Protective effect of inactivated blastoconidia in keratinocytes and human reconstituted epithelium against<i>C. albicans</i>infection

Alburquenque, Claudio; Amaro, José Peña; Fuentes, Marisol; Falconer, Mary A; Moreno, Cláudia; Covarrubias, Cristian; Pinto, Cristian; Rodas, Paula I.; Bucarey, Sergio A.; Hermosilla, Gabriel; Magne, Fabien; Tapia, Cecilia

doi:10.1093/mmy/myy068

Cited by 2 publications

(2 citation statements)

References 41 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In such trained monocytes, a metabolic switch was demonstrated to aerobic glycolysis, which was crucial for maintenance of trained immunity, as seen in the Warburg effect in the neoplastic cells [60]. Short pre-stimulation of RHOE with heat-killed C. albicans yeast showed a significant increase in the expression of human β-defensins 2 and 3 associated with impaired growth and viability of the fungus [61]. Further clarification of these phenomena is expected.…”

Section: Immunity Against Candidamentioning

confidence: 94%

Candida-Associated Gastric Ulcer Revisited

Sasaki¹

2021

jbacteriolmycol

View full text Add to dashboard Cite

Candida-associated gastric ulcer occurs not only in debilitated but healthy individuals. Though had been reported to demonstrate nothing but nonspecific endoscopic features, it occasionally exhibits a typical finding I designated a candidarium. The natural history of the disease had not been clarified and the recurrence had not been described. However, I demonstrated that the ulcer not only occurs but also recurs in a different site with a different shape in a non-diabetic, H. pylori-negative patient, who has not taken NSAIDs, antibiotics, antineoplastic agents, or systemic corticosteroids, advocating that, contrary to the prevailing opinion, Candida is no innocuous bystander but an etiologic perpetrator. It has recently been shown to secrete a cytolytic PFT, candidalysin, into a pocket in the epithelium after penetrating into it to activate MAPK/MKP1/ c-Fos pathway, triggering release of damage as well as immune cytokines in OPC and VVC. While candidalysin, exerting an effect even on the adjacent oropharyngeal cells, directly injures the tissue with damage cytokines, immune counterparts activate PMNs to eventually terminate inflammation. Though the epithelial response to the fungus is different from organ to organ, it invades into and induces necrotic cellular damage to the IECs through the toxin to translocate: the action of candidalysin is proven not only on the squamous but on the columnar epithelium. Since, by analogy with intestinal candidiasis, it is never difficult to speculate that the PFT inflicts such damage to the gastric mucosa, a theoretically strong possibility has come up that Candida-associated gastric ulcer is actually Candida-induced.

show abstract

Section: Immunity Against Candidamentioning

confidence: 94%

Candida-Associated Gastric Ulcer Revisited

Sasaki¹

2021

jbacteriolmycol

View full text Add to dashboard Cite

show abstract

“…As above mentioned, human oral and vaginal epithelial cells have grown mechanisms to detect fungal burden and discriminate between commensal and pathogenic states of C. albicans (Moyes et al, 2010(Moyes et al, , 2011Tang et al, 2016), suggesting that long-term responses may regulate host-C. albicans interactions both in health and disease. More recently, Alburquenque et al showed that short pre-stimulation of reconstituted human epithelium with C. albicans heat-killed yeast cells increased human βdefensin 3 expression, and reduced fungal viability and adherence (Alburquenque et al, 2019).…”

Section: Role Of Innate Immune Memory In Mucosal Surfaces Defensementioning

confidence: 99%