Protective effect of hyperbaric oxygen treatment on rat intestinal mucosa after mesenteric ischaemia and reperfusion

Açıksarı, Kurtuluş; Eğin, Seracettin; Hepgül, Gülçin; Mirasoğlu, Bengüsu; Tanrıverdi, Gamze; Kanber, Devrim S; Demirci, Sibel; Doğan, Halil; Özüçelik, Doğaç Niyazi; Toklu, Akın Savaş; Seçkin, İsmail; Yanar, Hakan

doi:10.28920/dhm49.4.253-258

Cited by 5 publications

(4 citation statements)

References 20 publications

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“…However, there are data that contradict our findings. For instance, in [ 27 ], although the level of MDA did not reach a statistically significant level, it was greater in the groups getting HBOT than in the other groups. In this study, the rise in MDA levels was seen as a marker of oxidative damage that was supposed to arise from increased oxygen levels in the cells as a result of HBOT.…”

Section: Discussionmentioning

confidence: 99%

Examining the Effects of Hyperbaric Oxygen Therapy on the Cardiovascular System and Oxidative Stress in Insulin-Treated and Non-Treated Diabetic Rats

Ristic,

Savic,

Bolevich

et al. 2023

Animals

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Background: This study explored the effects of hyperbaric oxygen therapy (HBOT) on the cardiovascular system and oxidative stress in streptozotocin-induced diabetic rats. Wistar albino rats were divided into four groups: DM group (diabetic rats), DM+HBOT group (diabetic rats exposed to HBOT for 1 h daily, five days a week, at 2.8 atmosphere absolute (ATA) with 100% oxygen for two weeks), DM+INS group (diabetic rats treated with neutral protamine hagedorn (NPH) insulin at a dosage of 3–5 U/day), and DM+HBOT+INS group (diabetic rats treated with both NPH insulin and HBOT for two weeks). Methods: Evaluations included glycemic control, oxidative stress parameters, and cardiac function measurements. Results: NPH insulin treatment reduced blood glucose levels, although normoglycemia was not achieved. The DM+HBOT+INS group demonstrated the lowest pro-oxidative marker levels. NPH insulin treatment improved cardiac function, and combination therapy effectively restored cardiac function in diabetic animals. Conclusions: NPH insulin treatment reduced hyperglycemia and improved cardiac function in diabetic rats. The combined approach of NPH insulin and HBOT resulted in decreased pro-oxidative markers. These findings provide valuable insights for managing cardiovascular complications and oxidative stress in diabetes.

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Section: Discussionmentioning

confidence: 99%

Examining the Effects of Hyperbaric Oxygen Therapy on the Cardiovascular System and Oxidative Stress in Insulin-Treated and Non-Treated Diabetic Rats

Ristic,

Savic,

Bolevich

et al. 2023

Animals

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“…The goal of this research was to see if HBOT could help the rats' intestinal mucosa repair. The HBOT therapy resulted in a reduction in pre-and post-ischemia-induced lesion size, as well as enhanced cell viability via caspase-3 reduction, enhanced CD34 stem cells, and elevated VEGF [72].…”

Section: Hbot In the Treatment Of Dfu In Animalsmentioning

confidence: 96%

Insight on Hyperbaric Oxygen Therapy as an Adjunctive Treatmentin Diabetic Foot Ulcer: A Review

Eladl

Allam

Abdelbasset

et al. 2022

JPRI

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Diabetic foot ulcers (DFU) are a source of major concern for both patients and health care systems. DFU is the most expensive and devastating complication of diabetes mellitus, which affect 15% of diabetic patients during their lifetime. That can lead to infection, gangrene, amputation, and even death if necessary care is not provided. On the other hand, once DFU has developed, there is an increased risk of ulcer progression that may ultimately lead to amputation. Overall, the rate of lower limb amputation in patients with diabetes mellitus is 15 times higher than patients without diabetes. Hyperbaric oxygen therapy (HBOT) can be defined as a mode of medical treatment in which the patient is entirely enclosed in a pressure chamber and breathes 100% oxygen at a pressure greater than 1 atmosphere absolute (ATA). HBOT can be used as an adjunct to standard wound care in the treatment of diabetic patients with foot ulcers. HBOT has been demonstrated to have an antimicrobial effect and to increase oxygenation of hypoxic wound tissues. This enhances neutrophil killing ability, stimulates angiogenesis, and enhances fibroblast activity, collagen synthesis and alter vascular activity. Thus, theoretically, HBOT could improve the healing of ischemic foot ulcers in patients with diabetes. This review focuses on providing an up-to-date summary of the currently available evidence-based data on HBOT in DFU, as well as elaborating its use in the management of diabetic injuries both ischemic and non-ischemic ulcers.

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“…The mentioned results have also been verified by Zhou et al (102), but their research further explored the specific mechanism and proposed that HBO given during ischemia can supplement oxygen, resist hypoxic metabolism, maintain ATP levels, and inhibit TNF-α overproduction; on the other hand, HBO increases tissue oxygen reserves during ischemia, which mitochondria can use to maintain ATP levels. Recently, the experimental results in the study by Açiksari et al (103) showed that HBOT has a protective effect on rat mesenteric IR injury, and their experimental results are more accurate, suggesting that the effect is the best 6 h after reperfusion.…”

Section: Hyperbaric Oxygen Therapy For Iirmentioning

confidence: 99%

Effects of Hyperbaric Oxygen Therapy on Intestinal Ischemia-Reperfusion and Its Mechanism

Song,

Li,

et al. 2023

Shock

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Ischemia can cause reversible or irreversible cell or tissue damage, and reperfusion after ischemia not only has no therapeutic effect, but also aggravates cell damage. Notably, gut tissue is highly susceptible to ischemia-reperfusion injury under many adverse health conditions. Intestinal ischemia-reperfusion (IIR) is an important pathophysiological process in critical clinical diseases. Therefore, it is necessary to identify better therapeutic methods for relieving intestinal ischemia and hypoxia. Hyperbaric oxygenation (HBO) refers to the intermittent inhalation of 100% oxygen in an environment greater than 1 atmosphere pressure, which can better increase the oxygen level in the tissue, and change the inflammatory pathway. Currently, it can have a positive effect on hypoxia and ischemic diseases. Related studies have suggested that hyperbaric oxygen can significantly reduce ischemia-hypoxic injury to the brain, spinal cord, kidney and myocardium. This paper reviews the pathogenesis of ischemia-reperfusion and the current treatment measures, and further points out that hyperbaric oxygen has a better effect in ischemia-reperfusion. We found that not only improved hypoxia, but also regulated ischemia-reperfusion-induced injury in a certain way. From the perspective of clinical application, these changes and the application of hyperbaric oxygen therapyhave important implications for treatment, especially intestinal ischemia-reperfusion.

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Protective effect of hyperbaric oxygen treatment on rat intestinal mucosa after mesenteric ischaemia and reperfusion

Cited by 5 publications

References 20 publications

Examining the Effects of Hyperbaric Oxygen Therapy on the Cardiovascular System and Oxidative Stress in Insulin-Treated and Non-Treated Diabetic Rats

Examining the Effects of Hyperbaric Oxygen Therapy on the Cardiovascular System and Oxidative Stress in Insulin-Treated and Non-Treated Diabetic Rats

Insight on Hyperbaric Oxygen Therapy as an Adjunctive Treatmentin Diabetic Foot Ulcer: A Review

Effects of Hyperbaric Oxygen Therapy on Intestinal Ischemia-Reperfusion and Its Mechanism

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