Protective effect of hyperimmune egg yolk IgY antibodies against Eimeria tenella and Eimeria maxima infections

Lee, S.H.; Lillehoj, Hyun S.; Park, D.W.; Jang, Seung I.; Morales, Ana Isabel; García, Daymir; Lucio-Decanini, Eduardo; Larios, R.; Victoria, G.; Lillehoj, Erik P.

doi:10.1016/j.vetpar.2009.04.020

Cited by 78 publications

(54 citation statements)

References 15 publications

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“…Oocyst numbers were determined using a McMaster chamber (HK Inc., Tokyo, Japan) (Yoo et al, 2009). Gut lesion scores were determined at day 20 (day 2 post-infection with C. perfringens) on a scale of 0 (none) to 4 (high) by three independent observers in a blinded fashion as described (Johnson and Reid, 1970;Lee et al, 2009). All protocols were approved by the Beltsville Area Institutional Animal Care and Use Committee.…”

Section: Experimental Ne Disease Modelmentioning

confidence: 99%

Genetically Disparate Fayoumi Chicken Lines Show Different Response to Avian Necrotic Enteritis

et al. 2015

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Necrotic enteritis (NE) has reemerged as a significant problem as a result of growing restrictions of antibiotics in agricultural animal production and increasing concerns over antibiotic resistance in human pathogens. To enhance our understanding of host-pathogen immunobiology in NE, transcriptional analysis was conducted to compare changes in NE-induced intestinal transcripts and to identify immune-related genes whose expression are associated with NE disease resistance using two genetically disparate Fayoumi chicken lines, M5.1 and M15.2. NE was induced by co-infection of Eimeria maxima and Clostridium perfringens using an established disease model and two major NE-induced clinical signs, body weight loss and intestinal lesions, were measured in two inbred Fayoumi chicken lines, M5.1 and M15.2. In the clinical criteria, line M5.1 chickens were more resistant to NE compared to line 15.2 birds. Although they have the same genetic background, these two chicken lines are genetically disparate at their major histocompatibility complex (MHC) and this difference was reflected in the differential expression patterns of several inflammatory genes such as suppressor of cytokine signaling 3 (SOCS3), interleukin 8 (IL8), nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, zeta (NFKBIZ), serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1 (SERPINF1), and gap junction protein, alpha 1, 43kDa (GJA1) between NE-afflicted and uninfected chickens. These results will lead to increased insights on the NE disease resistance mechanisms and the role of host genes controlling host immune response to C. perfringens.

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Section: Experimental Ne Disease Modelmentioning

confidence: 99%

Genetically Disparate Fayoumi Chicken Lines Show Different Response to Avian Necrotic Enteritis

et al. 2015

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“…Oral administration of IgY antibodies has been tested for many years with promising results [80] to different pathogens as human rotavirus [81]; dental plaque formation by Streptococcus mutans [82,83]; enteropathogenic E. coli [84]; Helicobacter pylori [85,86]; Cryptosporidium parvum [87,88]; canine parvovirus [89]; Porphyromonas gingivalis [90]; Pseudomonas aeruginosa [91]; shrimp's white spot syndrome virus [92]; Eimeria acervulina [93]; E. tenella and E. maxima [94,95]; H5N1 e H1N1 in mice [96]; Vibrio cholerae [97]; rotavirus and norovirus [98]; Campylobacter jejuni [99][100][101]; and botulinum neurotoxins [102]. Immunotherapy as a passive immunization method to neutralize venom using purified IgY proved to be efficient for therapy protocol [103][104][105][106][107].…”

Section: Using Igy For Passive Immunizationmentioning

confidence: 99%

IgY-Technology Applied to Studies of Toxoplasma gondii Infection

Júnior¹,

Santos²,

Bassi³

et al. 2017

Toxoplasmosis

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In this chapter, we describe relevant aspects of immunoglobulin Y (IgY) technology for Toxoplasma gondii applications, including comparison of avian IgY antibody with mammalian IgG antibody, egg yolk IgY production and isolation procedures, important applications for IgY antibody, and state of the art and perspectives for IgY-technology in T. gondii studies. T. gondii is a worldwide public health problem. IgY-technology provides an alternative antibody (IgY) to mammalian Immunoglobulin G (IgG) antibody. IgY-technology involves the chicken immunization, yolk IgY isolation, antibody characterization, and purified IgY application to several kinds of methods. Immunized chicken transfers a specific IgY from blood to egg yolk. Phylogenetic distance between chickens and mammals influences the generation of antibody repertoires recognizing an antigen profile. IgY is not bound to rheumatoid factor or mammalian complement protein and thus avoids the false-positive results. Yolk IgY isolation is carried out by simple procedures that are accessible for any laboratory and, also, for IgY isolation at large-scale production. IgY-technology provides antibodies for proteomic studies, diagnostic assays, and immunotherapy. Although IgY-technology is promising, there is a reduced number of investigations with IgY and T. gondii. Future perspectives involve the use of IgY-technology for the screening of new T. gondii antigens for diagnostics, therapy, or vaccine, development of innovative techniques for toxoplasmosis diagnostics and may be an immunotherapy for toxoplasmosis.

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“…Coccidiosis is a managemental disease of poultry and ranks among the most important diseases of poultry worldwide (Lee et al 2009). It has been documented that coccidiosis is the most consistently reported health problem in poultry (Biggs 1982;Williams 1999).…”

Section: Introductionmentioning

confidence: 99%

Anticoccidial activity of aqueous extract of a wild mushroom (Ganoderma applanatum) during experimentally induced coccidial infection in broiler chicken

2014

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Despite presence of anticoccidial drugs and vaccines in the market, coccidiosis continues to result in substantial economic losses to the poultry industry. There is wide-spread resistance to already known anticoccidial drugs. It is an infectious disease of poultry and rigorous management is required during vaccination. In addition there is possibility of drug residues in meat and other byproducts of such treated animals and consequently makes more imperative to explore and understand the role of natural products in livestock parasite management. Therefore a study was designed to evaluate the anticoccidial activity of aqueous extract of Ganoderma applanatum in broiler chicken. In-vivo anticoccidial activity of aqueous extract of G. applanatum was measured in comparison to the reference drug amprolium on the basis of oocysts per gram of faeces, weight gain and feed conversion ratio. Oocyst output was measured with the help of Mc-Masters counting technique. The results of this study established the virulence of coccidian oocysts and the effectiveness of both amprolium and aqueous extract of G. applanatum against coccidian oocysts, confirmed by the fact that treatment with aqueous extract of G. applanatum resulted in a noticeable reduction in coccidian oocysts output, leading to improved weight gain and better feed conversion ratio.The study highlighted the potential of G. applanatum as a natural source of bioactive components for controlling a protozoan parasite, which can be isolated and tested in a bioassay-guided manner and harnessed in the form of anticoccidial drugs.

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Protective effect of hyperimmune egg yolk IgY antibodies against Eimeria tenella and Eimeria maxima infections

Cited by 78 publications

References 15 publications

Genetically Disparate Fayoumi Chicken Lines Show Different Response to Avian Necrotic Enteritis

Genetically Disparate Fayoumi Chicken Lines Show Different Response to Avian Necrotic Enteritis

IgY-Technology Applied to Studies of Toxoplasma gondii Infection

Anticoccidial activity of aqueous extract of a wild mushroom (Ganoderma applanatum) during experimentally induced coccidial infection in broiler chicken

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