Protective effect of herbal medicine Huangqi decoction against chronic cholestatic liver injury by inhibiting bile acid-stimulated inflammation in DDC-induced mice

Li, Wenkai; Wang, Guofeng; Wang, Tianming; Li, Yuanyuan; Li, Yifei; Lu, Xinyi; Wang, Yahang; Zhang, Hua; Liu, Ping; Wu, Jiasheng; Ma, Yueming

doi:10.1016/j.phymed.2019.152948

Cited by 47 publications

(27 citation statements)

References 40 publications

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“…However, UDCA is used for early PBC and one‐third of affected patients show no response to it. OCA is used for patients who do not respond to UDCA, but its administration is accompanied by severe itching (Li et al, 2019). While the current medicine is gradually being recognized as insufficient to achieve the desired goals in the treatment of progressive diseases, traditional Chinese medicine can make valid improvements in these diseases.…”

Section: Introductionmentioning

confidence: 99%

Preclinical evidence of Yinchenhao decoction on cholestasis: A systematic review and meta‐analysisof animal studies

Shi

Wen

Zeng

et al. 2020

Phytotherapy Research

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Cholestasis is an important cause of liver fibrosis and cirrhosis. Yinchenhao decoction has been used as a well‐known traditional Chinese medicine used in the treatment of cholestasis for over 2,000 years. The purpose of this systematic review is to evaluate the preclinical evidence of Yinchenhao decoction on cholestasis models. The following databases were searched from inception to February 2020. Chinese National Knowledge Infrastructure, VIP medicine information system, Wanfang Database, PubMed, Web of Science, Embase and the Cochrane Library were searched. The content concerned Yinchenhao decoction on different animal model experiments for the treatment of cholestasis. The methodological quality of the included studies was assessed based on the SYstematic Review Center for Laboratory animal Experimentation Animal Experiment Bias Risk Assessment Tool. A meta‐analysis was conducted with RevMan 5.3 software according to the Cochrane tool. Nineteen studies on a total of 404 animals were included with five kinds of experimental animal models. The results showed that serum total bilirubin (TBIL), direct bilirubin (DBIL), indirect bilirubin and total bile acid in the group treated with Yinchenhao decoction were significantly lower than those in the model group (P < 0.00001). The alanine aminotransferase (ALT), aspartate aminotransferase and alkaline phosphatase levels in the Yinchenhao decoction group were also significantly reduced (P < 0.00001). The subgroup analysis of the different models showed that Yinchenhao decoction had a significant effect on the bile duct ligation model, and there was a significant reduction in TBIL, DBIL and ALT levels (P < 0.00001) in ANIT‐induced cholestasis. After 24 hours of Yinchenhao decoction treatment, there was no significant difference in TBIL levels (P = 0.34), but after 48 and 72 hours of treatment, the TBIL levels were significantly reduced compared with the model group (P < 0.00001). There was no significant difference in DBIL after 48 hours of administration (P = 0.26), but compared with the model group, Yinchenhao decoction could significantly reduce the DBIL levels after 48 hours of treatment (P < 0.0003). Yinchenhao decoction could significantly reduce the ALT levels after 24, 48 and 72 hours (P < 0.006). Yinchenhao decoction was able to significantly reduce the levels of TBIL, DBIL and ALT on different rat species: Wistar and Sprague Dawley (P = 0.0001; P = 0.0002). The preclinical evidence indicated that Yinchenhao decoction might be a potent and promising agent for cholestasis. Moreover, this conclusion should be further confirmed with more well‐designed researches.

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Section: Introductionmentioning

confidence: 99%

Preclinical evidence of Yinchenhao decoction on cholestasis: A systematic review and meta‐analysisof animal studies

Shi

Wen

Zeng

et al. 2020

Phytotherapy Research

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“…The combination of Astragalus membranaceus and Glycyrrhiza uralensis has shown clinical efficacy to treat liver diseases by the inhibition of notch signaling pathways 65 . It was also reported that this herb pair is able to inhibit bile acid-stimulated inflammation in chronic cholestatic liver injury mice 56 based on transcriptomics profiling 55 . However, their active ingredients and the mechanisms of action of remain poorly understood.…”

Section: Resultsmentioning

confidence: 97%

“…It is reported that the herb pair Huang Qi (the root of Astragalus membranaceus ) and Gan Cao (the root and rhizome of Glycyrrhiza uralensis ) can be used for liver fibrosis and cirrhosis treatment, while neither Astragalus membranaceus nor Glycyrrhiza uralensis shows therapeutic effects when used alone 55, 56 . Therefore, it is important to identify the synergistic interactions of the ingredients underlying the herb pair for treating liver diseases.…”

