Protective effect of<i>Dunaliella</i>sp., lipid extract rich in polyunsaturated fatty acids, on hepatic and renal toxicity induced by nickel in rats

Moussa, Ines Dahmen‐Ben; Bellassoued, Khaled; Athmouni, Khaled; Naifar, Manel; Chtourou, Haifa; Ayadi, Habib; Makni‐Ayadi, Fatma; Sayadi, Sami; Feki, Abdelfettah El; Dhouib, Abdelhafidh

doi:10.3109/15376516.2016.1158340

Cited by 14 publications

(12 citation statements)

References 37 publications

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“…Through the absence of enough GPx activity or GSH levels, LOP and hydrogen peroxide are not detoxified and perhaps converted by transition metals to hydroxyl radicals and lipid peroxyl radicals. The findings were similar to the results of Kubrak et al [36] and Dahmen-Ben Moussa et al [21] who found decreased GPx, CAT and SOD activities in the rat kidney by Ni cytotoxicty of antioxidant capacity may be coupled with the depletion of GSH and reduced total sulfhydryl contents or with their increased utilization for quenching free radicals and/or their inactivation by excessive Ni oxidation. Furthermore, Ni was reported to trigger nitric oxide (NO) creation [43], which may inhibit both CAT activities by binding to its heme prosthetic group [44] and GPx activity [45].…”

Section: Bouhalit and Kechridsupporting

confidence: 81%

“…Our results were in accordance with those reported by Amudha and Pari [2], who mentioned a significant increase in the relative kidney weight in Nitreated male rats. However, our results were opposing those reported by Dahmen-Ben Moussa et al [21] and Adeyemi and Elebiy [20] who exhibited that Ni treatment resulted in a significant decrease in relative kidney weight. In the present work, coadministration of methionine prevented changes in relative kidney weight and body weights.…”

Section: Bouhalit and Kechridcontrasting

confidence: 57%

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Assessment of the Potential Role of L- Methionine on Nickel Sulfate Induced Renal Injury and Oxidative Stress in Rat

Bouhalit

Kechrid

2018

Asian J Pharm Clin Res

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Objective: The study was designed to investigate the possible protective role of methionine (Met) in nickel sulfate induced oxidative stress in renal tissue.Methods: Rats were divided into the following groups: Healthy control; L-methionine (Met, 100 mg/kg, orally); nickel sulfate (Ni, 20 mg/kg, intraperitoneally); and combination Ni+Met. The experiment lasted 21 days. Antioxidant and renal function parameters with histological study were performed. Results:In the Ni group, marked renal damage was noticed with the significant elevation in the levels of creatinine, urea, and uric acid in serum. Animals also showed a significant rise in the lipid peroxidation level with a concomitant decrease in glutathione (GSH) and various antioxidant enzymes GSH peroxidase, catalase, and superoxide dismutase. Moreover, these changes in rats given the combined therapy nickel plus methionine were significantly less than those of group nickel, met prevented these alterations and maintained the antioxidant status. Histopathological examination of the kidney tissue proved the protective effect of Met against nickel toxicity. Conclusions:These results demonstrated that methionine augments antioxidant defense against nickel-induced toxicity and provides evidence that it has therapeutic potential as a renoprotective agent.

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Section: Bouhalit and Kechridsupporting

confidence: 81%

Section: Bouhalit and Kechridcontrasting

confidence: 57%

Assessment of the Potential Role of L- Methionine on Nickel Sulfate Induced Renal Injury and Oxidative Stress in Rat

Bouhalit

Kechrid

2018

Asian J Pharm Clin Res

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“…Nickel is a silvery-white transition metal that takes on a high polish. The toxicity of nickel depends on the way of its exposure and the solubility of the compound like other metals [41].…”

Section: Removal Of Metal Ions With Imprinted Materialsmentioning

confidence: 99%

Molecularly Imprinted Polymers for Removal of Metal Ions: An Alternative Treatment Method

et al. 2018

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Aquatic and terrestrial environment and human health have been seriously threatened with the release of metal-containing wastewater by the rapid growth in the industry. There are various methods which have been used for removal of ions from the environment, such as membrane filtration, ion exchange, membrane assisted liquid extraction and adsorption. As a sort of special innovation, a polymerization technique, namely molecular imprinting is carried out by specific identification for the target by mixing it with a functional monomer. After the polymerization occurred, the target ion can be removed with suitable methods. At the end of this process, specific cavities, namely binding sites, are able to recognize target ions selectively. However, the selectivity of the molecularly imprinted polymer is variable not only because of the type of ligand but also charge, size coordination number, and geometry of the target ion. In this review, metal ion-imprinted polymeric materials that can be applied for metal ion removal from different sources are discussed and exemplified briefly with different metal ions.

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“…Dunaliella sp. CTM 20028 have been isolated for the first time from Chott El-Djerid (Southern Tunisia) with a mean salinity of 142 PSU [17]. Chott El-Djerid (5.…”

Section: Methods Of Cultivation and Antioxidant Assays 21 Isolation mentioning

confidence: 99%

Antioxidant Properties of Metabolites from New Extremophiles Microalgal Strain (Southern, Tunisia)

Gammoudi¹,

Moussa²,

Annabi-Trabelsi³

et al. 2021

Antioxidants - Benefits, Sources, Mechanisms of Action

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With the demand for bioproducts that can provide benefits for biotechnology sectors like pharmaceuticals, nutraceuticals, and cosmeceuticals, the exploration of microalgal products has turned toward extremophiles. This chapter is intended to provide an insight to most important molecules from halotolerant species, the cyanobacteria Phormidium versicolor NCC-466 and Dunaliella sp. CTM20028 isolated from Sfax Solar Saltern (Sfax) and Chott El-Djerid (Tozeur), Tunisia. These microalgae have been cultured in standard medium with a salinity of 80 PSU. The in vitro antioxidant activities demonstrated that extremolyte from Dunaliella and Phormidium as, phycocaynin, lipids, and polyphenol compound presents an important antioxidant potential.

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Protective effect ofDunaliellasp., lipid extract rich in polyunsaturated fatty acids, on hepatic and renal toxicity induced by nickel in rats

Abstract: LE of Dunaliella sp., rich in PUFA has been proven to be effective in protection against Ni-induced toxicity.

Cited by 14 publications

References 37 publications

Assessment of the Potential Role of L- Methionine on Nickel Sulfate Induced Renal Injury and Oxidative Stress in Rat

Assessment of the Potential Role of L- Methionine on Nickel Sulfate Induced Renal Injury and Oxidative Stress in Rat

Molecularly Imprinted Polymers for Removal of Metal Ions: An Alternative Treatment Method

Antioxidant Properties of Metabolites from New Extremophiles Microalgal Strain (Southern, Tunisia)

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