Protective Effect of <i>Agave salmiana</i> Fructans in Azoxymethane-Induced Colon Cancer in Wistar Rats

Dávila-Céspedes, A; Bi, Joffe; Jm, Pinos-Rodríguezc; Aguirre-Riverab,; Ac, Oros-Ovalled; Ed, Loyola-Martínez; Andrade-Zaldívar, Hera

doi:10.1177/1934578x1400901025

Cited by 4 publications

(2 citation statements)

References 27 publications

(32 reference statements)

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“…Chicory inulin has been identified as an effective prebiotic to promote active fermentation and lactobacilli proliferation in the large intestine and to enhance calcium digestive absorption and deposition in bones [ 7 ]. The Mexican agave plant is an important source of fructans, which had demonstrated bifidogenic effects in animal models [ 8 ]; however, ITF of Agave genus have been poorly studied for their possible protective effects in others diseases [ 9 ], for example, cancer and osteoporosis. Colon cancer is a problem of public health and shows a high mortality rate and may be related to eating habits.…”

Section: Introductionmentioning

confidence: 99%

Functional Effects of Prebiotic Fructans in Colon Cancer and Calcium Metabolism in Animal Models

Rivera-Huerta

Lizárraga-Grimes

Castro-Torres

et al. 2017

BioMed Research International

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Inulin-type fructans are polymers of fructose molecules and are known for their capacity to enhance absorption of calcium and magnesium, to modulate gut microbiota and energy metabolism, and to improve glycemia. We evaluated and compared the effects of Chicory inulin “Synergy 1®” and inulin from Mexican agave “Metlin®” in two experimental models of colon cancer and bone calcium metabolism in mice and rats. Inulins inhibited the development of dextran sulfate sodium-induced colitis and colon cancer in mice; these fructans reduced the concentration of tumor necrosis factor alpha and prevented the formation of intestinal polyps, villous atrophy, and lymphoid hyperplasia. On the other hand, inulin treatments significantly increased bone densitometry (femur and vertebra) in ovariectomized rats without altering the concentration of many serum biochemical parameters and urinary parameters. Histopathology results were compared between different experimental groups. There were no apparent histological changes in rats treated with inulins and a mixture of inulins-isoflavones. Our results showed that inulin-type fructans have health-promoting properties related to enhanced calcium absorption, potential anticancer properties, and anti-inflammatory effects. The use of inulin as a prebiotic can improve health and prevent development of chronic diseases such as cancer and osteoporosis.

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Section: Introductionmentioning

confidence: 99%

Functional Effects of Prebiotic Fructans in Colon Cancer and Calcium Metabolism in Animal Models

Rivera-Huerta

Lizárraga-Grimes

Castro-Torres

et al. 2017

BioMed Research International

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“…After eight weeks of treatment, the colon cancer preneoplastic stage was induced by administering two intraperitoneal doses of 15 mg of the carcinogenic drug azoxymethane (AOM) (Sigma-Aldrich ® , San Louis Missouri, USA, A2853) by kg of body weight, dissolved in sterile solution saline (0.85 %) (Dávila-Céspedes et al, 2014), one at the end of the eighth week and the other at the end of the ninth week of the experimental period.…”

Section: Inducement Of Incipient Colorectal Carcinogenesismentioning

confidence: 99%

Femur Characteristics and Fecal Nitrogen in Healthy and Cancer-Affected Wistar Rats Supplemented With Inulin and Agave Fructans

Regalado-Rentería,

Juárez-Flores,

García-López

et al. 2023

agro

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The aim of this study was to evaluate the effect of 10 % supplementation with commercial chicory fructans (I), commercial Agave tequilana fructans (ATC), experimental A. tequilana fructans (ATE), experimental A. salmiana fructans (AS), rice starch (RS), and a control diet (C) on Wistar rats, both healthy and carcinogen-induced to colorectal cancer. It was hypothesized that agave and chicory fructans have similar effects. The supplements evaluated in both experiments maintained the dry weight and length of rat femurs in both groups without producing significant changes. Only healthy rats supplemented with chicory and both A. tequilana fructans showed higher fecal nitrogen levels. The femur ash content in rats that were carcinogen-induced to develop colorectal cancer was significantly lower (p ≤ 0.05) than the content in healthy rats. Minerals in the femurs of both groups of rats were similar. The hypothesis of this work was rejected.

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Fast Centrifugal Partition Chromatography Fractionation of Concentrated Agave (Agave salmiana) Sap to Obtain Saponins with Apoptotic Effect on Colon Cancer Cells

Santos-Zea

Fajardo-Ramírez

Romo-López

et al. 2015

Plant Foods Hum Nutr

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Separation of potentially bioactive components from foods and plant extracts is one of the main challenges for their study. Centrifugal partition chromatography has been a successful technique for the screening and identification of molecules with bioactive potential, such as steroidal saponins. Agave is a source of steroidal saponins with anticancer potential, though the activity of these compounds in concentrated agave sap has not been yet explored. In this study, fast centrifugal partition chromatography (FCPC) was used coupled with in vitro tests on HT-29 cells as a screening procedure to identify apoptotic saponins from an acetonic extract of concentrated agave sap. The three most bioactive fractions obtained by FCPC at partition coefficients between 0.23 and 0.4 contained steroidal saponins, predominantly magueyoside b. Flow cytometry analysis determined that the fraction rich in kammogenin and manogenin glycosides induced apoptosis, but when gentrogenin and hecogenin glycosides were also found in the fraction, a necrotic effect was observed. In conclusion, this study provides the evidence that steroidal saponins in concentrated agave sap were potential inductors of apoptosis and that it was possible to separate them using fast centrifugal partition chromatography.

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Protective Effect of Agave salmiana Fructans in Azoxymethane-Induced Colon Cancer in Wistar Rats

Cited by 4 publications

References 27 publications

Functional Effects of Prebiotic Fructans in Colon Cancer and Calcium Metabolism in Animal Models

Functional Effects of Prebiotic Fructans in Colon Cancer and Calcium Metabolism in Animal Models

Femur Characteristics and Fecal Nitrogen in Healthy and Cancer-Affected Wistar Rats Supplemented With Inulin and Agave Fructans

Fast Centrifugal Partition Chromatography Fractionation of Concentrated Agave (Agave salmiana) Sap to Obtain Saponins with Apoptotic Effect on Colon Cancer Cells

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