Section: Methodsmentioning

confidence: 99%

Network-based modeling of herb combinations in Traditional Chinese Medicine

Wang

Yang

Chen

et al. 2021

Preprint

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Traditional Chinese Medicine (TCM) has been practiced for thousands of years for treating human diseases. In comparison to modern medicine, one of the advantages of TCM is the principle of herb compatibility, known as TCM formulae. A TCM formula usually consists of multiple herbs to achieve the maximum treatment effects, where their interactions are believed to elicit the therapeutic effects. Despite being a fundamental component of TCM, the rationale of combining specific herb combinations remains unclear. In this study, we proposed a network-based method to quantify the interactions in herb pairs. We constructed a protein-protein interaction network for a given herb pair by retrieving the associated ingredients and protein targets, and determined multiple network-based distances including the closest, shortest, center, kernel, and separation, both at the ingredient and at the target levels. We found that the frequently used herb pairs tend to have shorter distances compared to random herb pairs, suggesting that a therapeutic herb pair is more likely to affect neighboring proteins in the human interactome. Furthermore, we found that the center distance determined at the ingredient level improves the discrimination of top-frequent herb pairs from random herb pairs, suggesting the rationale of considering the topologically important ingredients for inferring the mechanisms of action of TCM. Taken together, we have provided a network pharmacology framework to quantify the degree of herb interactions, which shall help explore the space of herb combinations more effectively to identify the synergistic compound interactions based on network topology.

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“…is formula is applied to inhibit CVD developments such as atherosclerosis, stroke, deep vein thrombosis, and cerebral infarction. An increasing number of clinical researches emphasize the positive effect of HQ in treating CVD, for example, HQ, has been proven to protect cardiovascular disease through multiple mechanisms, including anti-inflammatory and lipid lowering effects [10][11][12]. Several recent clinical studies showed that HQ can enhance myocardial contractility and myocardial cell excitation-contraction coupling and generate significant cardiotonic effect with the treatment of acute myocardial infarction [13,14].…”

Section: Introductionmentioning

confidence: 99%

Network Pharmacology‐Based Approach to Investigate the Mechanisms of Mahai Capsules in the Treatment of Cardiovascular Diseases

Shi

Yuan

et al. 2020

Evidence-Based Complementary and Alternative Medicine

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Background. Mahai capsules (MHC) have been deemed to be an effective herb combination for treatment of cardiovascular diseases (CVD) development and improvement of the life quality of CVD patients. To systematically explore the mechanisms of MHC in CVD, a network pharmacology approach mainly comprising target prediction, network construction, biological process and pathway analysis, and related diseases was adopted in this study. Methods. We collected the bioactive compounds and potential targets of MHC through the TCMSP servers. Candidate targets related to CVD were collected from Therapeutic Targets Database and PharmGkb database and analyzed using ClueGO plugin in Cytoscape. KEGG pathway was enriched and analyzed through the EnrichR platform, and protein-protein interaction networks were calculated by STRING platform. The compound-target, target-disease, and compound-target-disease networks were constructed using Cytoscape. Results. A total of 303 targets of the 57 active ingredients in MHC were obtained. The network analysis showed that PTGS2, PTGS1, HSP90, Scn1a, estrogen receptor, calmodulin, and thrombin were identified as key targets of MHC in the treatment of CVD. The functional enrichment analysis indicated that MHC probably produced the therapeutic effects against CVD by synergistically regulating many biological pathways, such as PI3K-Akt, TNF, HIF-1, FoxO, apoptosis, calcium, T-cell receptor, VEGF, and NF-kappa B signaling pathway. Conclusions. In summary, the analysis of the complete profile of the pharmacological properties, as well as the elucidation of targets, networks, and pathways, can further illuminate that the underlying mechanisms of MHC in CVD might be strongly associated with its synergic regulation of inflammation, apoptosis, and immune function, and provide new clues for its future development of therapeutic strategies and basic research.

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Protective effect of herbal medicine Huangqi decoction against chronic cholestatic liver injury by inhibiting bile acid-stimulated inflammation in DDC-induced mice

Cited by 47 publications

References 40 publications

Preclinical evidence of Yinchenhao decoction on cholestasis: A systematic review and meta‐analysisof animal studies

Preclinical evidence of Yinchenhao decoction on cholestasis: A systematic review and meta‐analysisof animal studies

Network-based modeling of herb combinations in Traditional Chinese Medicine

Network Pharmacology‐Based Approach to Investigate the Mechanisms of Mahai Capsules in the Treatment of Cardiovascular Diseases

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