Protective Effect of Green Tea (<i>Camellia sinensis</i> (L.) Kuntze) against Prostate Cancer: From In Vitro Data to Algerian Patients

Lassed, Somia; Deus, Cláudia M.; Djebbari, Radja; Zama, Djamila; Oliveira, Paulo J.; Rizvanov, Albert A.; Dahdouh, Abderrezak; Benayache, Fadila

doi:10.1155/2017/1691568

Cited by 20 publications

(11 citation statements)

References 52 publications

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“…In a recent case-control involving Vietnamese men, increasing tea consumption (>500 ml/day) was found to be associated with decreased risk of prostate cancer [84]. Similar findings were reported in a case-control study of Algerian men, although the results were borderline statistically [80]. In one of the first clinical Dietary Antioxidants in the Chemoprevention of Prostate Cancer DOI: http://dx.doi.org /10.5772/intechopen.85770 studies to examine the effect of polyphenols (from green tea) on prostate cancer, Betuzzi and colleagues showed that green tea consumption reduces the incidence of prostate cancer in men with high-grade prostate intraepithelial neoplasia (HGPIN).…”

Section: Green Teasupporting

confidence: 73%

“…Green tea (GT) is one of the most widely studied source of phenolic acids such epigallocatechin-3-gallate (EGCG), epicatechin-3-gallate (ECG), and epicatechin (EC). There are a number of studies that have investigated the relationship between risk of prostate cancer and green tea [78][79][80][81][82], and preclinical, clinical, and epidemiological data suggest that green tea catechins may reduce prostate cancer risk [83]. In a recent case-control study of Chinese men, epigallocatechin 3-gallate and green tea reduced the risk of prostate cancer; however, the authors indicated that these results should be replicated in larger cohort or case-control studies [84].…”

Section: Green Teamentioning

confidence: 99%

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Dietary Antioxidants in the Chemoprevention of Prostate Cancer

Tucker¹,

Anderson²,

Miller³

et al. 2019

Antioxidants

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Prostate cancer is the second most common cancer and the fifth leading cause of cancer death. The incidence of prostate cancer is rising due to increased screening and awareness, and there is epidemiological evidence suggesting an interaction among biological and environmental risk factors in the development and progression of prostate cancer. Vegetables and fruits provide a wide range of antioxidants and phytochemicals that have been demonstrated to have a negative, positive, or no association with prostate cancer risk. Therefore, it is evident that the effect of dietary antioxidants on risk of prostate cancer remains undecided and inconclusive. The main focus of this review was to examine recent and past literature of the chemoprotective properties of five major groups of phytochemicals against prostate cancer development including both in vivo and in vitro findings. 2 oxidative stress from reactive oxygen species and loss of antioxidant enzymes may contribute to genomic instability prior to prostate cancer [9]. This paper will review information in the literature on the relationship between nutrients with antioxidant properties from the diet, and the risk of prostate cancer. Method of article selectionA literature search was conducted for all English language literature published before December 2018. The search was conducted using the electronic databases, including PubMed, Embase, Web of Science, and Cochrane Library. The search strategy included keywords such as prostate cancer, epidemiology, incidence, mortality, risk factor, selenium, vitamin E, vitamin C, carotenoids, and polyphenols.The authors include many interventional and observational studies that have reported findings of dietary antioxidants, prostate cancer incidence, and progression. The majority of these studies focused on vitamins E and C, carotenoids, specifically beta-and alpha-carotene and lycopene, phenols including tea and coffee, and the flavonoids, as well as selenium.

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Section: Green Teasupporting

confidence: 73%

Section: Green Teamentioning

confidence: 99%

Dietary Antioxidants in the Chemoprevention of Prostate Cancer

Tucker¹,

Anderson²,

Miller³

et al. 2019

Antioxidants

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“…In a previous study, the authors showed that green tea inhibited proliferation and also induced apoptosis in 4TI metastatic breast cancer cells (6) The authors have shown in a study that green tea can regulate the antioxidant capacity in people exposed to oxidative stress (25). Besides, C. sinensis decreased oxidative stress in patients with prostate cancer (26). In a study, it was suggested that green tea showed protective effects through its antioxidant properties against oxidative stress and DNA damages, (27).…”

