Protective effect of hydrogen sulfide against stress-induced lung injury: involvement of Nrf2, NFκB/iNOS, and HIF-1α signaling pathways

Ali, Fatma; Mohammed, Hanaa Hassanein; Ali, Doaa M.

doi:10.1007/s12192-021-01248-8

Cited by 5 publications

(2 citation statements)

References 45 publications

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“…Previous study has confirmed that Sirt1 gene serves as the upstream regulator of Nrf2 signaling pathway, which mediates the antioxidant effect of leptin (Song et al 2018;Zhang et al 2018). Nrf2 plays a crucial role in cellular antioxidant defense mechanisms (Ren et al 2011;Hepp et al 2021;Ali et al 2022). This is in agreement with a previous study, which has reported that leptin attenuated the development of oxidative stress (Bilbao et al 2015) and enhanced the transcription of antioxidants, which neutralized free radicals (Fernandez-Martos et al 2012;Buldak et al 2015;Kornowski et al 2021) as indicated by up-regulation of the gene expression of Nrf2 along with the elevation of level of antioxidants in ovarian tissue in the present study (Alshaheen et al 2021).…”

Section: Discussionsupporting

confidence: 92%

Leptin alleviated ovarian ischemia-reperfusion injury in rats via modulation of Sirt-1/Nrf2 and TLR4/NF-kB/caspase-3 signaling pathways

Abdel-Hamid

Maqsoud

Toni

et al. 2023

Endocrine Regulations

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Objective. Ovarian torsion is a gynecological emergency that occurs mostly during the female reproductive years due to ovarian masses or surgical manipulation. This work aims to explore the probable protective effect of leptin on rat ovaries due to ischemia-reperfusion (IR) injury. Methods. Wistar albino rats were divided into four groups: 1) control group; 2) ovarian IR group (OVIR); 3) leptin group I [OVIR + leptin (10 µg/kg body weight, b.w.)]; and 4) leptin group II (OVIR + leptin (100 µg/kg b.w.)]. Serum levels of estradiol and anti-Mullerian hormone (AMH) were measured. Levels of oxidative stress and inflammatory markers in ovarian tissue were determined along with the expression of sirtuin 1 (Sirt1), nuclear erythroid factor-2 (Nrf2), cyclooxygenase-2 (COX-2), nuclear factor kappa (NF-κB), toll like receptor-4 (TLR4), and caspase-3. Results. Serum estradiol and AMH levels were decreased with increased expression of COX-2, TLR4, caspase-3, and NF-κB and decreased expression of Sirt1and Nrf2 in ovary of the OVIR group, which were improved by exogenous administration of both leptin doses. Conclusion. Leptin administration dose-dependently reduced the severity of OVIR injury via modulation of Sirt-1/Nrf2 and TLR4/NF-kB/caspase-3 signaling pathways. Thus, leptin may be used as an adjuvant measure to prevent ovarian damage and improve the outcomes. However, clinical studies are needed to evaluate these results in humans.

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Section: Discussionsupporting

confidence: 92%

Leptin alleviated ovarian ischemia-reperfusion injury in rats via modulation of Sirt-1/Nrf2 and TLR4/NF-kB/caspase-3 signaling pathways

Abdel-Hamid

Maqsoud

Toni

et al. 2023

Endocrine Regulations

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“…These findings suggest that NaHS may be a novel therapy for COPD. Additionally, NaHS protects against stress-induced lung injury because of its antioxidative, anti-inflammatory, antifibrotic, and antiapoptotic properties (114). Over the past few decades, several H 2 S-based treatment approaches, including those based on H 2 S donation and the restriction of H 2 S generation, have been identified.…”

Section: Sodium Hydrosulfidementioning

confidence: 99%

Hypoxia-inducible factor 1-alpha is a driving mechanism linking chronic obstructive pulmonary disease to lung cancer

Wang

2022

Front. Oncol.

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Patients with chronic obstructive pulmonary disease (COPD), irrespective of their smoking history, are more likely to develop lung cancer than the general population. This is mainly because COPD is characterized by chronic persistent inflammation and hypoxia, which are the risk factors for lung cancer. However, the mechanisms underlying this observation are still unknown. Hypoxia-inducible factor 1-alpha (HIF-1α) plays an important role in the crosstalk that exists between inflammation and hypoxia. Furthermore, HIF-1α is the main regulator of somatic adaptation to hypoxia and is highly expressed in hypoxic environments. In this review, we discuss the molecular aspects of the crosstalk between hypoxia and inflammation, showing that HIF-1α is an important signaling pathway that drives COPD progression to lung cancer. Here, we also provide an overview of HIF-1α and its principal regulatory mechanisms, briefly describe HIF-1α-targeted therapy in lung cancer, and summarize substances that may be used to target HIF-1α at the level of COPD-induced inflammation.

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Ultra-sensitive analysis of exhaled biomarkers in ozone-exposed mice via PAI-TOFMS assisted with machine learning algorithms

Yang,

Li,

Chen

et al. 2024

Journal of Hazardous Materials

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Protective effect of hydrogen sulfide against stress-induced lung injury: involvement of Nrf2, NFκB/iNOS, and HIF-1α signaling pathways

Cited by 5 publications

References 45 publications

Leptin alleviated ovarian ischemia-reperfusion injury in rats via modulation of Sirt-1/Nrf2 and TLR4/NF-kB/caspase-3 signaling pathways

Leptin alleviated ovarian ischemia-reperfusion injury in rats via modulation of Sirt-1/Nrf2 and TLR4/NF-kB/caspase-3 signaling pathways

Hypoxia-inducible factor 1-alpha is a driving mechanism linking chronic obstructive pulmonary disease to lung cancer

Ultra-sensitive analysis of exhaled biomarkers in ozone-exposed mice via PAI-TOFMS assisted with machine learning algorithms

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