Protective Effect of Hemin Against Experimental Chronic Fatigue Syndrome in Mice: Possible Role of Neurotransmitters

Thakur, Vandana; Jamwal, Sumit; Kumar, Mandeep; Rahi, Vikrant; Kumar, Puneet

doi:10.1007/s12640-020-00231-y

Cited by 8 publications

(6 citation statements)

References 34 publications

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“…Excessive and intensive exercise practice can lead to muscle fatigue in humans (5). Several studies are striving to find a promising antifatigue agent for exercise-induced fatigue syndrome (6)(7)(8).…”

Section: Introductionmentioning

confidence: 99%

The anti-fatigue potential of water-soluble polysaccharides of Semen cassiae on BALB/c mice

Kang

Liu

Chi

et al. 2021

Cell Mol Biol (Noisy-le-grand)

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Fatigue syndrome is a major health problem that affects the voluntary activities of an individual. Particularly, exercise-induced fatigue has become a serious concern in people's health. Since polysaccharides from various medicinal plants have been reported for anti-fatigue effect, the current study deals with the anti-fatigue potential of water-soluble polysaccharides of the Chinese medicinal plant Semen cassiae (Cassia obtusifolia L.) in BALB/c mice. Water-soluble polysaccharides from Semen cassiae were extracted using aqueous solvent (water). An orthogonal test design was employed for the optimization of polysaccharide extraction. The conditions optimized through this design unveiled the raw materials to solvent ratio as 1:30. The optimal temperature and time duration were found to be 80°C and 3.5 h, respectively. The yield of soluble polysaccharides at these specified conditions was 5.42%. Strikingly, the water-soluble polysaccharide from S. cassiae exhibited strong anti-fatigue activity at 100 mg/kg in BALB/c mice. S. cassiae polysaccharide extended the weight-loaded swimming duration in BALB/c mice. In addition, it ameliorated the level of antioxidant enzymes (SOD, GPX) while decreased the blood urea nitrogen, creatine phosphokinase, triglyceride, lactic acid, lactate dehydrogenase, and malondialdehyde levels in blood serum. Moreover, the assessment of the immunomodulatory effect of S. cassia polysaccharides unveiled the enhancement of B-cell and T-cell lymphocytes, denoting the positive effect on physical immunity.

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Section: Introductionmentioning

confidence: 99%

The anti-fatigue potential of water-soluble polysaccharides of Semen cassiae on BALB/c mice

Kang

Liu

Chi

et al. 2021

Cell Mol Biol (Noisy-le-grand)

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“…Dopaminergic processes were the only processes to feature in the results for the GO enrichment analysis of all hub types. The fatigue in ME/CFS seems likely to be partially dopaminergic centrally, considering the efficacy of multiple dopaminergic agents in ME/CFS (Blockmans et al, 2006;Blockmans and Persoons, 2016;Crosby et al, 2021;Goodnick et al, 1992;Kaiser, 2015), and in mouse models of ME/CFS (Song et al, 2021;Thakur et al, 2020). This would also fit with the high rates of Attention Deficit Hyperactivity Disorder (ADHD) in ME/CFS (Sáez-Francàs et al, 2012), and monoamine metabolite levels in cerebrospinal fluid (Demitrack et al, 1992).…”

Section: Dopaminementioning

confidence: 98%

A Cartography of Differential Gene Methylation in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: Different Network Roles in the Protein-Protein Interactions Network Play Different, Biologically Relevant, Roles

Wilberforce

Riva

2021

Preprint

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Myalgic Encephalomyelitis, also known as Chronic Fatigue Syndrome (ME/CFS), is a debilitating illness characterised by severe fatigue and associated with immune dysfunction. Previous studies of DNA methylation (epigenetic changes that can affect the gene transcription) have found evidence of changes in immune cells for ME/CFS. However these studies have been limited by their small sample size, precluding the ability to detect changes to methylation of smaller magnitude. Therefore, to achieve a larger sample size and detect small changes to DNA methylation, we aggregate three comparable datasets and analyse them in unison. We find 10,824 differentially methylated genes, with a very small average change. We then turn our attention to the network structure of the Protein-Protein interaction, which we built from the currently known interactions of relevant proteins, and localising the network cartography framework, we identify 184 hub genes. A distinct structuring emerges, with different hub types playing differing, meaningful, biological roles. Supporting previous theories about ME/CFS, Gene ontology enrichment analysis of these hubs reveal that they are involved in immune system processes, including response to TGF-β and LPS, as well as mitochondrial functioning. We also show that dopaminergic signalling may potentially contribute to immune pathology in ME/CFS. Our results demonstrate the potentiality of network cartographic approaches in shedding light on the epigenetic contribution to the immune dysregulation of ME/CFS.

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“…The average value was used for statistical purposes. 14 2.5.3. Fatigue-related biochemical indicators.…”

Section: Papermentioning

confidence: 99%

“…Studies have confirmed that various neurotransmitters, including DA, 5-HT, and NE, have been linked to the generation of fatigue and emotion regulation. 14,43 Increased expression of 5-HT and 5-HT1A is closely associated with fatigue and mood changes such as depression. 5-HT is a key substance in nervous system regulation, whose level is proportional to the degree of central weariness.…”

Section: Papermentioning

confidence: 99%

Effects ofDendrobium officinaleultrafine powder on sub-health mice induced by unhealthy lifestyle based on neuroendocrine immune system

et al. 2022

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Protective Effect of Hemin Against Experimental Chronic Fatigue Syndrome in Mice: Possible Role of Neurotransmitters

Cited by 8 publications

References 34 publications

The anti-fatigue potential of water-soluble polysaccharides of Semen cassiae on BALB/c mice

The anti-fatigue potential of water-soluble polysaccharides of Semen cassiae on BALB/c mice

A Cartography of Differential Gene Methylation in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: Different Network Roles in the Protein-Protein Interactions Network Play Different, Biologically Relevant, Roles

Effects ofDendrobium officinaleultrafine powder on sub-health mice induced by unhealthy lifestyle based on neuroendocrine immune system

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