Protective effect of<i>Amaranthus spinosus</i>against<scp>d</scp>-galactosamine/lipopolysaccharide-induced hepatic failure

Hussain, Zeashan; Gupta, Ashish; Singh, Santosh K.; Rao, Chandana Venkateswara

doi:10.3109/13880200903168023

Cited by 15 publications

(10 citation statements)

References 36 publications

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“…Moreover, extract treatment was also found to significantly increase activities of NP-SH and TP in liver tissue [58]. Results of an another study revealed that 50% ethanolic * All the studies mention: no acute toxicity at 2000 mg/kg BW whole plant extract of A. spinosus could afford a significant protection against d-galactosamine/lipopolysaccharide-induced liver injury in rats [59]. Whole plant methanolic extract of A. spinosus showed significant (p < 0.001) hepatoprotective activity against paracetamol induced hepatotoxicity in Wistar rats [60].…”

Section: Hepatoprotectivementioning

confidence: 99%

Rediscovering the therapeutic potential of Amaranthus species: A review

Peter

Gandhi

2017

Egyptian Journal of Basic and Applied Sciences

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Extracts of Amaranthus have been used to treat several ailments since ancient times. However, Amaranthus spp. has seen a resurgence of interest in recent decades. Literature summarization of in vitro and in vivo studies established that Amaranthus spp. has several protective and curative properties attributed majorly to strong antioxidant activity. This comprehensive review critically analyzes folklore claims of Amaranthus with scientific evidences, delineating its phytochemical based nutrapharmaceutical properties and emphasizes clinical utility of the plant in various chronic diseases, also defining gap areas for future clinical research. Data on 13 edible Amaranthus spp. was acquired via an electronic search including regional scientific journals, theses, books and government reports. These results provide an in-depth analysis of biological effects of major bioactive ingredients present in crude extracts of specific bioparts. However, bioavailability and underlying mechanism of action of constituents isolated from Amaranthus spp. have not been worked out, thus necessitating focused research in this arena.

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Section: Hepatoprotectivementioning

confidence: 99%

Rediscovering the therapeutic potential of Amaranthus species: A review

Peter

Gandhi

2017

Egyptian Journal of Basic and Applied Sciences

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“…dGalN/LPS-induced hepatic damage was manifested by increasing in the activities of enzymes such as ALP, gamma glutamyl transferase, ALT, AST, and lactate dehydrogenase and by decreasing in bilirubin level of serum. Pretreatment (400 mg/kg) of rats with ASE significantly reversed these altered parameters to normal compared to the intoxicated group (25).…”

Section: Effect and Trial Researchesmentioning

confidence: 89%

“…Activity against CCL 4 may be due to the presence compounds such as of flavonoids and phenolics in the ASE which may have hepatoprotective activities (2). Hence, it is possible that the hepatoprotective mechanism of whole plant A. spinosus is due to its antioxidant activity (25).…”

Section: Mechanism Of Actionmentioning

confidence: 99%

A review for discovering hepatoprotective herbal drugs with least side effects on kidney

Shirani¹,

Raeisi²,

Heidari-Soureshjani³

et al. 2017

J Nephropharmacol

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“…In diabetic patients, hyperglycemia is associated with dyslipidemia due to the uninhibited actions of lipolytic hormones on the fat depots, mainly due to the action of insulin [32] . The dyslipidemia is characterized by increase in SC, ST, LDL, VLDL, and fall in HDL [47] , [48] .…”

Section: Discussionmentioning

confidence: 99%

Pharmacodynamic evaluation of self micro-emulsifying formulation of standardized extract of Lagerstroemia speciosa for antidiabetic activity

Agarwal

Gupta

Chandra

2018

Journal of Ayurveda and Integrative Medicine

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BackgroundLagerstroemia speciosa (SEL) leaves are a popular folk medicine for diabetes treatment due to presence of corosolic acid. It has low water solubility resulting poor absorption after oral administration. Self micro-emulsified drug delivery system is the way by which we can improve the oral absorption of drug.ObjectiveThe objective of this study was to develop the self micro-emulsifying formulation of standardized extract of SEL leaves and evaluate its pharmacodynamic performance for antidiabetic activity.Materials and methodsThe SME formulation was prepared by using sefsol-218 as oil, cremophor-EL as surfactant and transcutol-P as co-surfactant. The ratio of surfactant and co-surfactant was determined by pseudoternary phase diagram. SME formulations were characterized for dilution at different pH, self emulsification, optical clarity, globule size and thermodynamic stability. Pharmacodynamic evaluation of formulations was assessed in Wistar rats by using parameters viz. blood glucose level and serum lipid profile.ResultsSEL loaded SME formulation was successfully developed by using sefsol-218, cremophor-EL and transcutol-P with a droplet size 23.53 nm. Pharmacodynamic results showed a higher reduction in blood glucose by SME formulation than SEL without SMES respectively at 50 mg/kg dose while reduction produced at dose of 100 mg/kg was found significant and better on 15th day of study. The percentage reduction produced by SME formulation on serum lipid profile was also significant and was more prominent than SEL.ConclusionThis study confirms that the formulation elevates the pharmacodynamic performance of SEL approximately two fold.

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Protective effect ofAmaranthus spinosusagainstd-galactosamine/lipopolysaccharide-induced hepatic failure

Cited by 15 publications

References 36 publications

Rediscovering the therapeutic potential of Amaranthus species: A review

Rediscovering the therapeutic potential of Amaranthus species: A review

A review for discovering hepatoprotective herbal drugs with least side effects on kidney

Pharmacodynamic evaluation of self micro-emulsifying formulation of standardized extract of Lagerstroemia speciosa for antidiabetic activity

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