating Gene Expression in the Hypothalamic–Pituitary–Gonadal Axis

Sayed,

Zhang,

Tang

et al. 2024

Toxins

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Zearalenone (ZEN) is a non-steroidal estrogenic mycotoxin found in many agricultural products and can cause reproductive disorders, mainly affecting spermatogenesis in male animals. Rutin (RUT) is a natural flavonoid compound recognized for its significant antioxidant, anti-inflammatory and estrogenic properties. The present study aimed to determine the protective role of RUT against ZEN-induced reproductive toxicity in male mice. Twenty-four adult Kunming male mice were divided into four groups: control, RUT (500 mg/kg RUT), ZEN (10 mg/kg ZEN), ZEN + RUT (500 mg/kg RUT + 10 mg/kg ZEN), with six replicates per treatment. The results indicated that RUT mitigated ZEN-induced disruption in spermatogenic cell arrangement, decreased spermatozoa count, and increased sperm mortality in the testes. RUT significantly restored ZEN-induced reduction in T, FSH, LH, and E2 serum levels. Moreover, RUT mitigated ZEN-induced apoptosis by increasing the mRNA expression level of bcl-2, decreasing the mRNA expression level of kiss1-r, and decreasing the protein expression level of caspase 8 in reproductive tissues. These findings indicate the protective role of RUT against ZEN-induced reproductive toxicity in male mice by regulating gonadotropin and testosterone secretions to maintain normal spermatogenesis via the HPG axis, which may provide a new application direction for RUT as a therapeutic agent to mitigate ZEN-induced reproductive toxicity.

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Electrochemical aptasensor based on CRISPR/Cas12a-mediated and DNAzyme-assisted cascade dual-enzyme transformation strategy for zearalenone detection

Yan,

He,

Zhao

et al. 2024

Chemical Engineering Journal

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Protective effect of glucosamine on zearalenone-induced reproductive toxicity and placental dysfunction in mice

Cited by 9 publications

References 50 publications

Zearalenone Decreases Food Intake by Disrupting the Gut–Liver–Hypothalamus Axis Signaling via Bile Acids

Zearalenone Decreases Food Intake by Disrupting the Gut–Liver–Hypothalamus Axis Signaling via Bile Acids

Alleviative Effect of Rutin on Zearalenone-Induced Reproductive Toxicity in Male Mice by Preventing Spermatogenic Cell Apoptosis and Modulating Gene Expression in the Hypothalamic–Pituitary–Gonadal Axis

Electrochemical aptasensor based on CRISPR/Cas12a-mediated and DNAzyme-assisted cascade dual-enzyme transformation strategy for zearalenone detection

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