Protective Effect of <i>Ginkgo biloba</i> and Magnetized Water on Nephropathy in Induced Type 2 Diabetes in Rat

Zayed, Ahmed E.; Saleh, Ahmed M.; Gomaa, Asmaa M.S.; Abd-Elkareem, Mahmoud; Anwar, Mamdouh M.; Hassanein, Khaled; Elsherbiny, Mohsen M.; Kotb, Ahmed M.

doi:10.1155/2018/1785614

Cited by 17 publications

(24 citation statements)

References 54 publications

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“…Ginkgolides A, B and C. Decrease the level of ROS, the release of LDH, TNF-α, IL-1β and IL-6 and the expression of c-fos and c-jun mRNA; inhibits activation factor of platelets and of signaling pathway NIK/IKK α/IkB/NF-κB; increases cellular proliferation, activity of free radicals capture, activation of the p42/p44 (ERK) MAPK pathways, levels of mRNA and the protein from the HIF-1α. [38], the administration of EGB761 in mice with inducted DM2 resulted in the reduction of glycemia in a very significant way and reduced the levels of urea and creatinine in comparison to diabetic mice that were not treated. The work of Rhee et al [39] induced type 1 diabetes mellitus (DM1) and DM2 in mice and showed that the use of EGB761 reduced glycemia and levels of insulin.…”

Section: Compound Action Referencesmentioning

confidence: 89%

Effects of Ginkgo biloba on Diseases Related to Oxidative Stress

et al. 2020

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ABSTR AC TGinkgo biloba (GB) is one of the most widely used phytotherapeutic products in the world, and its extract has beneficial properties for the treatment of several pathologies, such as diabetic cardiomyopathy, neurodegenerative diseases, cataracts, hearing loss, myocardial lesion, hippocampus neuronal lesions, morphometry testicular changes, and liver damage. This review aims to investigate the effects of GB on diseases related to oxidative stress. Databases such as MEDLINE/ PUBMED and EMBASE were consulted, and PRISMA guidelines were used to build the review. This plant has antioxidant properties since it regulates the expression of antioxidant enzymes positively and reduces reactive oxygen and nitrogen species, contributing to the reduction of lipid peroxidation. It also exhibits anti-inflammatory properties, inhibiting the expression of pro-inflammatory cytokines, such as IL-1, IL-6, and TNF-α. In animal models, the use of GB can show positive effects on brain damage, neurodegenerative diseases, myocardial injury, and renal and liver damage. In humans, the positive effects were shown in diabetes, metabolic syndrome, and ischemic colitis. These effects are due to the presence of compounds such as bilobalide, isoramnetina, quercetin, kaempferol, and ginkgolides A, B, and C. For these reasons, GB can be a lowcost alternative to the therapeutic approach of several pathologies since it acts in the prevention, treatment, and inhibition of several complications of common comorbidities.

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Section: Compound Action Referencesmentioning

confidence: 89%

Effects of Ginkgo biloba on Diseases Related to Oxidative Stress

et al. 2020

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“…Magnetic water has been shown to alter the pH of water to neutral or alkaline, which can mitigate the effects of oxidative stress. For example, Zayed et al (2018) found that providing MW to type 2 diabetic rats can reduce oxidative stress, hyperlipidemia, uremia, and renal dysfunction. In human, Weidman et al (2016) reported a relation between oxidative stress and blood viscosity.…”

Section: Resultsmentioning

confidence: 99%

“…In the biomedical field, provision of MW to rats for 30 days increased mineral density and mineral content of their bone compared to those of rats receiving non-magnetic water (Balieiro-Neto et al, 2017). In addition, providing MW to diabetic rats protected their kidneys from nephrotoxic damages as one of type 2 diabetes related complications (Zayed et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

Physicochemical Properties of Magnetic Water and Its Effect on Egg Production Traits in Hens at Late Laying Period

