Protective Effect of Isoliquiritigenin against Ethanol-Induced Hepatic Steatosis by Regulating the SIRT1-AMPK Pathway

Na, Ann-Yae; Yang, Eun‐Ju; Jeon, Ju Mi; Ki, Sung Hwan; Song, Kyung‐Sik; Lee, Sangkyu

doi:10.5487/tr.2018.34.1.023

Cited by 37 publications

(19 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Liquiritigenin inhibits LXR-dependent steatosis and oxidative damage [40]. Isoliquiritigenin has been reported to protect against alcohol-induced fatty liver by regulating the SIRT-1-AMPK pathway and to inhibit LXRα-dependent steatosis [41] [42]. In the present study, levels of isoliquiritigenin were higher in F4408 than in F4404 as compared with SM (Table 3).…”

Section: Flavanones In F4404 and F4408supporting

confidence: 48%

Metabolite Profile of Lactic Acid-Fermented Soymilk

Kobayashi¹,

Shima²,

Fukuda³

2018

FNS

View full text Add to dashboard Cite

Isoflavone aglycone-rich soymilk fermented by Lactobacillus delbrueckii subsp. delbrueckii, strain TUA-4408L (F4408) has stronger lipid metabolism-modulating effects than isoflavone aglycone-poor soymilk fermented by Lactobacillus delbrueckii subsp. delbrueckii, strain TUA-4404L (F4404). As such, fermentation products other than isoflavone aglycones may also exert lipid metabolism-modulating effects. Therefore, the present study aimed to compare the metabolites in soymilk (SM), F4404, and F4408 via a metabolomics approach. Various aglycones including isoflavones, flavones, flavonols, and flavanones increased in both F4404 and F4408 compared with SM. The increases in isoflavone and flavanone aglycones were greater in F4408 than in F4404. Some types of dipeptides and free amino acids, especially ornithine, increased in both fermented soymilks. The increase in free amino acids, especially ornithine, was higher in F4408 than in F4404. Thus, F4408 exhibited stronger glycosidase and protease activities than F4404. Functional components produced by lactic acid fermentation are known to improve lipid metabolism. Therefore, it is suggested that not only isoflavone aglycones but also other functional components exert lipid metabolism-modulating effects in fermented soymilks, especially soymilk fermented using TUA-4408L.

show abstract

Section: Flavanones In F4404 and F4408supporting

confidence: 48%

Metabolite Profile of Lactic Acid-Fermented Soymilk

Kobayashi¹,

Shima²,

Fukuda³

2018

FNS

View full text Add to dashboard Cite

show abstract

“…Several AMACR inhibitors have been developed, such as 2-methylacyl-CoA analogs containing fluorine on the β-carbon 2 or in the methyl group 1, including 2-(trifluoromethyl)-tetradecanoyl-CoA, (3R, 2S)-3-fluoro-2-methylhexadecanoyl-CoA, E-13-iodo-2-methylenetridec-12-enoyl-CoA, ebselen, ebselen oxide, and 2-(2,5-dihydroxy-4-methylphenyl)-5-methylbenzene-1,4-diol ( 5 ). AMACR has also been studied as a target for peptide vaccines.…”

Section: Discussionmentioning

confidence: 99%

“…AMACR is a peroxisomal and mitochondrial enzyme that plays a key role in the metabolism of cholesterol and branched-chain fatty acids. The function of AMACR in cancer is associated with lipid metabolism and the activity of nuclear receptors such as farnesoid X receptor and peroxisome proliferation activation receptor and expression of cyclooxygenase-2 ( 5 ). In this study, we investigated the potential of AMACR as a biomarker in brain tumors.…”

Section: Introductionmentioning

confidence: 99%

Alpha-Methylacyl-CoA Racemase (AMACR), a Potential New Biomarker for Glioblastoma

Lee

Kim

et al. 2020

Front. Oncol.