Section: Discussionmentioning

confidence: 99%

“…Oxidative damage can be cured with phytochemicals found in tea in diseases such as cancer (15,22). Healing properties of C. sinensis have been investigated in many types of cancers such as metastatic breast (6), human ovarian 7, lung (23), and prostate cancers (8). The effects of C. sinensis were investigated in pancreatic carcinoma cells (9,24).…”

Section: Discussionmentioning

confidence: 99%

“…Furthermore, the protective effects of C. sinensis were demonstrated in different types of cancers such as breast, ovarian, prostate and pancreatic cancers. The importance of anti-cancer activity of tea was highlighted (6)(7)(8)(9) In the current study, the effects of the extract from C. sinensis on cytotoxicity, proliferation, apoptosis and oxidative stress status were investigated in rat insulinoma INS-1 cells.…”

Section: Introductionmentioning

confidence: 97%

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The Effects of Camellia sinensis Extract on Proliferation, Apoptosis and Oxidative Stress in Insulinoma INS-1 Cells

Kaçar¹,

Ersöz²,

SEZEKLER³

et al. 2019

Bezmialem Science

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Objective: Green tea (Camellia sinensis) is one of the most consumed beverages in the world. C. sinensis consumption may prevent tumor and other diseases. Insulinomas are pancreatic islet cell tumors. In present study, the effects of the extract from C. sinensis were investigated in rat insulinoma INS-1 cells. Methods: C. sinensis leaves were collected in Rize, Turkey. The leaves were brewed in tap water for 20 and 40 minutes at 80°C. INS-1 cells were treated with different doses (1-5 mg/mL) of C. sinensis extract for 24 h. Cell viability, proliferation, death were examined. The malondialdehyde, glutathione and protein carbonyl levels were measured in INS-1 cells given C. sinensis extract. Results: The cell viability and the percentage of proliferating cell nuclear antigen immunopositive cells decreased, while the percentage of TUNEL positive cells increased in INS-1 cells treated with the extract from C. sinensis according to control group. While malondialdehyde and protein carbonyl levels in INS-1 cells treated with C. sinensis extract decreased, glutathione levels increased according to control group. Conclusion: The results indicate that the extracts from C. sinensis inhibited proliferation and caused apoptosis in INS-1 cell. C. sinensis may be natural agent for supporting the treatment of pancreatic tumors.

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Dietary plants for oral cancer prevention and therapy: A review of preclinical and clinical studies

Bishayee,

Penn,

Bhandari

et al. 2024

Phytotherapy Research

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Oral cancer is a disease with high mortality and rising incidence worldwide. Although fragmentary literature on the anti‐oral cancer effects of plant products has been published, a comprehensive analysis is lacking. In this work, a critical and comprehensive evaluation of oral cancer preventative or therapeutic effects of dietary plants was conducted. An exhaustive analysis of available data supports that numerous dietary plants exert anticancer effects, including suppression of cell proliferation, viability, autophagy, angiogenesis, invasion, and metastasis while promoting cell cycle arrest and apoptosis. Plant extracts and products target several cellular mechanisms, such as the reversal of epithelial‐to‐mesenchymal transition and the promotion of oxidative stress and mitochondrial membrane dysfunction by modulation of various signaling pathways. These agents were also found to regulate cellular growth signaling pathways by action on extracellular signal‐regulated kinase and mitogen‐activated protein kinase, inflammation via modulation of cyclooxygenase (COX)‐1, COX‐2, and nuclear factor‐κB p65, and metastasis through influence of cadherins and matrix metalloproteinases. In vivo studies support these findings and demonstrate a decrease in tumor burden, incidence, and hyperplastic and dysplastic changes. Clinical studies also showed decreased oral cancer risk. However, high‐quality studies should be conducted to establish the clinical efficacy of these plants. Overall, our study supports the use of dietary plants, especially garlic, green tea, longan, peppermint, purple carrot, saffron, tomato, and turmeric, for oral cancer prevention and intervention. However, further research is required before clinical application of this strategy.

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Protective Effect of Green Tea (Camellia sinensis (L.) Kuntze) against Prostate Cancer: From In Vitro Data to Algerian Patients

Cited by 20 publications

References 52 publications

Dietary Antioxidants in the Chemoprevention of Prostate Cancer

Dietary Antioxidants in the Chemoprevention of Prostate Cancer

The Effects of Camellia sinensis Extract on Proliferation, Apoptosis and Oxidative Stress in Insulinoma INS-1 Cells

Dietary plants for oral cancer prevention and therapy: A review of preclinical and clinical studies

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