2020

THE JAPS

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This study was conducted to evaluate the egg production traits of laying hens receiving magnetic water (MW) for one month. Sixty Fayoumi hens at 54 weeks of age were used. On d 1 of the trial, hens were randomly assigned to control (non-magnetic water) and treatment (magnetic water, MW) groups. During the experiment, pH and electrical conductivity (EC) of water were recorded. The water nano-structure was investigated by electron microscopy. In parallel, egg mass, egg number, egg weight, egg production, and feed intake were recorded daily. Results showed that both pH and EC values of MW were higher compared to those of non-magnetic water (P ≤ 0.05). In MW, notable changes in the order and size of water molecules at the edge of water clusters were observed. Providing MW for the first two weeks did not affect any of productive traits. From third week of the experiment, egg production of MW group (34.5 ± 1.8 %) was significantly higher than this (27.8 ± 2.1 %) of control ones. In conclusion, physiochemical properties of MW may indirectly maintain hens' productivity in late age. Nevertheless, interdisciplinary investigations should be carried out to elucidate the mode of action of MW and probable side effects if any.

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“…Previously, it was shown that EGb761 alleviated renal damage in a rat model of diabetic nephropathy [Zayed et al, 2018]. In this report, we investigated whether EGb761 exerted its protective effect on statin-induced myopathy via antagonizing the oxidative stress.…”

Section: Egb761 Reversed Sim-induced Changes In Gastrocnemius Muscle mentioning

confidence: 92%

Alleviation of Simvastatin-Induced Myopathy in Rats by the Standardized Extract of Ginkgo Biloba (EGb761): Insights into the Mechanisms of Action

Mahmoud

Kamel

Ahmed

et al. 2019

Cells Tissues Organs

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Statins are the most widely prescribed cholesterol-lowering drugs to reduce the risk of cardiovascular diseases. Statininduced myopathy is the major side effect of this class of drugs. Here, we studied whether standardized leaf extracts of ginkgo biloba (EGb761) would improve simvastatin (SIM)induced muscle changes. Sixty Wistar rats were allotted into six groups: control group, vehicle group receiving 0.5% carboxymethyl cellulose (CMC) for 30 days, SIM group receiving 80 mg/kg/day SIM in 0.5% CMC orally for 30 days, SIM withdrawal group treated with SIM for 16 days and sacrificed 14 days later, and EGb761-100 and EGb761-200 groups posttreated with either 100 or 200 mg/kg/day EGb761 orally. Muscle performance on the rotarod, serum creatine kinase (CK), coenzyme Q 10 (CoQ 10 ), serum and muscle nitrite, muscle malondialdehyde (MDA), superoxide dismutase (SOD), and catalase (CAT) activities were estimated. Additionally, muscle samples were processed for histopathological evalu-ation. We found that SIM decreased muscle performance on the rotarod, serum CoQ 10 , as well as muscle SOD and CAT activities while it increased serum CK, serum and muscle nitrite, as well as muscle MDA levels. SIM also induced sarcoplasmic vacuolation, splitting of myofibers, disorganization of sarcomeres, and disintegration of myofilaments. In contrast, posttreatment with EGb761 increased muscle performance, serum CoQ 10 , as well as muscle SOD and CAT activities while it reduced serum CK as well as serum and muscle nitrite levels in a dose-dependent manner. Additionally, EGb761 reversed SIM-induced histopathological changes with better results obtained by its higher dose. Interestingly, SIM withdrawal increased muscle performance on the rotarod, reduce serum CK and CoQ 10 , and reduced serum and muscle nitrite while it reversed SIM-induced histopathological changes. However, SIM withdrawal was not effective enough to restore their normal values. Additionally, SIM withdrawal did not improve SIM-induce muscle MDA, SOD, or CAT activities during the period studied. Our results suggest that EGb761 posttreatment reversed SIM-induces muscle changes possibly through its antioxidant effects, elevation of CoQ 10 levels, and antagonizing mitochondrial damage.

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Protective Effect of Ginkgo biloba and Magnetized Water on Nephropathy in Induced Type 2 Diabetes in Rat

Cited by 17 publications

References 54 publications

Effects of Ginkgo biloba on Diseases Related to Oxidative Stress

Effects of Ginkgo biloba on Diseases Related to Oxidative Stress

Physicochemical Properties of Magnetic Water and Its Effect on Egg Production Traits in Hens at Late Laying Period

Alleviation of Simvastatin-Induced Myopathy in Rats by the Standardized Extract of Ginkgo Biloba (EGb761): Insights into the Mechanisms of Action

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