View full text Add to dashboard Cite

Alpha-Methylacyl-CoA racemase (AMACR), which was initially discovered as a prostate cancer marker, is critical for the chiral inversion mechanism of branched-chain fatty acids. However, the function of AMACR in brain tumors has not been investigated. In this study, AMACR appeared to be involved in glioblastoma. The protein and mRNA levels of AMACR were highly elevated in glioblastoma. Downregulation of AMACR inhibited cell proliferation. Comprehensive analysis of the public REMBRANDT GBM dataset also confirmed that the level of AMACR expression was correlated with the clinical prognosis of glioma patients. In summary, these findings indicate that AMACR expression is increased in a glioblastoma cell line and glioma patients, suggesting that AMACR might be a potential diagnostic marker and therapeutic target for cancer, including glioma.

show abstract

“…CS is an important inducer of oxidative stress and the inflammatory response, which leads to the pathogenesis of COPD ( van der Vaart et al, 2004 ; Churg et al, 2008 ; Cheng et al, 2015 ). ILG, extracted from the root of liquorice, has been widely used to cure many inflammatory diseases, because of its anticancer, antioxidant, and anti-inflammatory properties ( Zeng et al, 2017 ; Chen et al, 2018 ; Li et al, 2018 ; Na et al, 2018 ). In the present study, we tested the mechanism and protective effects of ILG on CS-induced COPD.…”

Section: Discussionmentioning

confidence: 99%

Isoliquiritigenin Inhibits Cigarette Smoke-Induced COPD by Attenuating Inflammation and Oxidative Stress via the Regulation of the Nrf2 and NF-κB Signaling Pathways

Liu

Zhang

et al. 2018

Front. Pharmacol.

View full text Add to dashboard Cite

Chronic obstructive pulmonary disease (COPD) is the major leading cause of disease with high-mortality worldwide. Cigarette smoke (CS) is a major factor for COPD. CS causes chronic inflammation and oxidative stress, which contributes to lung dysfunction in COPD. Isoliquiritigenin (ILG), a natural flavonoid derived from the root of liquorice, has been reported to possess antiinflammatory and antioxidant activity. In the present study, we tested the mechanism and protective effects of ILG on CS-induced COPD. Mice were exposed to CS for 2 h twice a day for 4 weeks. ILG was given orally 1 h before CS exposure twice a day for 4 weeks. The bronchial alveolar lavage fluid was collected to test the levels of inflammatory cytokines and the number of inflammatory cells. The lung tissues were obtained to evaluate the pathological changes, lung edema, myeloperoxidase (MPO) activity, malondialdehyde (MDA) level, as well as the expression of the nuclear factor-erythroid 2 (Nrf2) and nuclear factor κB (NF-κB) signaling pathways. The results showed that ILG reduced the infiltration of inflammatory cells and the production of inflammatory cytokines. ILG also reversed CS-induced lung pathological injuries, wet/dry ratio, MPO activity, and MDA level. Further research also showed that ILG dose-dependently up-regulated the expression of Nrf2 and down-regulated the expression of NF-κB signaling pathways induced by CS. In conclusion, ILG protected against CS-induced COPD by inhibiting inflammatory and oxidative stress via the regulation of the Nrf2 and NF-κB signaling pathways.

show abstract

Protective Effect of Isoliquiritigenin against Ethanol-Induced Hepatic Steatosis by Regulating the SIRT1-AMPK Pathway

Cited by 37 publications

References 35 publications

Metabolite Profile of Lactic Acid-Fermented Soymilk

Metabolite Profile of Lactic Acid-Fermented Soymilk

Alpha-Methylacyl-CoA Racemase (AMACR), a Potential New Biomarker for Glioblastoma

Isoliquiritigenin Inhibits Cigarette Smoke-Induced COPD by Attenuating Inflammation and Oxidative Stress via the Regulation of the Nrf2 and NF-κB Signaling Pathways

Contact Info

Product

Resources

About